2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Cirtociclib

Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells.

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CAS. Nr. : 2888704-84-3

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Based on 2 publication(s) in Google Scholar

Cirtociclib Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay

    Cirtociclib purchased from MedChemExpress. Usage Cited in: bioRxiv. 2026 Mar 18.

    Cell viability after 4 days of treatment with Cirtociclib (BLU-222, 0.5-1 μM) and Tagtociclib at the indicated concentrations (average of three biological replicates each with three technical replicates).

    Alle CDK Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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    Beschreibung

    Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells[1][2][3].

    In Vitro

    Cirtociclib (BLU-222) (25-250 nM; 0-288 h) exhibits antiproliferative activity against KLE and HEC-1-B cell lines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cirtociclib Related Antibodies
    In Vivo

    Cirtociclib (BLU-222) (60 mg/kg; twice daily) shows significant anti-tumor activity in both endometrial cancer PDX models[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Klinische Studie
    Molekulargewicht

    365.34

    Formel

    C15H17F2N7O2
    CAS. Nr.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    FC(OC1=CC(NC2=NC3=C(C=NN3CC4CCOCC4)N=C2)=NN1)F
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 100 mg/mL (273.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7372 mL 13.6859 mL 27.3718 mL
    5 mM 0.5474 mL 2.7372 mL 5.4744 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molaritätsrechner

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
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    Calculation results:
    Working solution concentration: mg/mL
    Reinheit & Dokumentation

    Purity: 99.02%

    SDS (251 KB)

    COA (247 KB) HNMR (136 KB) RP-HPLC (231 KB) LCMS (203 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7372 mL 13.6859 mL 27.3718 mL 68.4294 mL
    5 mM 0.5474 mL 2.7372 mL 5.4744 mL 13.6859 mL
    10 mM 0.2737 mL 1.3686 mL 2.7372 mL 6.8429 mL
    15 mM 0.1825 mL 0.9124 mL 1.8248 mL 4.5620 mL
    20 mM 0.1369 mL 0.6843 mL 1.3686 mL 3.4215 mL
    25 mM 0.1095 mL 0.5474 mL 1.0949 mL 2.7372 mL
    30 mM 0.0912 mL 0.4562 mL 0.9124 mL 2.2810 mL
    40 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL
    50 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3686 mL
    60 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1405 mL
    80 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8554 mL
    100 mM 0.0274 mL 0.1369 mL 0.2737 mL 0.6843 mL
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    Cirtociclib Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cirtociclib2888704-84-3BLU-222BLU222BLU 222CDKApoptosisCyclin dependent kinaseCDK2AntitumorInhibitorinhibitorinhibit

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