2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. SGLT Dipeptidyl Peptidase
  4. SGLT2-IN-6

SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 6.7, and 72 nM respectively. SGLT2-IN-6 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-6 can be used for the study of type 2 diabetes.

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SGLT2-IN-6

SGLT2-IN-6 Chemical Structure

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SGLT2-IN-6 Related Antibodies

Top Publications Citing Use of Products

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SGLT1 SGLT2

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

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Description

SGLT2-IN-6 (Compound 101) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 6.7, and 72 nM respectively. SGLT2-IN-6 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-6 can be used for the study of type 2 diabetes[1].

IC50 & Target[1]

SGLT2

0.8 nM (IC50)

SGLT1

6.7 nM (IC50)

DPP-4

72 nM (IC50)

Molecular Weight

629.73

Formula

C34H45F2N3O6
SMILES

FC1(F)CN(C(CNC(C)(CCCOC2=CC=C(CC3=CC([C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C)O)O)O)=CC=C3CC)C=C2)C)=O)[C@H](C#N)C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGLT2-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGLT2-IN-6SGLTDipeptidyl PeptidaseSodium-dependent glucose cotransportersDPPDPP4 inhibitordual inhibitortype 2 diabetespharmacokineticspharmacodynamicsglucose toleranceurinary glucose excretionGLP-1Inhibitorinhibitorinhibit

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HY-180528
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