2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Endogenous Metabolite
  4. L-Cysteine

L-システイン  (Synonyms: L-Cysteine; Cysteine)

製品番号: HY-Y0337 純度: 97.0%
COA 取扱説明書 Technical Support

L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent.

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L-Cysteine

L-システイン 構造式

CAS 番号 : 52-90-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
500 mg $25 在庫あり
1 g $30 在庫あり
5 g $50 在庫あり
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50 g   お問い合わせ  

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カスタマーレビュー

Based on 12 publication(s) in Google Scholar

Other Forms of L-Cysteine:

L-システイン 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

L-Cysteine (Cysteine) is an orally active conditionally essential amino acid with hypoglycemic effects, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans. L-Cysteine can be used as an anorectic agent[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

ERK1

 

ERK2

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
161 μM
Compound: 5862
Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells (PubChem AID: 1794812)
Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells (PubChem AID: 1794812)
10.5281/zenodo.7361326
HEK293 EC50
376 μM
Compound: 5862
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)
10.5281/zenodo.6782621
HeLa IC50
> 50 μM
Compound: 3a
Cytotoxic activity against HeLa cells
Cytotoxic activity against HeLa cells
[PMID: 17524640]
SNB-19 IC50
116 μM
Compound: L-cystine
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting
Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation counting
[PMID: 19932968]
体外実験

L-Cysteine (0.1-50 μM, 24 and 48 h) increases cell viability of neural stem cells (NSCs) and promotes proliferation and neuronal differentiation of NSCs[2].
L-cysteine (1 μM, 0-90 min) activates ERK1/2 via CBS/H2S pathway in NSCs[2].
L-Cysteine (0.1-20 mM, 30 min) results in a decrease in glucose uptake in soleus muscle[3].
L-Cysteine (0.5 mM, 30 min) increases GLUT3 levels in SH-SY5Y cells and GLUT4 levels in SH-SY5Y cells, soleus muscle and C2C12 muscle cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-システイン 関連抗体

Cell Viability Assay[2]

Cell Line: NSCs
Concentration: 0.1-50 μM
Incubation Time: 24 and 48 h
Result: Obviously improved the cell viability of NSCs in a dose-dependent manner at lower doses (0.5, 1, 5 μM) and increased the ratio of BrdU-positive cells against total NSCs at 24 h.

Cell Viability Assay[2]

Cell Line: NSCs
Concentration: 1 μM
Incubation Time: 0-90 min
Result: Induced overexpression of phosphorylated ERK (p-ERK1/2) in NSCs.
体内実験

L-Cysteine (1-4 mmol/kg, p.o. or i.p., a single dose for 1 h) decreases food intake in rodents, increases respiratory exchange ratio (RER) in mice, increases neuronal activation in the rat brainstem, reduces gastric emptying and suppresses plasma acyl ghrelin levels in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats following an overnight 16-h fast[1]
Dosage: 1-4 mmol/kg
Administration: p.o. or i.p., a single dose for 1 h
Result: Dose-dependently decreased food intake in rats and mice and significantly increased cFLI in the area postrema in rats.
分子量

121.16

分子式

C3H7NO2S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS)C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 5 mg/mL (41.27 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.2535 mL 41.2677 mL 82.5355 mL
5 mM 1.6507 mL 8.2535 mL 16.5071 mL
10 mM 0.8254 mL 4.1268 mL 8.2535 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (825.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: ≥97.0%

COA (245 KB) HNMR (208 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.2535 mL 41.2677 mL 82.5355 mL 206.3387 mL
5 mM 1.6507 mL 8.2535 mL 16.5071 mL 41.2677 mL
10 mM 0.8254 mL 4.1268 mL 8.2535 mL 20.6339 mL
15 mM 0.5502 mL 2.7512 mL 5.5024 mL 13.7559 mL
20 mM 0.4127 mL 2.0634 mL 4.1268 mL 10.3169 mL
25 mM 0.3301 mL 1.6507 mL 3.3014 mL 8.2535 mL
30 mM 0.2751 mL 1.3756 mL 2.7512 mL 6.8780 mL
40 mM 0.2063 mL 1.0317 mL 2.0634 mL 5.1585 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Cysteine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cysteine52-90-4CysteineEnvironmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsconditionallyhydrogensulphideH2SglutathionetaurineghrelinappetiteInhibitorinhibitorinhibit

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