2. Others Anti-infection Metabolic Enzyme/Protease
  3. Environmental Pollutants Bacterial Endogenous Metabolite
  4. D-Sorbitol

D(-)-ソルビトール  (Synonyms: Sorbitol; D-Sorbitol; D-Glucitol)

製品番号: HY-B0400 純度: 99.95%
COA 取扱説明書 Technical Support

D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 50-70-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $35 在庫あり
1 g $40 在庫あり
5 g $56 在庫あり
10 g $65 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of D-Sorbitol:

D(-)-ソルビトール 関連抗体

Top Publications Citing Use of Products

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100  mM; 7 d) treatment led to a significantly impaired intestinal organoid from C57BL/6 mice.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 7 d) largely inhibited genes involved in M-cell differentiation (ANXA5, Spi-B, SOX8, and Marcksl1) and the mature M cell marker GP2 in intestinal organoids from C57BL6 mice.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 24 h) largely decreased RANKL in intestinal organoid at the protein level in the M-cell model.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 24 h) decreased M cells mature marker GP2 expression and RANKL expression.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100  mM; 7 d) impaired intestinal organoid in a dose-dependent manner from C57BL/6 mice.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外実験

    Chemically, D-Sorbitol (Sorbitol) can be produced from glucose or sucrose, by hydrogenation at high temperature. D-Sorbitol (Sorbitol) can also be produced by bacteria such as Zymomonas mobilis and Candida boidini, by an enzymatic process[1].
    D-Sorbitol (Sorbitol) is used as a fast disintegrant in capsules and plasticizer in capsule shells and tablet film coatings. In oral liquids, D-Sorbitol (Sorbitol) is used as a sugar substitute and as a drug stabilizer. D-Sorbitol (Sorbitol) is also used as a solubility enhancer for drugs such as indomethacin. D-Sorbitol (Sorbitol) is commonly used as a stabilizing excipient and/or isotonicity agent in both liquid and lyophilized parenteral protein formulations. D-Sorbitol (Sorbitol) is used in topical formulations as a humectant[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    D(-)-ソルビトール 関連抗体
    臨床実験
    分子量

    182.17

    分子式

    C6H14O6
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
    Structure Classification
    Initial Source

    Bacillus subtilis
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at room temperature 3 years

    *In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (548.94 mM; Need ultrasonic)

    DMSO : 100 mg/mL (548.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 110 mg/mL (603.83 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.95%

    COA (246 KB) HNMR (231 KB) RP-HPLC (212 KB) MS (79 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 5.4894 mL 27.4469 mL 54.8938 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 13.7234 mL
    15 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
    20 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8617 mL
    25 mM 0.2196 mL 1.0979 mL 2.1958 mL 5.4894 mL
    30 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
    40 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4309 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.7447 mL
    60 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
    80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-Sorbitol Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-Sorbitol50-70-4Sorbitol D-GlucitolEnvironmental PollutantsBacterialEndogenous MetaboliteEnvironmental ContaminantsSix-carbonsugaralcoholisotonicitysweetenerhumectantthickenerInhibitorinhibitorinhibit

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    製品番号:
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