DPP4 - dipeptidyl peptidase 4 Gene

Also Known as CD26; ADABP; ADCP2; DPPIV; TP103

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1803

About DPP4

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,992,245-162,074,215 (from NCBI)

This gene has 23 transcripts (splice variants), 286 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues.

Summary

The DPP4 gene encodes Dipeptidyl Peptidase 4, which is identical to Adenosine Deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II Transmembrane Glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl Peptidase 4 is highly involved in glucose and Insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

DPP4 Products (8)

mRNA	Protein	Name
NM_001935.4	NP_001926.2	dipeptidyl peptidase 4 isoform 1
NR_166823.1
NM_001379605.1	NP_001366534.1	dipeptidyl peptidase 4 isoform 3
NM_001379604.1	NP_001366533.1	dipeptidyl peptidase 4 isoform 2
NR_166825.1
NM_001379606.1	NP_001366535.1	dipeptidyl peptidase 4 isoform 4
NR_166824.1
NR_166822.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	23677473	GOA
enables chemorepellent activity	IMP IMP: Inferred from mutant phenotype	23677473	GOA
enables dipeptidyl-peptidase activity	IDA IDA: Inferred from direct assay	10593948	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22001206	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	16651416	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7594462	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14684150	GOA
enables serine-type endopeptidase activity	EXP EXP: Inferred from Experiment	8100523	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	14684150	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10900005	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	23486063	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	7594462	GOA
involved in T cell costimulation	IDA IDA: Inferred from direct assay	10900005	GOA
involved in endothelial cell migration	IDA IDA: Inferred from direct assay	16651416	GOA
involved in negative regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	16651416	GOA
involved in negative regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	23677473	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17549790	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	27198182	GOA
involved in regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11772392	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16670267	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15052268	GOA
located in cell surface	IDA IDA: Inferred from direct assay	7594462	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	10900005	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	16651416	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16670267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP4 Protein Structure

DPPIV_N

Peptidase_S9

0
200
400
600
766 a.a.

Protein Preferred Names	Protein Names
dipeptidyl peptidase 4	ADCP-2 DPP IV Gly-Pro naphthylamidase Post-proline dipeptidyl aminopeptidase IV T-cell activation antigen CD26 Xaa-Pro-dipeptidylaminopeptidase adenosine deaminase complexing protein 2 dipeptidyl peptidase IV dipeptidylpeptidase 4 dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

DPP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DPP4	P27487	CXCL2	Homo sapiens	P19875	Protease Assay	21314817
Intra	DPP4	P27487	CXCL2	Homo sapiens	P19875	Enzymatic Study	18275857
Cross	DPP4	P27487	S	Human MERS coronavirus	A0A2R4KP93	Filter Binding	29669833
Cross	DPP4	P27487	S	Human MERS coronavirus	A0A2R4KP93	Alpha-Screen	29669833
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	Comigration in SDS	23835475
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	GMS	23835475
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	X-Ray Diffraction	23835475
Intra	DPP4	P27487	CXCL10	Homo sapiens	P02778	Enzymatic Study	18275857
Intra	DPP4	P27487	CXCL11	Homo sapiens	O14625	Protease Assay	21314817
Intra	DPP4	P27487	CCL11	Homo sapiens	P51671	Enzymatic Study	18275857
Intra	DPP4	P27487	CXCL10	Homo sapiens	P02778	Protease Assay	21314817
Intra	DPP4	P27487	DPP4	Homo sapiens	P27487	CD	22001206
Intra	DPP4	P27487	VIP	Homo sapiens	P01282	Protease Assay	21314817
Intra	DPP4	P27487	GCG	Homo sapiens	P01275	Protease Assay	21314817
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	SPR	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Filter Binding	29669833
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Alpha-Screen	29669833
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	FACS	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Confocal	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	FACS	32203189
Cross	DPP4	P27487	ADA	Bos taurus	P56658	SPR	22001206

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70017	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His)	P27487 (N29-P766)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72975	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293)	P27487 (N29-P766)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P72976	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc)	P27487 (N29-P766)	≥ 95%, as determined by reducing SDS-PAGE.

