Carboxymethyl chitosan  (Synonyms: カルボキシメチルキトサン)

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma^{[1][2][3][4][5][6][7][8]}.

Carboxymethyl chitosan (100 μg/mL; 4 days) promotes the proliferation of normal skin fibroblasts but inhibits the proliferation of keloid fibroblasts^[1].
Carboxymethyl chitosan hydrogels show enhanced cell migration compared with standard chitosan hydrogels^[2].
Carboxymethylated chitosan (50-200 μg/mL; 8 h) increases the viability of Schwann cells exposed to H₂O₂ and decreases LDH release in a concentration-dependent manner^[3].
Carboxymethyl chitosan (0.5-2.0 mg/mL; 24-48 h) significantly inhibits the migration of human umbilical vein endothelial cells (HUVECs)^[4].
Carboxymethyl chitosan (50-200 μg/mL; 1 h) inhibits IL-1β-induced apoptosis of rabbit chondrocytes in a dose-dependent manner^[5].
Carboxymethyl chitosan (4.0-5.0 mg/mL; 48 h) decreases viability of OS-RC-2, NCI-H1650, and HT-29 cells^[6].
Carboxymethyl chitosan (1.0-5.0 mg/mL; 12-24 h) can significantly inhibit the two-dimensional migration of BEL-7402 cells in a dose-dependent manner^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carboxymethyl chitosan (75-300 mg/kg; i.p.; administered on days 1, 3, 5, 7, 9, 11, 13) represses tumor angiogenesis in a mouse hepatocarcinoma H22-bearing tumor model^[4].
Carboxymethyl chitosan (20-120 mg/kg; i.v.; every other day; for seven times) can significantly inhibit the growth of Lewis tumor tissue, increase the spleen index of tumor-bearing mice, and make the liver and lung cells arrange more orderly, indicating its effectiveness in repressing Lewis tumor growth and metastasis^[6].
Carboxymethyl chitosan (1350 mg/kg; i.p.) has no significant effects on the coagulation, anticoagulation, fibrinolysis, or hemorheology parameters of rats^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

83512-85-0

Solid

White to light yellow

[Carboxymethyl chitosan]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Chen XG, et al. The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials. 2002 Dec;23(23):4609-14.  [Content Brief]

  [2]. Kruczkowska W, et al. Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels. Molecules. 2024 Sep 13;29(18):4360.  [Content Brief]

  [3]. He B, et al. Carboxymethylated chitosan protects Schwann cells against hydrogen peroxide-induced apoptosis by inhibiting oxidative stress and mitochondria dependent pathway. Eur J Pharmacol. 2018 Apr 15;825:48-56.  [Content Brief]

  [4]. Jiang Z, et al. Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo. Carbohydr Polym. 2015 Sep 20;129:1-8.  [Content Brief]

  [5]. Chen Q, et al. Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1beta-induced apoptosis. Eur J Pharmacol. 2006 Jul 10;541(1-2):1-8.  [Content Brief]

  [6]. Jiang Z, et al. Evaluation on biological compatibility of carboxymethyl chitosan as biomaterials for antitumor drug delivery. J Biomater Appl. 2017 Feb;31(7):985-994.  [Content Brief]

  [7]. Jiang Z, et al. Preparation and anti-tumor metastasis of carboxymethyl chitosan. Carbohydr Polym. 2015 Jul 10;125:53-60.  [Content Brief]

  [8]. Yang Z, et al. Acute toxicity of high dosage carboxymethyl chitosan and its effect on the blood parameters in rats. J Mater Sci Mater Med. 2012 Feb;23(2):457-62.  [Content Brief]