Dpp4 - dipeptidylpeptidase 4 Gene

Also Known as CD26; DPPIV

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25253

About Dpp4

Primary_assembly 3: 46,962,243-47,043,901 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 209 orthologues, 6 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 1492.6), Liver (RPKM 372.) and 3 other tissues.

Summary

Enables several functions, including Collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 Products (1)

mRNA Protein Name
NM_012789.2 NP_036921.2 dipeptidyl peptidase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
8526932 RGD
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
10931192 RGD
enables dipeptidyl-peptidase activity IMP
IMP: Inferred from mutant phenotype
9210490 RGD
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
9210490 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10931192 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
17415460 RGD
Biological Process GO Annotation Evidence References Source
involved in B-1a B cell differentiation IMP
IMP: Inferred from mutant phenotype
19327106 RGD
involved in positive regulation of natural killer cell mediated immunity IMP
IMP: Inferred from mutant phenotype
19327106 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
17415460 RGD
involved in regulation of T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
15606609 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10931192 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dpp4 Protein Structure

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (105 - 478)

Peptidase_S9

Peptidase_S9: pfam00326 (559 - 763)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 4

  • DPP IV

  • GP110 glycoprotein

  • T-cell activation antigen CD26

  • bile canaliculus domain-specific membrane glycoprotein

  • dipeptidyl peptidase IV

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13749 Sitagliptin Inhibitor 99.94% Yes
HY-10284 Linagliptin 99.74% Unkown
HY-13749A Sitagliptin phosphate Inhibitor 99.88% Yes
HY-10285 Saxagliptin Inhibitor 99.96% Yes
HY-A0023A Alogliptin Inhibitor 99.93% Unkown
HY-14806B Teneligliptin hydrobromide hydrate 99.97% Unkown
HY-14806 Teneligliptin Inhibitor 99.79% Unkown
HY-14806A Teneligliptin hydrobromide 99.99% Unkown
HY-15408 Trelagliptin Inhibitor 99.81% Unkown
HY-15981 Omarigliptin Inhibitor 99.96% Unkown
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.83% Yes
HY-14877 Anagliptin Inhibitor 99.92% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.98% Unkown
HY-15408A Trelagliptin succinate Inhibitor 99.87% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 99.52% Unkown
HY-108795 Albiglutide fragment Agonist 99.86% Unkown
HY-16448 Saxagliptin hydrochloride Inhibitor 99.54% Yes
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% Yes
HY-14892 Gemigliptin Inhibitor / Unkown
HY-13749AR Sitagliptin phosphate (Standard) Inhibitor 99.82% Unkown
HY-108795A Albiglutide fragment TFA Agonist 99.12% Unkown
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
HY-13749E Sitagliptin hydrochloride Inhibitor / Unkown
HY-13749R Sitagliptin (Standard) Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5311 Albiglutide Agonist 99.92% Unkown
HY-P9805 Anti-MERS-3A1 mAb Inhibitor ≥99.0% Unkown
HY-P9806 Anti-MERS-D12 mAb Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-14806S Teneligliptin-d8 Inhibitor / Phase 4
HY-117985 Evogliptin / Phase 4
HY-112668 Retagliptin phosphate Inhibitor 99.71% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.29% Phase 3
HY-10286 Dutogliptin Inhibitor 99.21% Phase 3
HY-123377 Fotagliptin Inhibitor 99.05% Phase 3
HY-12528 DBPR108 Inhibitor 99.93% Phase 3
HY-125330 Denagliptin tosylate Inhibitor / Phase 3
HY-171454 DA-1241 Agonist 99.18% Phase 2
HY-10288 Melogliptin Inhibitor / Phase 2
HY-121029 Bisegliptin / Phase 2
HY-139792 Besigliptin tosylate / Phase 2
HY-122188 TAK-100 Inhibitor / Phase 1
HY-16656 BMS-767778 Inhibitor / Phase 1
HY-109060 Garvagliptin Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991551 YS110 99.75% Phase 2
HY-P991445 REGN3051 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1141 GLP-1(9-36)amide Antagonist 99.69% Unkown
