2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Perospirone hydrochloride

Perospirone hydrochloride  (Synonyms: SM-9018)

Art. -Nr.: HY-B0731 Reinheit: 99.94%
COA
SDS
Handling Instructions Technical Support

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

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Perospirone hydrochloride

Perospirone hydrochloride Chemische Struktur

CAS. Nr. : 129273-38-7

Größe Preis Verfügbarkeit Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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25 mg Auf Lager
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Other Forms of Perospirone hydrochloride:

Perospirone hydrochloride Related Antibodies

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Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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Beschreibung

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT1A Receptor

 

5-HT2A Receptor

 

5-HT2A Receptor

0.6 nM (Ki)

D2 Receptor

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

D1 Receptor

41 nM (Ki)

Klinische Studie
Molekulargewicht

463.04

Formel

C23H31ClN4O2S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (269.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1596 mL 10.7982 mL 21.5964 mL
5 mM 0.4319 mL 2.1596 mL 4.3193 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.94%

SDS (392 KB)

COA (246 KB) HNMR (268 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1596 mL 10.7982 mL 21.5964 mL 53.9910 mL
5 mM 0.4319 mL 2.1596 mL 4.3193 mL 10.7982 mL
10 mM 0.2160 mL 1.0798 mL 2.1596 mL 5.3991 mL
15 mM 0.1440 mL 0.7199 mL 1.4398 mL 3.5994 mL
20 mM 0.1080 mL 0.5399 mL 1.0798 mL 2.6996 mL
25 mM 0.0864 mL 0.4319 mL 0.8639 mL 2.1596 mL
30 mM 0.0720 mL 0.3599 mL 0.7199 mL 1.7997 mL
40 mM 0.0540 mL 0.2700 mL 0.5399 mL 1.3498 mL
50 mM 0.0432 mL 0.2160 mL 0.4319 mL 1.0798 mL
60 mM 0.0360 mL 0.1800 mL 0.3599 mL 0.8999 mL
80 mM 0.0270 mL 0.1350 mL 0.2700 mL 0.6749 mL
100 mM 0.0216 mL 0.1080 mL 0.2160 mL 0.5399 mL
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Perospirone hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perospirone129273-38-7SM-9018SM9018SM 90185-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrallyatypicalantipsychoticschizophrenicdiseasecognitive5-HT2A5-HT1AD2-receptorInhibitorinhibitorinhibit

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