ASP4000 hydrochloride
ASP4000 hydrochloride is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 hydrochloride reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 hydrochloride can be used in studies related to type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 851389-35-0
- Formula: C12H18ClN3O2
- Molecular Weight:271.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
DPP-4 2.25 nM (IC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zucker fatty rats (male, 12-13 weeks old, Type 2 diabetes model)[1]
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Dosage:0.01 mg/kg; 0.1 mg/kg
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Administration:p.o.; single dose 30 min prior to refeeding
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Result:Improved glucose tolerance in a dose-dependent manner.
Almost completely inhibited postprandial hyperglycemia at 0.1 mg/kg, significantly decreasing the Δ plasma glucose AUC (between 30 min and 120 min).
Significantly increased plasma Δ active GLP-1 levels constitutively for 120 min after refeeding at both doses, with the 0.1 mg/kg dose producing a larger increase in Δ active GLP-1 AUC.
Showed no significant difference in plasma Δ insulin levels and AUC compared to vehicle-treated rats.
Chemical Information
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CAS No. 851389-35-0
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Molecular Weight 271.74
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Formula C12H18ClN3O2
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SMILES
O=C([C@@H]1[C@H]2C[C@H]([C@H](O)C2)N1)N3[C@@H](CCC3)C#N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ASP4000 hydrochloride Related Classifications
HY-111294 Related Classifications
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