2. Autophagy Neuronal Signaling PI3K/Akt/mTOR Apoptosis Metabolic Enzyme/Protease
  3. PINK1/Parkin mTOR Apoptosis Prolyl Endopeptidase (PREP)
  4. Salidroside

サリドロシド  (Synonyms: Salidroside; Rhodioloside)

製品番号: HY-N0109 純度: 99.88%
COA 取扱説明書 Technical Support

Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 10338-51-9

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
5 mg $60 在庫あり
10 mg $96 在庫あり
25 mg $170 在庫あり
50 mg $248 在庫あり
100 mg $370 在庫あり
500 mg $880 在庫あり
1 g   お問い合わせ  
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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 44 publication(s) in Google Scholar

Other Forms of Salidroside:

サリドロシド 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Imaging/Staining
Histological Imaging/Staining
IF
WB

    Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72.  [Abstract]

    Live-cell imaging analysis tracking the growth of blood vessels of Tek-CreERT2;mTmG follicles from 12-month-old females with Sal (Salidroside, 50 μM), Ft1, Dosk or vehicle.

    Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72.  [Abstract]

    Tip cells on growing follicles after 7 days of Sal (Salidroside, 300 mg/kg BW, once a day) or vehicle treatment (left), quantifying the number of tip cells (right) showing a significant increase in tip cells on growing follicles after 7 days of Sal treatment (n = 5).

    Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72.  [Abstract]

    Intensity of Evans blue (arrowheads) in ovaries (left) of 12-month-old females after Sal (Salidroside, 300 mg/kg BW, once a day) or vehicle treatment. Quantification of the EB signal (right) indicating Sal treatment significantly increased the blood supply to the ovaries (n = 4).

    Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72.  [Abstract]

    Ovarian morphology with or without Sal treatment (Salidroside, 300 mg/kg BW, once a day) at 12 months, exhibiting an increase in the number of growing follicles (arrows) in the Sal group compared to the control (n = 5 mice).

    Salidroside purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):72.  [Abstract]

    Immunostaining detection of proliferating granulosa cells (red: BrdU, blue: Hoechst) in Sal (Salidroside, 300 mg/kg BW, once a day) and vehicle-treated ovaries at 12 months post-PMSG treatment. Statistical analysis revealing a significantly increase in GC proliferating ratio after Sal treatment compared to the control (n = 5).

    Salidroside purchased from MedChemExpress. Usage Cited in: Int J Oncol. 2019 Jun;54(6):1969-1980.  [Abstract]

    Apoptosis‑related protein expression in MG63 cells in response to various concentrations of Salidroside is detected via western blot analysis.

    mTOR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    mTOR mTORC1 mTORC2

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.

    IC50 & Target[2]

    mTOR

     

    Cellular Effect
    Cell Line Type Value Description References
    HeLa IC50
    10.493 3
    Compound: Sal
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 34978808]
    HeLa IC50
    10.493 3
    Compound: Sal
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 34978808]
    MDA-MB-231 IC50
    40 3
    Compound: 2
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    		[PMID: 33650861]
    MDA-MB-231 IC50
    40 3
    Compound: 2
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    		[PMID: 33650861]
    PC-12 EC50
    0.3 3
    Compound: Cpd i
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    		[PMID: 33097301]
    PC-12 EC50
    0.3 3
    Compound: Cpd i
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    		[PMID: 33097301]
    PC-12 EC50
    0.21 3
    Compound: Salidroside
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells
    		[PMID: 31924497]
    PC-12 EC50
    0.21 3
    Compound: Salidroside
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability
    		[PMID: 32738992]
    HeLa IC50
    10.493 3
    Compound: Sal
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK-8 assay
    		[PMID: 34978808]
    MDA-MB-231 IC50
    40 3
    Compound: 2
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
    		[PMID: 33650861]
    PC-12 EC50
    0.21 3
    Compound: Salidroside
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC12 cells
    		[PMID: 31924497]
    PC-12 EC50
    0.21 3
    Compound: Salidroside
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability
    Neuroprotective activity against CoCl2-induced neuronal injury in rat PC-12 cells assessed as increase in cell viability
    		[PMID: 32738992]
    PC-12 EC50
    0.3 3
    Compound: Cpd i
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    Neuroprotective activity against CoCl2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability pretreated with CoCl2 for 8 hrs followed by incubation with drug and measured after 24 hrs by MTT assay
    		[PMID: 33097301]
    体外実験

