1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. DBPR108

DBPR108 

Cat. No.: HY-12528 Purity: 99.90%
Handling Instructions

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.

For research use only. We do not sell to patients.

DBPR108 Chemical Structure

DBPR108 Chemical Structure

CAS No. : 1186426-66-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 396 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

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Description

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 nM [1] Target: DPP4 inhibitor DBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus.

Clinical Trial
Molecular Weight

324.39

Formula

C₁₆H₂₅FN₄O₂

CAS No.
SMILES

N#C[[email protected]]1N(C(CNC(C)(C)CC(N2CCCC2)=O)=O)C[[email protected]@H](F)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (77.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0827 mL 15.4135 mL 30.8271 mL
5 mM 0.6165 mL 3.0827 mL 6.1654 mL
10 mM 0.3083 mL 1.5414 mL 3.0827 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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Keywords:

DBPR108DBPR 108DBPR-108Dipeptidyl PeptidaseDPPInhibitorinhibitorinhibit

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Product Name:
DBPR108
Cat. No.:
HY-12528
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