Besigliptin tosylate
Besigliptin tosylate (SHR117887) is a DPP-4 inhibitor with activity to improve metabolic control and β-cell function. Besigliptin tosylate can effectively reduce serum DPP-4 activity and improve oral glucose tolerance. Besigliptin tosylate significantly reduces fasting blood glucose levels and improves lipid profiles in a diabetic mouse model. The effect of besigliptin tosylate is comparable to that of the known compound vildagliptin (HY-14291) at the same concentration. Besigliptin tosylate increases insulin staining of pancreatic islet cells in chronic administration, indicating improved β-cell function.
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- CAS No.: 1177460-72-8
- Formula: C25H36FN5O5S
- Molecular Weight:537.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1177460-72-8
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Molecular Weight 537.65
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Formula C25H36FN5O5S
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SMILES
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(N2[C@@H](C[C@@H](C2)F)C#N)CN[C@@]3(C[C@]4([H])[C@@](C3)([H])CN(C4)C(N(C)C)=O)C
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Synonyms
SHR117887
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Besigliptin tosylate Related Classifications
HY-139792 Related Classifications
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