1. NF-κB
    Metabolic Enzyme/Protease
  2. NF-κB
    Dipeptidyl Peptidase
  3. NDMC101

NDMC101 

Cat. No.: HY-124958
Handling Instructions

NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al.

For research use only. We do not sell to patients.

NDMC101 Chemical Structure

NDMC101 Chemical Structure

CAS No. : 1308631-40-4

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Description

NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene express. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al[1].

In Vitro

NDMC101 (10-15 µM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells[1].
NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1Acp5CtskOscarItgb3, and Dcstamp in BMDMs[1].

Molecular Weight

265.67

Formula

C₁₃H₉ClFNO₂

CAS No.

1308631-40-4

SMILES

OC1=C(C=CC=C1)C(NC2=CC=C(C=C2F)Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NDMC101NDMC 101NDMC-101NF-κBDipeptidyl PeptidaseNuclear factor-κBNuclear factor-kappaBDPPBonerheumatoid arthritisosteoblastNSAIDRAW 264.7marrow-derived macrophagessynovial inflammationbone destruction,Inhibitorinhibitorinhibit

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NDMC101
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