DPP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81529	CD26 Antibody (YA1274)	IHC-P	Human
HY-P81529A	CD26 Antibody (YA1274)(PBS only)	IHC-P	Human
HY-P82766	CD26 Antibody (YA2511)	WB	Human, Mouse, Rat
HY-P84979	CD26 Antibody (YA4671)	ELISA, FC	Human

Related Diseases

Diseases	Alias
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Pancreatic Colloid Cystadenoma	Mucinous Cystadenoma Of Pancreas
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Diabetes Mellitus, Ketosis-Prone	Diabetic Ketoacidosis KPD Diabetes Mellitus, Ketosis-Prone, Susceptibility To Ketosis-Prone Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetic Ketoacidosis Nos Dka - [Diabetic Ketoacidosis] Nos Dka - [Diabetic Ketoacidosis] Without Coma Dka - [Diabetic Ketoacidosis] With Coma
Residual Stage Of Open Angle Glaucoma	Open-Angle Glaucoma Residual Stage
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Squamous Cell Bile Duct Carcinoma	Bile Duct Squamous Cell Carcinoma
Coronavirus Infectious Disease
Vulvovaginitis	Vulvo-Vaginitis
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Hyperinsulinism	Hyperinsulinemia
Autoimmune Disease Of Endocrine System
Acquired Metabolic Disease
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Bullous Pemphigoid	Benign Pemphigus Senile Dermatitis Herpetiformis Old Age Pemphigus Parapemphigus Pemphigoid Pemphigoid Bullous Pemphigoid, Bullous
Balanitis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Intermediate Coronary Syndrome	Unstable Angina Angina At Rest Anginal Chest Pain At Rest Impending Infarction Preinfarction Angina Worsening Angina Angina, Unstable Myocardial Preinfarction Syndrome Angina Unstable Crescendo Angina Angina Decubitus Acute Coronary Insufficiency Unstable Angina Pectoris Preinfarctional Angina Pectoris Worsening Effort Angina Preinfarction Syndrome Unstable Angina Pectoris Syndrome Unstable Anginal Attack Unstable Cardiac Angina Unstable Chest Angina Unstable Heart Angina De Novo Effort Angina Pectoris Crescendo Angina Pectoris Ua - [Unstable Angina]
Psoriasis
Lymphoblastic Lymphoma	Lymphoma, Lymphoblastic Lymphoma Lymphoblastic Precursor Cell Lymphoblastic Lymphoma Precursor Cell Lymphoblastic Leukemia Lymphoma
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Carbohydrate Metabolic Disorder	Inborn Errors Of Carbohydrate Metabolism Disorder Of Carbohydrate Metabolism Carbohydrate Metabolism, Inborn Errors Disorder Of Carbohydrate Transport And Metabolism Inborn Carbohydrate Metabolism Disorder Inborn Carbohydrate Metabolic Disorder Carbohydrate Metabolism Disorder Carbohydrate Metabolism Disorders Disorders Of Carbohydrate Metabolism Congenital Disorders Of Carbohydrate Metabolism Inherited Disorders Of Carbohydrate Metabolism
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Diabetic Autonomic Neuropathy	Diabetic Neuropathies
Hypoglycemic Coma
Glucose Metabolism Disease	Glucose Metabolism Disorders Disorder Of Glucose Metabolism
Diabetes Mellitus	Diabetes
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti
Inherited Metabolic Disorder	Inborn Errors Of Metabolism Inborn Metabolism Disorder Metabolic Hereditary Disorder Inborn Error Of Metabolism Inborn Metabolic Disorder Metabolism, Inborn Errors
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Adenosquamous Bile Duct Carcinoma	Bile Duct Adenosquamous Carcinoma
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Balanoposthitis	Balanitis Due To Infection
