2. NF-κB
    Metabolic Enzyme/Protease
  3. NF-κB
    Dipeptidyl Peptidase
  4. NDMC101

NDMC101 

Cat. No.: HY-124958 Purity: 99.59%
COA Handling Instructions

NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al.

For research use only. We do not sell to patients.

NDMC101 Chemical Structure

NDMC101 Chemical Structure

CAS No. : 1308631-40-4

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Based on 1 publication(s) in Google Scholar

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Description

NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al[1].

In Vitro

NDMC101 (10-15 µM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells[1].
NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

265.67

Appearance

Solid

Formula

C13H9ClFNO2
CAS No.
SMILES

OC1=C(C=CC=C1)C(NC2=CC=C(C=C2F)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (376.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7641 mL 18.8203 mL 37.6407 mL
5 mM 0.7528 mL 3.7641 mL 7.5281 mL
10 mM 0.3764 mL 1.8820 mL 3.7641 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.41 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NDMC1011308631-40-4NDMC 101NDMC-101NF-κBDipeptidyl PeptidaseNuclear factor-κBNuclear factor-kappaBDPPBonerheumatoid arthritisosteoblastNSAIDRAW 264.7marrow-derived macrophagessynovial inflammationbone destruction,Inhibitorinhibitorinhibit

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