2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. IP-10/CXCL10

IP-10/CXCL10

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CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer. CXCL10 activates T lymphocytes (Th1), NK cells, macrophages, dendritic and B cells. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, angiogenesis, immune dysfunction and tumor development[1]. Human CXCL10 gene, is initially isolated in 1985 by Luster while treating a lymphoma cell line (U937) with recombinant IFN-γ. CXCL10 cDNA has an open reading frame of 1173-bp containing 4 exons and encoding a protein of 98-amino acids. The primary translational product of the CXCL10 gene is a 12 kDa protein containing two internal disulfide cross bridges. CXCL10 exerts its biological effects by binding to CXCR3, a seven trans-membrane-spanning G protein-coupled receptor in a paracrine or autocrine fashion, which is predominantly expressed on activated T, B lymphocyte, natural killer (NK), dendritic and macrophage cells. CXCL10 induction depends predominantly on the carboxyl-terminal region of CXCR3, which is essential for CXCR3 internalization, chemotaxis and calcium mobilization induced by the CXCL10 ligand. The powerful chemotactic action of CXCL10 on activated lymphocytes allows it to modulate both innate and adaptive immunity, inducing tissue damage and modulating tumor formation[1].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7226
    IP-10/CRG-2/CXCL10 Protein, Human

    rHuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    		Human E. coli
    CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer. IP-10/CRG-2/CXCL10 Protein, Human consists of 77 amino acids (V22-P98) and is expressed in E. coli.
  • HY-P7225
    IP-10/CRG-2/CXCL10 Protein, Rat (HEK293)

    rRtIP-10/CRG-2/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    		Rat HEK293
    CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer. IP-10/CRG-2/CXCL10 Protein, Rat (HEK293) consists of 77 amino acids (I22-P98) and is expressed in HEK293 cells.
  • HY-P700041AF
    Animal-Free IP-10/CRG-2/CXCL10 Protein, Human (His)

    IP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    		Human E. coli
    The IP-10/CRG-2/CXCL10 protein is a pro-inflammatory cytokine involved in a variety of biological processes, including chemotaxis, immune cell activation, growth regulation, apoptosis, and vasostatic regulation. During viral infection, IP-10 crucially stimulates immune cell activation and migration to the site of infection. Animal-Free IP-10/CRG-2/CXCL10 Protein, Human (His) is the recombinant human-derived animal-FreeIP-10/CRG-2/CXCL10 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IP-10/CRG-2/CXCL10 Protein, Human (His) is 77 a.a., with molecular weight of ~9.45 kDa.
  • HY-P71883A
    CXCL10 Protein, Rhesus macaque (His)

    CXCL10; SCYB10C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

    		Rhesus Macaque E. coli
    CXCL10 protein acts as a chemotactic factor for monocytes and T-lymphocytes, playing a crucial role in their migration in response to inflammatory signals. Through binding to CXCR3, CXCL10 selectively attracts monocytes and T-lymphocytes, positioning it as a key player in immune responses, contributing to the recruitment and activation of these immune cells in various physiological and pathological contexts. CXCL10 Protein, Rhesus macaque (His) is the recombinant Rhesus Macaque-derived CXCL10 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CXCL10 Protein, Rhesus macaque (His) is 77 a.a., with molecular weight of ~11 kDa.
  • HY-P7227
    IP-10/CRG-2/CXCL10 Protein, Mouse

    rMuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1

    		Mouse E. coli
    CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer. IP-10/CRG-2/CXCL10 Protein, Mouse consists of 77 amino acids (I22-P98) and is expressed in E. coli.
  • HY-P74797
    IP-10/CRG-2/CXCL10 Protein, Rat (P.pastoris, His)

    CXCL10; C-X-C motif chemokine 10; Gamma-IP10; IP-10; Mob1; Scyb10

    		Rat P. pastoris
    CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. CXCL10 exerts its biological effects by binding to CXCR3. CXCL10 is a pleiotropic molecule capable of exerting potent biological functions, including promoting the chemotactic activity of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation as well as angiogenesis in infectious and inflammatory diseases and cancer. IP-10/CRG-2/CXCL10 Protein, Rat (P.pastoris, His) is produced in P.pastoris with a C-Terminal His-tag. It consists of 77 amino acids (I22-P98).
  • HY-P700168AF
    Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His)

