2. Gene
  3. Dpp4 - dipeptidylpeptidase 4 Gene

Dpp4 - dipeptidylpeptidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CD26; DPPIV

Gene ID: 25253 | Gene type: protein coding

About Dpp4

Primary_assembly 3: 46,962,243-47,043,901 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 209 orthologues, 6 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 1492.6), Liver (RPKM 372.) and 3 other tissues.

Summary

Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 Products(1)

mRNA Protein Name
NM_012789.2 NP_036921.2 dipeptidyl peptidase 4

Dpp4 Protein Structure

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (105 - 478)

Peptidase_S9

Peptidase_S9: pfam00326 (559 - 763)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 4

DPP IV

GP110 glycoprotein

T-cell activation antigen CD26

bile canaliculus domain-specific membrane glycoprotein

dipeptidyl peptidase IV

Related Agents

Approval
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13749 Sitagliptin Inhibitor 99.76% Yes
HY-10284 Linagliptin 99.91% Unkown
HY-10285 Saxagliptin Inhibitor 99.96% Yes
HY-13749A Sitagliptin phosphate Inhibitor 99.85% Yes
HY-15981 Omarigliptin Inhibitor / Unkown
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.49% Yes
HY-14806 Teneligliptin Inhibitor 99.85% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.99% Unkown
HY-A0023A Alogliptin Inhibitor 99.92% Unkown
HY-14877 Anagliptin Inhibitor 99.91% Unkown
HY-15408 Trelagliptin Inhibitor 99.54% Unkown
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.87% Unkown
HY-14806A Teneligliptin hydrobromide Inhibitor 99.99% Unkown
HY-15408A Trelagliptin succinate Inhibitor 99.96% Unkown
HY-16448 Saxagliptin hydrochloride Inhibitor 99.71% Yes
HY-14892 Gemigliptin Inhibitor / Unkown
HY-108795A Albiglutide fragment TFA Agonist 99.12% Unkown
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
HY-108795 Albiglutide fragment Agonist / Unkown
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-117985B Evogliptin tartrate 99.71% Phase 4
HY-14806S Teneligliptin-d8 / Phase 4
HY-117985 Evogliptin / Phase 4
HY-112668 Retagliptin phosphate Inhibitor 99.89% Phase 3
HY-10286 Dutogliptin Inhibitor 99.32% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.07% Phase 3
HY-10286A Dutogliptin tartrate Inhibitor / Phase 3
HY-12528 DBPR108 Inhibitor 98.75% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99466 Begelomab Inhibitor ≥95.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 98.17% Unkown
HY-P2543 Neuropeptide Y (3-36) (human, rat) Agonist 96.95% Unkown
HY-112668A Retagliptin Inhibitor 98.30% Unkown
HY-147401 Sitagliptin fenilalanil Inhibitor 99.76% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-10284S Linagliptin-d4 99.62% Unkown
HY-124958 NDMC101 Inhibitor 99.59% Unkown
HY-A0023AS Alogliptin-13C,d3 Inhibitor / Unkown
HY-123377 Fotagliptin Inhibitor / Unkown
HY-123377A Fotagliptin benzoate Inhibitor 99.19% Unkown
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% Unkown
HY-10284S1 Linagliptin-13C,d3 / Unkown
HY-13749S1 Sitagliptin-d4 hydrochloride / Unkown
HY-146455 DPP-4-IN-3 Inhibitor / Unkown
HY-146468 DPP-4/GPR119 modulator 1 / Unkown
HY-146469 DPP-4/GPR119 modulator 2 / Unkown
HY-14806S1 Teneligliptin-d4 Inhibitor / Unkown
HY-151383 DPP-4-IN-1 Inhibitor / Unkown
HY-151384 DPP-4-IN-2 Inhibitor / Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-155961 Antidiabetic agent 2 Inhibitor / Unkown
HY-157390 DPP-4-IN-9 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS03963 DPP4 Human Pre-designed siRNA Set A / Unkown
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A / Unkown
HY-13749AS Sitagliptin-d4 phosphate Inhibitor / Unkown
HY-13749D (Rac)-Sitagliptin Inhibitor / Unkown
HY-16656 BMS-767778 Inhibitor / Unkown
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor / Unkown
HY-13749C (S)-Sitagliptin phosphate / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9805 Anti-MERS-3A1 mAb Inhibitor / Unkown
HY-P9806 Anti-MERS-D12 mAb Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp4 NCBI NCBI:1803
Macaca fascicularis Dpp4 NCBI NCBI:102133935
Mus musculus Dpp4 NCBI NCBI:13482