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  4. Saponins

Saponins (Saponin) is a class of chemical compound of glycosides found in particular abundance in various plant species. In plants, Saponins may serve as anti-feedants, and to protect the plant against microbes and fungi.

For research use only. We do not sell to patients.

CAS No. : 8047-15-2

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Based on 5 publication(s) in Google Scholar

Saponins Related Antibodies

Top Publications Citing Use of Products

    Saponins purchased from MedChemExpress. Usage Cited in: Alzheimers Res Ther. 2025 Dec 1;17(1):253.  [Abstract]

    Glutamate (20 μM) exposure significantly increased neuronal mitochondrial Ca²⁺ levels (shown by Rhod-2 fluorescence, representative graph scale bar: 20 μm). Detection: Neurons cultured 12–14 DIV were loaded with 2 μM Rhod-2-AM + 0.02% Pluronic F-127 (dark, RT, 30 min), washed, then incubated at 37°C for 30 min. Cells were permeabilized with 0.005% Saponins (1 min), rinsed with Ca²⁺-free HBSS, and finally bathed in extracellular buffer.

    Saponins purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Nov 29;12(12):1115.  [Abstract]

    The mitochondrial calcium uptake assay in primary myoblasts from mice gastrocnemius muscle. The fluorescent dye Rhod-2/AM and Mito-Tracker Green were used to measure primary myoblasts mitochondrial Ca2+ uptake, Briefly, primary myoblasts were loaded with Rhod-2/AM and Mito-Tracker Green following the protocol, permeabilized with 0.005% Saponins for ~1 min, then incubated in Ca2+-free HBSS. Images were acquired at 2 frames/s using a spinning-disk confocal super-resolution microscope (excitation 549 nm, emission 578 nm). After 15 s, the buffer was switched to 5 μmol/L CaCl₂ solution, and imaging continued for an additional 50 s.

    Saponins purchased from MedChemExpress. Usage Cited in: J Med Entomol. 2021 May 15;58(3):1202-1209.  [Abstract]

    Transduction of P2C-EGFP-Cas9 RNP complex into Culex pipiens pallens ovaries. From left to right: P2C-EGFP-Cas9 + sgRNAs + chloroquine (n = 9); P2C-EGFP-Cas9 + sgRNAs + Saponins (n = 13); Wild-type (WT; n = 4). Scale bar: 1 mm. RNP, ribonucleoprotein; sgRNAs, single-guide RNAs.

    Saponins purchased from MedChemExpress. Usage Cited in: J Med Entomol. 2021 May 15;58(3):1202-1209.  [Abstract]

    Delivery efficiency of P2C-enhanced green fluorescent protein (EGFP)-Cas9 ribonucleoprotein with single-guide RNA and ERR.
    Chl., Chloroquine; Sa., Saponins (50 mg/L; 1 μL); ERR, endosomal release reagent; PBM, post-bloodmeal
    #Injection mixture (Inj. Mix) = P2C-Cas9+sgRNAs+ERR (Chloroquine or Saponin).
    asgRNA935; bsgRNA936; csgRNA938.

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    Description

    Saponins (Saponin) is a class of chemical compound of glycosides found in particular abundance in various plant species. In plants, Saponins may serve as anti-feedants, and to protect the plant against microbes and fungi[1].

    In Vitro

    Saponins are glycosides with a distinctive foaming characteristic. Saponins consist of a polycyclic aglycone that is either a choline steroid or triterpenoid attached via C3 and an ether bond to a sugar side chain. The ability of a saponin to foam is caused by the combination of the nonpolar sapogenin and the water soluble side chain. Saponins are bitter and reduce the palatability of livestock feeds. Some saponins reduce the feed intake and growth rate of nonruminant animals while others are not very harmful. For example, the saponins found in oats and spinach increase and accelerate the body's ability to absorb calcium and silicon, thus assisting in digestion. Certain pasture weeds contain substantial quantities of dangerous saponins and result in life threatening toxicities for certain animal species[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Saponins Related Antibodies
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    [Saponins]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 33.33 mg/mL (Need ultrasonic)

    DMSO : 5 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 6.25 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.36%

    SDS (393 KB)

    COA (245 KB)

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    Saponins Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Saponins8047-15-2SaponinFungalEnvironmental PollutantsBacterialEnvironmental ContaminantsInhibitorinhibitorinhibit

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