Saxagliptin hydrochloride
Based on 6 publication(s) in Google Scholar
Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 709031-78-7
- Formula: C18H26ClN3O2
- Molecular Weight:351.87
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Saxagliptin hydrochloride
More- Int J Biol Macromol. 2024 Oct;278(Pt 2):134783. [Abstract]
- Biochem Pharmacol. 2020 Jul:177:113951. [Abstract]
- J Mol Cell Cardiol. 2026 Jan 19:213:14-30. [Abstract]
- J Biol Chem. 2018 Dec 7;293(49):18864-18878. [Abstract]
- Andrology. 2023 Feb;11(2):295-306. [Abstract]
- Front Oncol. 2021 Sep 24:11:728047. [Abstract]
Biological Activity
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DPP-4 |
Saxagliptin (100 nM; 48 hours; INS-1 832/13 cells) treatment significantly induceS β-cell proliferation[1].
Saxagliptin (100 nM; 48 hours; INS-1 832/13 cells) treatment increases the p-AKT and active β-catenin protein levels, paralleled with the increase of c-myc and cyclin D1 protein expression[1].
Saxagliptin acts by preventing the degradation of glucagon-like peptide-1 and hence increases secretion of insulin and decreases secretion of glucagon[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:INS-1 832/13 cells
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Concentration:100 nM
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Incubation Time:48 hours
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Result:Significantly induced β-cell proliferation.
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Cell Line:INS-1 832/13 cells
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Concentration:100 nM
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Incubation Time:48 hours
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Result:Increased the p-AKT and active β-catenin protein levels, paralleled with the increase of c-myc and cyclin D1 protein expression.
Saxagliptin dose-dependently inhibits plasma DPP-4 activity in Han-Wistar rats, by ~70% at 7 hours postdose with 1 mg/kg and by ~90% at 7 hours postdose with 10 mg/kg. At 24 hours postdose, ~20% and 70% inhibition, respectively, remained[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 709031-78-7
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Appearance Solid
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Molecular Weight 351.87
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Formula C18H26ClN3O2
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Color White to off-white
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SMILES
N[C@@H]([C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23O)C(N([C@@H](C4)C#N)[C@@H]5[C@H]4C5)=O.[H]Cl
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Synonyms
BMS-477118 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
An acidic polysaccharide promoting GLP-1 secretion from Dendrobium huoshanense protocorm-like bodies: Structure validation and activity exploration. [Abstract]2024 Oct;278(Pt 2):134783. PMID: 39153673 -
Biochem Pharmacol
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. [Abstract]2020 Jul:177:113951. PMID: 32251672 -
J Mol Cell Cardiol
DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progression by ferritinophagy. [Abstract]2026 Jan 19:213:14-30. PMID: 41565199 -
J Biol Chem
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. [Abstract]2018 Dec 7;293(49):18864-18878. PMID: 30291141 -
Andrology
Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus. [Abstract]2023 Feb;11(2):295-306. PMID: 36113503 -
Front Oncol
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]2021 Sep 24:11:728047. PMID: 34631556
Solvent & Solubility
DMSO : 125 mg/mL (355.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (284.20 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Chun-Jun Li, et al. Saxagliptin Induces β-Cell Proliferation through Increasing Stromal Cell-Derived Factor-1α In Vivo and In Vitro. Front Endocrinol (Lausanne). 2017 Nov 27;8:326. [Content Brief]
[2]. Darshan J Dave. Saxagliptin: A dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus. J Pharmacol Pharmacother. 2011 Oct;2(4):230-5. [Content Brief]
[3]. Carolyn F Deacon, et al. Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther. 2009 May;26(5):488-99. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.8420 mL | 14.2098 mL | 28.4196 mL | 71.0490 mL |
| 5 mM | 0.5684 mL | 2.8420 mL | 5.6839 mL | 14.2098 mL | |
| 10 mM | 0.2842 mL | 1.4210 mL | 2.8420 mL | 7.1049 mL | |
| 15 mM | 0.1895 mL | 0.9473 mL | 1.8946 mL | 4.7366 mL | |
| 20 mM | 0.1421 mL | 0.7105 mL | 1.4210 mL | 3.5524 mL | |
| 25 mM | 0.1137 mL | 0.5684 mL | 1.1368 mL | 2.8420 mL | |
| 30 mM | 0.0947 mL | 0.4737 mL | 0.9473 mL | 2.3683 mL | |
| 40 mM | 0.0710 mL | 0.3552 mL | 0.7105 mL | 1.7762 mL | |
| 50 mM | 0.0568 mL | 0.2842 mL | 0.5684 mL | 1.4210 mL | |
| 60 mM | 0.0474 mL | 0.2368 mL | 0.4737 mL | 1.1841 mL | |
| 80 mM | 0.0355 mL | 0.1776 mL | 0.3552 mL | 0.8881 mL | |
| 100 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7105 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Saxagliptin hydrochloride Related Classifications
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