    Salidroside (100 μM) inhibits prolyl endopeptidase (PEP) activity (10.6±1.9%). Prolyl endopeptidase is an enzyme that plays a role in the metabolism of proline-containing neuropeptidase which is recognized to be involved in learning and memory[1].
    Salidroside, one of the major phenylpropanoid glycosides found in R.?rosea L, is consumed almost daily as a nutritional supplement in many countries and has been identified possessing potential anti-fatigue and anoxia,anti-aging, and anti-Alzheimer's disease activities. Salidroside can improve muscle nutrition via increasing mTOR, p-mTOR, and MyHC expression[2].
    SH-SY5Y cells are exposed to 0-600?μM MPP+ for 12-48?h and the results show that MPP+ results in a significant decrease of cell viability in a concentration and time-dependent manner. Cells are pretreated with 25-100?μM Salidroside (Sal) for 24?h and then exposed to 500?μM MPP+ for an additional 24?h. Salidroside concentration-dependently prevents MPP+-induced decrease of cell viability. Annexin V/PI staining is a common method for the detection of apoptotic cell. Salidroside significantly decreases the number of Annexin V/PI-stained cells treated by MPP+ which is in a concentration-dependent manner. Apoptotic cell could also be morphologically evaluated by Hoechst staining. In Hoechst staining, apoptotic cells are characterized by reduced nuclear size, chromatin condensation, intense fluorescence, and nuclear fragmentation. Salidroside notably inhibits MPP+-induced increase of chromatin condensation, intense fluorescence, and nuclear fragmentation in SH-SY5Y cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    サリドロシド 関連抗体
    体内実験

    Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. Salidroside (100 mg/kg/day) shows strong glucose lowering effect on db/db mice which is similar to effect of Metformin (200 mg/kg/day)[4].
    Salidroside can be used to induce testicular injury model in mice[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    300.30

    分子式

    C14H20O7
    CAS 番号
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCCC2=CC=C(O)C=C2
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    H2O : 125 mg/mL (416.25 mM; Need ultrasonic)

    DMSO : 100 mg/mL (333.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3300 mL 16.6500 mL 33.3000 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL
    10 mM 0.3330 mL 1.6650 mL 3.3300 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 5 mg/mL (16.65 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (333.00 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.88%

    COA (246 KB) HNMR (274 KB) RP-HPLC (209 KB) MS (230 KB)

    取扱説明書 (2659 KB)
    参考文献
    細胞実験
    [3]

    SH-SY5Y cells are seeded in 96-well plates at 1×104 cells per well. After the treatment with Salidroside (25-100?μM) and MPP+, cell viability is measured by MTT assay. Briefly, cells are incubated with 500?μg/mL MTT at 37°C for 4?h. After that, the medium is removed and 150?μL DMSO is added and shaking is conducted for 10?min. Absorbance is measured at 570?nm in a microplate reader and the results are expressed as folds of control[3].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    動物実験
    [4]

    Mice[4]
    The 4-week-old male C57BL/6 mice are fed a high-fat diet (HFD) (n=16) or normal chow diet (n=8). After 10 weeks of the HFD, salidroside intervention (100 mg/kg/day) is initiated by gavage once a day for 5 weeks. The control groups are given vehicle (saline). The 4-week-old male C57Bl/KsJ (BKS) mice (wild type, n=8) and BKS.Cg-Dock7m +/+ Leprdb/J (db/db) mice (n=16) are used. Salidroside (100 mg/kg/day) is administrated orally by gavage once a day for 5 weeks. The control groups are given vehicle (saline). Fasting blood glucose and body weight of mice are monitored every 5 days. Glucose measurements are performed on blood drawn from the tail vein using a Glucometer.

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.3300 mL 16.6500 mL 33.3000 mL 83.2501 mL
    5 mM 0.6660 mL 3.3300 mL 6.6600 mL 16.6500 mL
    10 mM 0.3330 mL 1.6650 mL 3.3300 mL 8.3250 mL
    15 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
    20 mM 0.1665 mL 0.8325 mL 1.6650 mL 4.1625 mL
    25 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
    30 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
    40 mM 0.0833 mL 0.4163 mL 0.8325 mL 2.0813 mL
    50 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
    60 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
    80 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0406 mL
    100 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8325 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Salidroside Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Salidroside10338-51-9RhodiolosidePINK1/ParkinmTORApoptosisProlyl Endopeptidase (PREP)PTEN-induced kinase 1/ParkinMammalian target of Rapamycinprolyl oligopeptidasePOPInhibitorinhibitorinhibit

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