CDK4/6-IN-12 

CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC₅₀ of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer^[1].

CDK4/6-IN-12 (compound 4a) inhibits CDK4 and CDK6 with IC₅₀ of 592.3 nM and 3090 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

238.25

C₁₂H₁₀N₆

2445205-24-1

Solid

Light yellow to green yellow

CC1=CN2C3=NC(N)=NC=C3C(C)=C(C2=N1)C#N

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.  [Content Brief]