Cat. No.: HY-Y0337A

L-Cysteine hydrochloride

12 Cited Publications

Customer Review

Based on 12 publication(s) in Google Scholar

L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF).

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 52-89-1
Formula: C₃H₈ClNO₂S
Molecular Weight:157.62

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

L-Cysteine hydrochloride Chemical Structure

CAS No.: 52-89-1

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (12)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

L-Cysteine hydrochloride (1 and 3 mM) significantly reduced acetylcholine (0.01-10 μM) induced relaxations in rat aortic rings^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-Cysteine hydrochloride (oral gavage or i.p., 4 mmol/kg or 2 mmol/kg, a single dose for 1 h) decreases food intake in rodents, suppresses plasma ghrelin and increases neuronal activation in the rat brainstem^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats and mice fasted overnight^[1]
Dosage:

oral gavage administration of 4 mmol/kg, i.p. administration of 2 mmol/kg
Administration:

orally gavage or i.p., a single dose for 1 h
Result:

Dose-dependently decreased food intake in rats and mice and significantly reduced cFLI in the lateral hypothalamic area (LHA) in rats.

Chemical Information

CAS No. 52-89-1
Appearance Solid
Molecular Weight 157.62
Formula C₃H₈ClNO₂S
Color White to off-white
SMILES

N[C@@H](CS)C(O)=O.Cl
Structure Classification
- Amino acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (12)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Metab

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology. [Abstract]

2025 Jan 7;37(1):291-304.e9. PMID: 39413790
J Nanobiotechnology

Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration. [Abstract]

2026 Feb 28;24(1):315. PMID: 41761314
Adv Sci (Weinh)

Targeting the SOX9/TIMP1 Axis with iRGD-Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer. [Abstract]

2025 Nov 21:e10500. PMID: 41270217
Int J Biol Sci

MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis. [Abstract]

2023 Aug 21;19(14):4457-4475. PMID: 37781038
Life Metab

2025 Oct 8.
Probiotics Antimicrob Proteins

Potential Benefits of Metformin Via Roseburia Intestinalis in High-fat Diet-fed Mice With Colorectal Adenomas. [Abstract]

2025 Nov 26. PMID: 41296177
J Chromatogr A

Preparation of thiol-free amino acid plasma matrix for quantification of thiol amino acids and their oxidized forms in human plasma by UPLC-MS/MS. [Abstract]

2024 Apr 12:1720:464776. PMID: 38432109
Amino Acids

Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]

2024 Sep 18;56(1):56. PMID: 39292313
Sci Total Environ

Network pharmacology and transcriptomics reveal androgen receptor as a potential protein target for 6PPD-quinone. [Abstract]

2024 Dec 20:957:177678. PMID: 39581451
Research Square Preprint

2024 Jan 24.
SSRN

2023 Nov 17.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (634.44 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3444 mL

31.7219 mL

63.4437 mL

5 mM

1.2689 mL

6.3444 mL

12.6887 mL

10 mM

0.6344 mL

3.1722 mL

6.3444 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 25 mg/mL (158.61 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55. [Content Brief]

[2]. Qiu M, et al. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB1 synthesis by disrupting cell structure and antioxidant system balance. J Hazard Mater. 2023 Oct 5;459:132218. [Content Brief]

[3]. Ellis A, et al. Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta. Br J Pharmacol. 2000 Jan;129(2):315-22. [Content Brief]

[4]. Li T, et al. L-Cysteine hydrochloride delays senescence of harvested longan fruit in relation to modification of redox status[J].

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.3444 mL	31.7219 mL	63.4437 mL	158.6093 mL
	5 mM	1.2689 mL	6.3444 mL	12.6887 mL	31.7219 mL
	10 mM	0.6344 mL	3.1722 mL	6.3444 mL	15.8609 mL
	15 mM	0.4230 mL	2.1148 mL	4.2296 mL	10.5740 mL
	20 mM	0.3172 mL	1.5861 mL	3.1722 mL	7.9305 mL
	25 mM	0.2538 mL	1.2689 mL	2.5377 mL	6.3444 mL
	30 mM	0.2115 mL	1.0574 mL	2.1148 mL	5.2870 mL
	40 mM	0.1586 mL	0.7930 mL	1.5861 mL	3.9652 mL
	50 mM	0.1269 mL	0.6344 mL	1.2689 mL	3.1722 mL
	60 mM	0.1057 mL	0.5287 mL	1.0574 mL	2.6435 mL
	80 mM	0.0793 mL	0.3965 mL	0.7930 mL	1.9826 mL
	100 mM	0.0634 mL	0.3172 mL	0.6344 mL	1.5861 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

L-Cysteine hydrochloride

12 Cited Publications

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L-Cysteine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) L-Cysteine hydrochloride

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (12)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

L-Cysteine hydrochloride Related Classifications

HY-Y0337A Related Classifications