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Prediabetes Syndrome	Impaired Glucose Tolerance Prediabetes Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Peripheral Artery Disease	Peripheral Arterial Disease Peripheral Arterial Diseases
Hyperglycemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13749	Sitagliptin	Inhibitor	99.94%	Yes
HY-10284	Linagliptin		99.74%	Unkown
HY-13749A	Sitagliptin phosphate	Inhibitor	99.88%	Yes
HY-10285	Saxagliptin	Inhibitor	99.96%	Yes
HY-A0023A	Alogliptin	Inhibitor	99.93%	Unkown
HY-14806B	Teneligliptin hydrobromide hydrate		99.97%	Unkown
HY-14806	Teneligliptin	Inhibitor	99.79%	Unkown
HY-14806A	Teneligliptin hydrobromide		99.99%	Unkown
HY-15408	Trelagliptin	Inhibitor	99.81%	Unkown
HY-15981	Omarigliptin	Inhibitor	99.96%	Unkown
HY-13749B	Sitagliptin phosphate monohydrate	Inhibitor	99.83%	Yes
HY-14877	Anagliptin	Inhibitor	99.92%	Unkown
HY-A0023	Alogliptin Benzoate	Inhibitor	99.98%	Unkown
HY-15408A	Trelagliptin succinate	Inhibitor	99.87%	Unkown
HY-108795	Albiglutide fragment	Agonist	99.86%	Unkown
HY-16448	Saxagliptin hydrochloride	Inhibitor	99.54%	Yes
HY-10285A	Saxagliptin hydrate	Inhibitor	≥99.0%	Yes
HY-14892	Gemigliptin	Inhibitor	/	Unkown
HY-13749AR	Sitagliptin phosphate (Standard)	Inhibitor	99.82%	Unkown
HY-108795A	Albiglutide fragment TFA	Agonist	99.12%	Unkown
HY-14877A	Anagliptin hydrochloride	Inhibitor	/	Unkown
HY-13749E	Sitagliptin hydrochloride	Inhibitor	/	Unkown
HY-13749R	Sitagliptin (Standard)	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5311	Albiglutide	Agonist	99.92%	Unkown
HY-P9805	Anti-MERS-3A1 mAb	Inhibitor	≥99.0%	Unkown
HY-P9806	Anti-MERS-D12 mAb	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117985B	Evogliptin tartrate		98.11%	Phase 4
HY-14806S	Teneligliptin-d8	Inhibitor	/	Phase 4
HY-117985	Evogliptin		/	Phase 4
HY-112668	Retagliptin phosphate	Inhibitor	99.71%	Phase 3
HY-147257	Cofrogliptin	Inhibitor	99.29%	Phase 3
HY-10286	Dutogliptin	Inhibitor	99.21%	Phase 3
HY-10286A	Dutogliptin tartrate	Inhibitor	/	Phase 3
HY-112668B	Retagliptin hydrochloride	Inhibitor	/	Phase 3
HY-125330	Denagliptin tosylate	Inhibitor	/	Phase 3
HY-167680	Denagliptin		/	Phase 3
HY-10288	Melogliptin	Inhibitor	/	Phase 2
HY-139792	Besigliptin tosylate		/	Phase 2
HY-12528	DBPR108	Inhibitor	99.93%	Phase 1
HY-122188	TAK-100	Inhibitor	/	Phase 1
HY-16656	BMS-767778	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991551	YS110		99.75%	Phase 2
HY-P991445	REGN3051	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (92)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1141	GLP-1(9-36)amide	Antagonist	99.69%	Unkown
HY-14892A	Gemigliptin tartrate	Inhibitor	99.52%	Unkown
HY-112668A	Retagliptin	Inhibitor	98.51%	Unkown
HY-P1141A	GLP-1(9-36)amide TFA	Antagonist	98.61%	Unkown
HY-N6079	Timosaponin A1	Inhibitor	99.70%	Unkown
HY-P4344	Met-Gly-Pro-AMC	Substrate	99.74%	Unkown
HY-10284S	Linagliptin-d4		99.9%	Unkown
HY-14892B	Gemigliptin tartrate hydrate	Inhibitor	99.83%	Unkown
HY-W003222	N-tert-Boc-cis-4-fluoro-L-proline		99.0%	Unkown
HY-171454	DA-1241	Agonist	99.18%	Unkown
HY-13749AS	Sitagliptin-d4 phosphate	Inhibitor	99.48%	Unkown
HY-13749S1	Sitagliptin-d4 hydrochloride	Inhibitor	99.36%	Unkown
HY-158315	NZ-97	Inhibitor	99.43%	Unkown
HY-123377A	Fotagliptin benzoate	Inhibitor	99.19%	Unkown
HY-147401	Sitagliptin fenilalanil	Inhibitor	99.57%	Unkown
HY-131250	N-Boc-Sitagliptin		98.87%	Unkown
HY-RS03963	DPP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W003592A	L-Orinithine lactam hydrochloride		97.0%	Unkown
HY-123377	Fotagliptin	Inhibitor	99.05%	Unkown
HY-147401A	Sitagliptin fenilalanil hydrochloride	Inhibitor	98.94%	Unkown
