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  3. Environmental Pollutants Bacterial Endogenous Metabolite
  4. D-Sorbitol

D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement.

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CAS No. : 50-70-4

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
100 mg En stock
500 mg En stock
1 g En stock
5 g En stock
10 g En stock
50 g   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Based on 2 publication(s) in Google Scholar

Other Forms of D-Sorbitol:

D-Sorbitol Related Antibodies

Top Publications Citing Use of Products
Cell Imaging/Staining
RT-PCR
Bio/Physico-chemical Assay
IF

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100  mM; 7 d) treatment led to a significantly impaired intestinal organoid from C57BL/6 mice.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 7 d) largely inhibited genes involved in M-cell differentiation (ANXA5, Spi-B, SOX8, and Marcksl1) and the mature M cell marker GP2 in intestinal organoids from C57BL6 mice.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 24 h) largely decreased RANKL in intestinal organoid at the protein level in the M-cell model.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100 mM; 24 h) decreased M cells mature marker GP2 expression and RANKL expression.

    D-Sorbitol purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2024 May 2:2024:7524314.  [Abstract]

    D-Sorbitol (Sorbitol) (100  mM; 7 d) impaired intestinal organoid in a dose-dependent manner from C57BL/6 mice.

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    Description

    D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement[1].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Chemically, D-Sorbitol (Sorbitol) can be produced from glucose or sucrose, by hydrogenation at high temperature. D-Sorbitol (Sorbitol) can also be produced by bacteria such as Zymomonas mobilis and Candida boidini, by an enzymatic process[1].
    D-Sorbitol (Sorbitol) is used as a fast disintegrant in capsules and plasticizer in capsule shells and tablet film coatings. In oral liquids, D-Sorbitol (Sorbitol) is used as a sugar substitute and as a drug stabilizer. D-Sorbitol (Sorbitol) is also used as a solubility enhancer for drugs such as indomethacin. D-Sorbitol (Sorbitol) is commonly used as a stabilizing excipient and/or isotonicity agent in both liquid and lyophilized parenteral protein formulations. D-Sorbitol (Sorbitol) is used in topical formulations as a humectant[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    D-Sorbitol Related Antibodies
    Essai clinique
    Masse moléculaire

    182.17

    Formule

    C6H14O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
    Structure Classification
    Initial Source

    Bacillus subtilis
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvant et solubilité
    In Vitro: 

    H2O : 100 mg/mL (548.94 mM; Need ultrasonic)

    DMSO : 100 mg/mL (548.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (13.72 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 110 mg/mL (603.83 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (246 KB) HNMR (231 KB) RP-HPLC (212 KB) MS (79 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 5.4894 mL 27.4469 mL 54.8938 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 13.7234 mL
    15 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
    20 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8617 mL
    25 mM 0.2196 mL 1.0979 mL 2.1958 mL 5.4894 mL
    30 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
    40 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4309 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.7447 mL
    60 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
    80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-Sorbitol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-Sorbitol50-70-4Sorbitol D-GlucitolEnvironmental PollutantsBacterialEndogenous MetaboliteEnvironmental ContaminantsSix-carbonsugaralcoholisotonicitysweetenerhumectantthickenerInhibitorinhibitorinhibit

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