2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Protein kinase inhibitor H-7

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC.

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Protein kinase inhibitor H-7 Chemical Structure

Protein kinase inhibitor H-7 Chemical Structure

CAS No. : 84477-87-2

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5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].

IC50 & Target[1]

PKC

6 μM (Ki)

Molecular Weight

291.37

Formula

C14H17N3O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (343.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4321 mL 17.1603 mL 34.3206 mL
5 mM 0.6864 mL 3.4321 mL 6.8641 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4321 mL 17.1603 mL 34.3206 mL 85.8016 mL
5 mM 0.6864 mL 3.4321 mL 6.8641 mL 17.1603 mL
10 mM 0.3432 mL 1.7160 mL 3.4321 mL 8.5802 mL
15 mM 0.2288 mL 1.1440 mL 2.2880 mL 5.7201 mL
20 mM 0.1716 mL 0.8580 mL 1.7160 mL 4.2901 mL
25 mM 0.1373 mL 0.6864 mL 1.3728 mL 3.4321 mL
30 mM 0.1144 mL 0.5720 mL 1.1440 mL 2.8601 mL
40 mM 0.0858 mL 0.4290 mL 0.8580 mL 2.1450 mL
50 mM 0.0686 mL 0.3432 mL 0.6864 mL 1.7160 mL
60 mM 0.0572 mL 0.2860 mL 0.5720 mL 1.4300 mL
80 mM 0.0429 mL 0.2145 mL 0.4290 mL 1.0725 mL
100 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.8580 mL
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Protein kinase inhibitor H-7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protein kinase inhibitor H-784477-87-2Protein kinase inhibitor H7Protein kinase inhibitor H 7PKCProtein kinase CInhibitorinhibitorinhibit

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