2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CXC Chemokines
  6. MIP-2/GRO-beta

MIP-2/GRO-beta

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CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis[1][2]. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 binds to the G-protein coupled receptor CXCR2 (IL-8RB) expressed on macrophages, neutrophils, and epithelial cells and its classical function is to act as chemotactic factors attracting neutrophils to sites of injury[2][3].
In enterocytes, LPS induces CXCL2 expression and promotes migration of neutrophils in a model of platelet-activating factor induced shock and bowel injury. In acute lung injury, CXCR2 ligands, including CXCL1/2/3, have chemotactic effects for polymorphonuclear leukocytes[4]. CXCL2 could provoke a dose-dependent increase of colorectal tumor cell migration in vitro. Further, according to Bachmeier et al., CXCL-1 and −2 silencing could down-regulate several metastasis-promoting genes and inhibit the metastatic potential of breast cancer cells[5].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7258
    MIP-2/CXCL2 Protein, Mouse

    rMuMIP-2/CXCL2; C-X-C motif chemokine 2; SCYB2

    		Mouse E. coli
    CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. MIP-2/CXCL2 Protein, Mouse is produced in E. coli, and consists of 74 amino acids (A27-N100).
  • HY-P7190
    GRO-beta/CXCL2 Protein, Human

    rHuGRO-β/CXCL2; C-X-C motif chemokine 2; MIP2-alpha; HSF

    		Human E. coli
    CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. GRO-beta/CXCL2 Protein, Human is produced in E. coli, and consists of 73 amino acids (A35-N107).
  • HY-P700045AF
    Animal-Free GRO-beta/CXCL2 Protein, Human (His)

    GRO-β/CXCL2; C-X-C motif chemokine 2; MIP2-alpha; HSF

    		Human E. coli
    GRO-beta/CXCL2 Protein, generated by activated monocytes and neutrophils, is prominently expressed at inflammatory sites. Notably, this chemokine, with hematoregulatory properties, suppresses hematopoietic progenitor cell proliferation in vitro. GRO-beta(5-73) displays heightened hematopoietic activity, emphasizing its significant role in regulating hematopoiesis. Animal-Free GRO-beta/CXCL2 Protein, Human (His) is the recombinant human-derived animal-FreeGRO-beta/CXCL2 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free GRO-beta/CXCL2 Protein, Human (His) is 73 a.a., with molecular weight of ~8.7 kDa.
  • HY-P700171AF
    Animal-Free MIP-2/CXCL2 Protein, Mouse (His)

    rMuMIP-2/CXCL2; C-X-C motif chemokine 2; SCYB2

    		Mouse E. coli
    MIP-2/CXCL2 protein selectively attracts polymorphonuclear leukocytes without inducing chemotaxis or oxidative burst. Its chemotactic function coordinates the directional migration of polymorphonuclear leukocytes and contributes to their recruitment in response to inflammatory signals. Animal-Free MIP-2/CXCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMIP-2/CXCL2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free MIP-2/CXCL2 Protein, Mouse (His) is 73 a.a., with molecular weight of ~8.66 kDa.
  • HY-P7191
    GRO-beta/CXCL2 Protein, Rat

    rRtGRO-β/CXCL2; MIP-2; CINC-3; C-X-C motif chemokine 2

    		Rat E. coli
    CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. GRO-beta/CXCL2 Protein, Rat is produced in E. coli, and consists of 69 amino acids (A32-N100).
  • HY-P75154
    MIP-2/CXCL2 Protein, Mouse (His-SUMO)

    C-X-C motif chemokine 2; MIP2; Cxcl2; Scyb2

    		Mouse E. coli
    CXCL2, also called Gro-beta or MIP-2, is a pro-inflammatory cytokine with chemotactic activities on neutrophils. CXCL2 is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis. MIP-2/CXCL2 Protein, Mouse (His-SUMO) is produced in E. coli with a N-Terminal His-tag and a N-Terminal SUMO-tag. It consists of 73 amino acids (A28-N100).
  • HY-P700534
    MIP-2/CXCL2 Protein, Mouse (His)

    rHuGRO-β/CXCL2; C-X-C motif chemokine 2; MIP2-alpha; HSF

    		Mouse E. coli
    MIP-2/CXCL2 protein selectively attracts polymorphonuclear leukocytes without inducing chemotaxis or oxidative burst. Its chemotactic function coordinates the directional migration of polymorphonuclear leukocytes and contributes to their recruitment in response to inflammatory signals. MIP-2/CXCL2 Protein, Mouse (His) is the recombinant mouse-derived MIP-2/CXCL2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MIP-2/CXCL2 Protein, Mouse (His) is 73 a.a., with molecular weight of 11.8 kDa.
Cat. No. Product Name Effect Purity