2. Others Metabolic Enzyme/Protease Anti-infection
  3. Fungal Environmental Pollutants Succinate Dehydrogenase Antibiotic Cytochrome P450
  4. Fluxapyroxad

Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.

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Fluxapyroxad

Fluxapyroxad 構造式

CAS 番号 : 907204-31-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $80 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of Fluxapyroxad:

Fluxapyroxad 関連抗体

Top Publications Citing Use of Products

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Cytochrome P450 アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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製品説明

Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species[1].

体外実験

Fluxapyroxad (0.1-100 μM, 48 h) inhibits the cell viability of HT-29, downregulates the expression of AHR, CYP1A1, and CYP1A2 genes in cell HT-29, leads to damage of the intestinal barrier and a decrease in the anti-inflammatory cytokine IL-22[2].
Fluxapyroxad (0.03-3 μM, 3 days) decreases the expression of erythrocyte marker genes hbbe1, hbbe2, and gata1a, disrupts the erythropoiesis in zebrafish embryos[3].
Fluxapyroxad inhibits succinate cytochrome c reductase with IC50 of 2.1, 0.71, 11.7 and 0.095 μM in Homo sapiens, Lumbricus terrestrix, Apis mellifera and Botrytis cinerea, respectively[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluxapyroxad 関連抗体

Cell Viability Assay[2]

Cell Line: HT-29
Concentration: 0.1-100 μM
Incubation Time: 48 h
Result: Inhibited the cell viability in a dose-dependent manner.
体内実験

Fluxapyroxad (10 mg/kg/day, po via diet for 13 weeks) induces the body weight gain reduction, colon length reduction, intestinal barrier integrity impairment and proinflammatory cytokines secretion, inducing chronic colonic inflammation in C57BL/6 J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mouse model[2].
Dosage: 10 mg/kg/day
Administration: po via diet for 13 weeks
Result: Decreased body weight gain, shortened the colon length, damaged the colonic crypts, increased the levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α, decreased the level of IL-22, impaired the intestinal barrier integrity.
分子量

381.30

分子式

C18H12F5N3O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2C3=CC(F)=C(F)C(F)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (262.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6226 mL 13.1130 mL 26.2261 mL
5 mM 0.5245 mL 2.6226 mL 5.2452 mL
10 mM 0.2623 mL 1.3113 mL 2.6226 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (13.11 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.96%

COA (251 KB) HNMR (258 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6226 mL 13.1130 mL 26.2261 mL 65.5652 mL
5 mM 0.5245 mL 2.6226 mL 5.2452 mL 13.1130 mL
10 mM 0.2623 mL 1.3113 mL 2.6226 mL 6.5565 mL
15 mM 0.1748 mL 0.8742 mL 1.7484 mL 4.3710 mL
20 mM 0.1311 mL 0.6557 mL 1.3113 mL 3.2783 mL
25 mM 0.1049 mL 0.5245 mL 1.0490 mL 2.6226 mL
30 mM 0.0874 mL 0.4371 mL 0.8742 mL 2.1855 mL
40 mM 0.0656 mL 0.3278 mL 0.6557 mL 1.6391 mL
50 mM 0.0525 mL 0.2623 mL 0.5245 mL 1.3113 mL
60 mM 0.0437 mL 0.2186 mL 0.4371 mL 1.0928 mL
80 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8196 mL
100 mM 0.0262 mL 0.1311 mL 0.2623 mL 0.6557 mL
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Fluxapyroxad Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluxapyroxad907204-31-3FungalEnvironmental PollutantsSuccinate DehydrogenaseAntibioticCytochrome P450Environmental ContaminantsCYPsC57BL/6 J mouseHT-29zebrafishInhibitorinhibitorinhibit

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