HY-A0023AS1	Alogliptin-d3	Inhibitor	99.61%	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-A0023AS	Alogliptin-13C,d3	Inhibitor	/	Unkown
HY-I0786	(2S,4R)-Teneligliptin	Inhibitor	/	Unkown
HY-117985A	Evogliptin hydrochloride	Inhibitor	/	Unkown
HY-170569	Cetagliptin		/	Unkown
HY-10284S1	Linagliptin-13C,d3		/	Unkown
HY-10284S3	Linagliptin-d3-1		/	Unkown
HY-10285S	Saxagliptin-15N,d2 hydrochloride	Inhibitor	/	Unkown
HY-10287A	Gosogliptin hydrochloride	Inhibitor	/	Unkown
HY-103432	DPP4-In		/	Unkown
HY-111294	ASP4000 hydrochloride	Inhibitor	/	Unkown
HY-117985BS	Evogliptin-d9 tartrate		/	Unkown
HY-121029	Bisegliptin		/	Unkown
HY-13749C	(S)-Sitagliptin phosphate	Inhibitor	/	Unkown
HY-13749S2	Sitagliptin-d4	Inhibitor	/	Unkown
HY-146455	DPP-4-IN-3	Inhibitor	/	Unkown
HY-146468	DPP-4/GPR119 modulator 1		/	Unkown
HY-146469	DPP-4/GPR119 modulator 2		/	Unkown
HY-14806S1	Teneligliptin-d4	Inhibitor	/	Unkown
HY-14892C	Gemigliptin hydrochloride	Inhibitor	/	Unkown
HY-151383	DPP-4-IN-1	Inhibitor	/	Unkown
HY-151384	DPP-4-IN-2	Inhibitor	/	Unkown
HY-153522	ZY15557	Inhibitor	/	Unkown
HY-15408S	Trelagliptin-13C,d3	Inhibitor	/	Unkown
HY-155027	DPP-4-IN-8	Inhibitor	/	Unkown
HY-155961	Antidiabetic agent 2	Inhibitor	/	Unkown
HY-157390	DPP-4-IN-9	Inhibitor	/	Unkown
HY-159491	DPP-4-IN-11	Inhibitor	/	Unkown
HY-161428	ZINC000003015356	Inhibitor	/	Unkown
HY-162513	DPP-4-IN-10	Inhibitor	/	Unkown
HY-163332	MPO-IN-6	Inhibitor	/	Unkown
HY-168621	DPP-4-IN-13	Inhibitor	/	Unkown
HY-169110	DPP-4-IN-12	Inhibitor	/	Unkown
HY-170572	PB01	Inhibitor	/	Unkown
HY-170657	DPP-4-IN-14	Inhibitor	/	Unkown
HY-176000	Sulphostin	Inhibitor	/	Unkown
HY-179348	DPP9-IN-2		/	Unkown
HY-179473	MK-0626		/	Unkown
HY-182336	DeDPP4		/	Unkown
HY-184139	KGDI-109	Inhibitor	/	Unkown
HY-N9725	16-Hydroxycleroda-3,13-dien-15,16-olide	Inhibitor	/	Unkown
HY-P10760	PhAc-ALGP-Dox		/	Unkown
HY-P11823	FAPα/DPP4 flurogenic substrate-1		/	Unkown
HY-P6177	SGP8	Inhibitor	/	Unkown
HY-RS03964	Dpp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03965	Dpp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W741755A	5-Hydroxy saxagliptin hydrochloride	Inhibitor	/	Unkown
HY-W741755S1	5-Hydroxy saxagliptin-13C,d2-2 hydrochloride	Inhibitor	/	Unkown
HY-Z1764	DPP-4-IN-18	Inhibitor	/	Unkown
HY-10284S4	Linagliptin-d5		/	Unkown
HY-10284S5	Linagliptin-d6		/	Unkown
HY-10285S2	Saxagliptin-13C2	Inhibitor	/	Unkown
HY-109060	Garvagliptin	Inhibitor	/	Unkown
HY-110051	DPP4-In hydrochloride		/	Unkown
HY-117985S	Evogliptin-d9		/	Unkown
HY-119266	HTS13517	Inhibitor	/	Unkown
HY-132489S	(Rac)-Sitagliptin-d4	Inhibitor	/	Unkown
HY-132489S1	(Rac)-Sitagliptin-d4-1 hydrochloride	Inhibitor	/	Unkown
HY-13749D	(Rac)-Sitagliptin	Inhibitor	/	Unkown
HY-13749S3	Sitagliptin-d6	Inhibitor	/	Unkown
HY-14806S2	Teneligliptin-d5	Inhibitor	/	Unkown
HY-14877S1	Anagliptin-d7	Inhibitor	/	Unkown
HY-170800	DPP-4-IN-15	Inhibitor	/	Unkown
HY-174832	DPP-4-IN-16	Inhibitor	/	Unkown
HY-175590	DPP-4-IN-17	Inhibitor	/	Unkown
HY-180527	SGLT2-IN-5	Inhibitor	/	Unkown
HY-180528	SGLT2-IN-6	Inhibitor	/	Unkown
HY-A0299A	H-Gly-Pro-Hyp-OH acetate	Inhibitor	99.9%	Unkown
HY-N4069	Lupinalbin A		/	Unkown
HY-N8134	2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one	Inhibitor	99.70%	Unkown
HY-Z3637	(–)-Sitagliptin carbamoyl glucuronide	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DPP4	RGD	RGD:2515
Bos taurus	DPP4	VGNC	VGNC:106715
Canis familiaris	DPP4	VGNC	VGNC:40074
Felis catus	DPP4	VGNC	VGNC:61604
Mus musculus	DPP4	MGD	MGI:94919
Macaca mulatta	DPP4	VGNC	VGNC:71979
Others	DPP4	NCBI