851389-35-0
Chemical Structure
ASP4000 hydrochloride
- CAS No.: 851389-35-0
- Formula:C12H18ClN3O2
- Molecular Weight:271.74
IUPAC Name: (S)-1-((1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-3-carbonyl)pyrrolidine-2-carbonitrile hydrochloride
InChIKey: HBURXUXZLKNVTI-QSWPLQKNSA-N
SMILES: O=C([C@@H]1[C@H]2C[C@H]([C@H](O)C2)N1)N3[C@@H](CCC3)C#N.Cl
Biological Activity: ASP4000 hydrochloride is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 hydrochloride reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 hydrochloride can be used in studies related to type 2 diabetes[1].
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ASP4000 hydrochloride | ASP4000 hydrochloride is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 hydrochloride reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 hydrochloride can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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