    IP-10; Gamma-Interferon Inducible Protein 10; Crg-2

    		Mouse E. coli
    The IP-10/CRG-2/CXCL10 Protein, a pro-inflammatory cytokine, modulates immune cells, cell growth, apoptosis, and angiostatic effects. Crucial during viral infections, it activates and migrates immune cells to infected sites by binding to CXCR3. Mechanistically, it triggers G protein-mediated signaling, activating the phospholipase C-dependent pathway, increasing intracellular calcium, and reorganizing actin. This axis also aids neuronal response to brain injury by activating microglia. The IP-10/CRG-2/CXCL10 Protein can exist as a monomer, dimer, or tetramer and interacts with the CXCR3 receptor. Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIP-10/CRG-2/CXCL10 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free IP-10/CRG-2/CXCL10 Protein, Mouse (His) is 77 a.a., with molecular weight of ~9.47 kDa.
  • HY-P700232AF
    Animal-Free IP-10/CRG-2/CXCL10 Protein, Pig (His)

    CXCL10; C-X-C motif chemokine 10; Gamma-IP10; IP-10; Mob1; Scyb10

    		Pig E. coli
    The IP-10/CRG-2/CXCL10 protein is part of the intercrine α family and functions as a chemokine involved in intercellular communication and immune responses. Further studies may contribute to the regulation of inflammatory processes and cellular interactions and will be critical to uncovering specific functions and effects within the broader CxC family of chemokines. Animal-Free IP-10/CRG-2/CXCL10 Protein, Pig (His) is the recombinant pig-derived animal-FreeIP-10/CRG-2/CXCL10 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IP-10/CRG-2/CXCL10 Protein, Pig (His) is 82 a.a., with molecular weight of ~10.13 kDa.
  • HY-P700532
    IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc)

    CXCL10; SCYB10C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

    		Human HEK293
    IP-10/CRG-2/CXCL10 Protein, a pro-inflammatory cytokine, participates in diverse biological processes, including chemotaxis, immune cell activation, growth regulation, apoptosis, and angiostatic modulation. During viral infections, IP-10 crucially stimulates immune cell activation and migration to infected sites. Mechanistically, its binding to CXCR3 activates G protein-mediated signaling, leading to calcium production and actin reorganization. This cascade recruits Th1 lymphocytes to inflammation sites. In neurons, IP-10 responds to brain injury by activating microglia, crucial for neuronal reorganization. Existing in monomeric, dimeric, and tetrameric forms, IP-10 interacts with CXCR3 through its N-terminus. IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc) is the recombinant human-derived IP-10/CRG-2/CXCL10 protein, expressed by HEK293, with N-Myc, N-6*His labeled tag. The total length of IP-10/CRG-2/CXCL10 Protein, Human (HEK293, His-Myc) is 77 a.a., with molecular weight of 12.6 kDa.
  • HY-P700533
    IP-10/CRG-2/CXCL10 Protein, Human (P. pastoris, His)

    CXCL10; SCYB10C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

    		Human P. pastoris
    IP-10/CRG-2/CXCL10 Protein, a pro-inflammatory cytokine, participates in diverse biological processes, including chemotaxis, immune cell activation, growth regulation, apoptosis, and angiostatic modulation. During viral infections, IP-10 crucially stimulates immune cell activation and migration to infected sites. Mechanistically, its binding to CXCR3 activates G protein-mediated signaling, leading to calcium production and actin reorganization. This cascade recruits Th1 lymphocytes to inflammation sites. In neurons, IP-10 responds to brain injury by activating microglia, crucial for neuronal reorganization. Existing in monomeric, dimeric, and tetrameric forms, IP-10 interacts with CXCR3 through its N-terminus. IP-10/CRG-2/CXCL10 Protein, Human (P. pastoris, His) is the recombinant human-derived IP-10/CRG-2/CXCL10 protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of IP-10/CRG-2/CXCL10 Protein, Human (P. pastoris, His) is 77 a.a., with molecular weight of 10.6 kDa.
  • HY-P700980
    CXCL10 Protein, Cynomolgus (His)

    C-X-C motif chemokine 10; IP-10; CXCL10(1-73); CXCL10; INP10; SCYB10; C7; crg-2; gIP-10; IFI10;

    		Cynomolgus E. coli
    CXCL10 protein acts as a chemotactic factor for monocytes and T-lymphocytes, playing a crucial role in their migration in response to inflammatory signals. Through binding to CXCR3, CXCL10 selectively attracts monocytes and T-lymphocytes, positioning it as a key player in immune responses, contributing to the recruitment and activation of these immune cells in various physiological and pathological contexts. CXCL10 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived CXCL10 protein, expressed by E. coli , with N-His labeled tag. The total length of CXCL10 Protein, Cynomolgus (His) is 65 a.a., with molecular weight of 12-14 kDa.
Cat. No. Product Name Effect Purity