N-Boc-Sitagliptin
Based on 1 Customer Validation
N-Boc-Sitagliptin is an intermediate in the synthesis of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 486460-23-5
- Formula: C21H23F6N5O3
- Molecular Weight:507.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 486460-23-5
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Appearance Solid
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Molecular Weight 507.43
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Formula C21H23F6N5O3
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Color White to off-white
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SMILES
FC(F)(C1=NN=C2N1CCN(C(C[C@H](NC(OC(C)(C)C)=O)CC3=C(C=C(C(F)=C3)F)F)=O)C2)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (98.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (245 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9707 mL | 9.8536 mL | 19.7072 mL | 49.2679 mL |
| 5 mM | 0.3941 mL | 1.9707 mL | 3.9414 mL | 9.8536 mL | |
| 10 mM | 0.1971 mL | 0.9854 mL | 1.9707 mL | 4.9268 mL | |
| 15 mM | 0.1314 mL | 0.6569 mL | 1.3138 mL | 3.2845 mL | |
| 20 mM | 0.0985 mL | 0.4927 mL | 0.9854 mL | 2.4634 mL | |
| 25 mM | 0.0788 mL | 0.3941 mL | 0.7883 mL | 1.9707 mL | |
| 30 mM | 0.0657 mL | 0.3285 mL | 0.6569 mL | 1.6423 mL | |
| 40 mM | 0.0493 mL | 0.2463 mL | 0.4927 mL | 1.2317 mL | |
| 50 mM | 0.0394 mL | 0.1971 mL | 0.3941 mL | 0.9854 mL | |
| 60 mM | 0.0328 mL | 0.1642 mL | 0.3285 mL | 0.8211 mL | |
| 80 mM | 0.0246 mL | 0.1232 mL | 0.2463 mL | 0.6158 mL |
N-Boc-Sitagliptin Related Classifications
HY-131250 Related Classifications
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