HY-117985B Evogliptin tartrate 98.11% Unkown
HY-112668A Retagliptin Inhibitor 98.51% Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.61% Unkown
HY-N6079 Timosaponin A1 Inhibitor 99.70% Unkown
HY-P4344 Met-Gly-Pro-AMC Substrate 99.74% Unkown
HY-10284S Linagliptin-d4 99.9% Unkown
HY-14892B Gemigliptin tartrate hydrate Inhibitor 99.83% Unkown
HY-W003222 N-tert-Boc-cis-4-fluoro-L-proline 99.0% Unkown
HY-13749AS Sitagliptin-d4 phosphate Inhibitor 99.48% Unkown
HY-13749S1 Sitagliptin-d4 hydrochloride Inhibitor 99.36% Unkown
HY-158315 NZ-97 Inhibitor 99.43% Unkown
HY-123377A Fotagliptin benzoate Inhibitor 99.19% Unkown
HY-147401 Sitagliptin fenilalanil Inhibitor 99.57% Unkown
HY-131250 N-Boc-Sitagliptin 98.87% Unkown
HY-RS03963 DPP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W003592A L-Orinithine lactam hydrochloride 97.0% Unkown
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-A0023AS Alogliptin-13C,d3 Inhibitor / Unkown
HY-A0023AS2 Alogliptin-13C,d3 benzoate Inhibitor 98.77% Unkown
HY-I0786 (2S,4R)-Teneligliptin Inhibitor / Unkown
HY-10286A Dutogliptin tartrate Inhibitor / Unkown
HY-112668B Retagliptin hydrochloride Inhibitor / Unkown
HY-117985A Evogliptin hydrochloride Inhibitor / Unkown
HY-170569 Cetagliptin / Unkown
HY-10284S1 Linagliptin-13C,d3 / Unkown
HY-10284S3 Linagliptin-d3-1 / Unkown
HY-10285S Saxagliptin-15N,d2 hydrochloride Inhibitor / Unkown
HY-10287A Gosogliptin hydrochloride Inhibitor / Unkown
HY-103432 DPP4-In / Unkown
HY-111294 ASP4000 hydrochloride Inhibitor / Unkown
HY-117985BS Evogliptin-d9 tartrate / Unkown
HY-13749C (S)-Sitagliptin phosphate Inhibitor / Unkown
HY-13749S2 Sitagliptin-d4 Inhibitor / Unkown
HY-146455 DPP-4-IN-3 Inhibitor / Unkown
HY-146468 DPP-4/GPR119 modulator 1 / Unkown
HY-146469 DPP-4/GPR119 modulator 2 / Unkown
HY-14806S1 Teneligliptin-d4 Inhibitor / Unkown
HY-14892C Gemigliptin hydrochloride Inhibitor / Unkown
HY-151383 DPP-4-IN-1 Inhibitor / Unkown
HY-151384 DPP-4-IN-2 Inhibitor / Unkown
HY-153522 ZY15557 Inhibitor / Unkown
HY-15408S Trelagliptin-13C,d3 Inhibitor / Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-155961 Antidiabetic agent 2 Inhibitor / Unkown
HY-157390 DPP-4-IN-9 Inhibitor / Unkown
HY-159491 DPP-4-IN-11 Inhibitor / Unkown
HY-161428 ZINC000003015356 Inhibitor / Unkown
HY-162513 DPP-4-IN-10 Inhibitor / Unkown
HY-168621 DPP-4-IN-13 Inhibitor / Unkown
HY-169110 DPP-4-IN-12 Inhibitor / Unkown
HY-170572 PB01 Inhibitor / Unkown
HY-170657 DPP-4-IN-14 Inhibitor / Unkown
HY-176000 Sulphostin Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-179473 MK-0626 / Unkown
HY-182336 DeDPP4 / Unkown
HY-184139 KGDI-109 Inhibitor / Unkown
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / Unkown
HY-P10760 PhAc-ALGP-Dox / Unkown
HY-P11823 FAPα/DPP4 flurogenic substrate-1 / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W741755A 5-Hydroxy saxagliptin hydrochloride Inhibitor / Unkown
HY-W741755S1 5-Hydroxy saxagliptin-13C,d2-2 hydrochloride Inhibitor / Unkown
HY-Z1764 DPP-4-IN-18 Inhibitor / Unkown
HY-10284S4 Linagliptin-d5 / Unkown
HY-10284S5 Linagliptin-d6 / Unkown
HY-10285S2 Saxagliptin-13C2 Inhibitor / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-117985S Evogliptin-d9 / Unkown
HY-119266 HTS13517 Inhibitor / Unkown
HY-132489S (Rac)-Sitagliptin-d4 Inhibitor / Unkown
HY-132489S1 (Rac)-Sitagliptin-d4-1 hydrochloride Inhibitor / Unkown
HY-13749D (Rac)-Sitagliptin Inhibitor / Unkown
HY-13749S3 Sitagliptin-d6 Inhibitor / Unkown
HY-14806S2 Teneligliptin-d5 Inhibitor / Unkown
HY-14877S1 Anagliptin-d7 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-167680 Denagliptin / Unkown
HY-170800 DPP-4-IN-15 Inhibitor / Unkown
HY-174832 DPP-4-IN-16 Inhibitor / Unkown
HY-175590 DPP-4-IN-17 Inhibitor / Unkown
HY-180527 SGLT2-IN-5 Inhibitor / Unkown
HY-180528 SGLT2-IN-6 Inhibitor / Unkown
HY-A0299A H-Gly-Pro-Hyp-OH acetate Inhibitor 99.9% Unkown
HY-N4069 Lupinalbin A / Unkown
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor 99.70% Unkown
HY-Z3637 (–)-Sitagliptin carbamoyl glucuronide Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp4 NCBI NCBI:1803