Search Result

Isoforms Recommended:	AMPKα

Results for "

AMPKα1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adiponectin Receptor (1) Adrenergic Receptor (4) Akt (8) AMPK (33) Amyloid-β (3) Apoptosis (11) Autophagy (4) Cholinesterase (ChE) (1) Drug Metabolite (1) DYRK (1) FXR (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (6) JAK (3) JNK (3) MARK (2) MDM-2/p53 (1) Mitochondrial Metabolism (2) mTOR (2) NF-κB (1) NOD-like Receptor (NLR) (1) p38 MAPK (5) PD-1/PD-L1 (1) PGC-1α (3) PI3K (3) Pim (1) PPAR (2) Pyroptosis (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (6) Reference Standards (4) Salt-inducible Kinase (SIK) (2) Sirtuin (2) STAT (4) Topoisomerase (1) VEGFR (3) β-catenin (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (10) Endocrinology (2) Infection (1) Inflammation/Immunology (5) Metabolic Disease (15) Neurological Disease (3)

By Targets:

Adiponectin Receptor (1)

Adrenergic Receptor (4)

Akt (8)

AMPK (33)

Amyloid-β (3)

Apoptosis (11)

Autophagy (4)

Cholinesterase (ChE) (1)

Drug Metabolite (1)

DYRK (1)

FXR (1)

HDAC (1)

HIF/HIF Prolyl-Hydroxylase (6)

JAK (3)

JNK (3)

MARK (2)

MDM-2/p53 (1)

Mitochondrial Metabolism (2)

mTOR (2)

NF-κB (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (5)

PD-1/PD-L1 (1)

PGC-1α (3)

PI3K (3)

Pim (1)

PPAR (2)

Pyroptosis (1)

Quinone Reductase (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (4)

Salt-inducible Kinase (SIK) (2)

Sirtuin (2)

STAT (4)

Topoisomerase (1)

VEGFR (3)

β-catenin (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (10)

Endocrinology (2)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (15)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N0484

Liensinine Maximum Cited Publications 20 Publications Verification	Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates *AMPK* and inhibits the expression of *HIF-1α* and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke ^[1] .

HY-N3005

Britannin 1 Publications Verification	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology Cancer
Britannin is an NLRP3 inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics ^[1] .

HY-103683

PF-06409577 1 Publications Verification	AMPK	Metabolic Disease
PF-06409577 is a potent and selective allosteric activator of *AMPK* α1β1γ1 isoform with an EC₅₀ of 7 nM.

HY-112769

EX229 5 Publications Verification	AMPK	Metabolic Disease
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase *(AMPK), with K_ds* of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.

HY-151361

AMPK-IN-3 5 Publications Verification	AMPK	Cancer
AMPK-IN-3 (compound 67) is a potent and selective *AMPK* inhibitor with IC₅₀s of 60.7, 107 and 3820 nM for AMPK (α2), **AMPK (α1) and KDR*, respectively. AMPK-IN-3 inhibits AMPK* does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer ^[1].

HY-120877

MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for *MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively ^[1]. MRT199665 causes apoptosis* in MEF2C-activated human acute myeloid leukemias (AML) cells . MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .

HY-N3431

Kaempferol-7-O-rhamnoside	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)	Cardiovascular Disease
Kaempferol-7-O-rhamnoside is a *PD-1/PD-L1* inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure ^[1] .

HY-W073128

Perfluorotetradecanoic acid PFTeDA	PPAR Apoptosis PGC-1α AMPK Akt mTOR Reactive Oxygen Species (ROS)	Endocrinology
Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a K_d value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the *SIRT1/PGC1α* and *AMPK* signaling pathways while stimulating the activity of the *AKT1/mTOR* signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats ^[1] .

HY-115463

EB-3D 2 Publications Verification	AMPK Apoptosis	Cancer
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC₅₀ of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, *AMPK* activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity ^[1] .

HY-16708A

ZLN024 hydrochloride 1 Publications Verification	AMPK	Metabolic Disease
ZLN024 hydrochloride is an *AMPK* allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-117623

PF-06685249 PF-249	AMPK	Metabolic Disease
PF-06685249 (PF-249) is a potent and orally active allosteric *AMPK* activator with an EC₅₀ of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 improves renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 can be used for diabetic nephropathy research ^[1].

HY-A0144A

Etilefrine hydrochloride	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

HY-A0144

Etilefrine	Adrenergic Receptor AMPK Akt	Cardiovascular Disease
Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

HY-103239

PT1	AMPK	Cardiovascular Disease Metabolic Disease
PT1 is an AMPKα1 activator that directly activates the inactive truncated forms of AMPKα1 monomers ^[1].

HY-155943

AMPK-IN-4	AMPK	Cancer
AMPK-IN-4 (compound 19) is a potent inhibitor of (AMPK(α1) and *AMPK*(α2) with IC₅₀s of 393 nM and 141 nM, respectively. AMPK-IN-4 plays an important role in cancer research ^[1].

HY-130479

AdipoR agonist 1	Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK	Metabolic Disease
AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research ^[1].

HY-172157

HDAC11-IN-2	HDAC AMPK	Metabolic Disease
HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC₅₀s of 51.1 ×10 ^-3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver ^[1].

HY-E70648

AMPK alpha 1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK alpha 1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1 proteins ^[1].

HY-16708

ZLN024	AMPK	Metabolic Disease
ZLN024 is an *AMPK* allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC₅₀s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.

HY-170027

LW1564	HIF/HIF Prolyl-Hydroxylase AMPK	Cancer
LW1564 is an inhibitor for *HIF-1α* with an IC₅₀ of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI₅₀ of 0.4-4.6 μM. LW1564 activates *AMPK* signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model ^[1].

HY-120877A

(R)-MRT199665	MARK Salt-inducible Kinase (SIK) AMPK Apoptosis	Cancer
(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective *MARK/SIK/AMPK* inhibitor with IC₅₀s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for *MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis* in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 ^[1] .

HY-E70793

Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ1 proteins and is biotinylated ^[1].

HY-N5014

Liensinine perchlorate Maximum Cited Publications 20 Publications Verification	Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Liensinine perchlorate is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine perchlorate suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine perchlorate activates *AMPK* and inhibits the expression of *HIF-1α* and VEGF, thereby suppressing angiogenesis. Liensinine perchlorate exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine perchlorate can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke ^[1] .

HY-E70787

AMPK α1β1γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK α1β1γ1 Recombinant Human Active Protein Kinase is an ortholog of AMPK. AMPK α1β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ1 proteins ^[1].

HY-147038

AMPK activator 8	AMPK	Metabolic Disease
AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC₅₀s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes ^[1].

HY-E70795

Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ2, and AMPKγ1 proteins and is biotinylated ^[1].

HY-136855

MitoPBN	Sirtuin AMPK PGC-1α Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
MitoPBN is a *AMPK/SIRT3/PGC-1α* axis modulator, reactive oxygen species scavenger and mitochondrial function enhancer. MitoPBN increases the phosphorylation level of *AMPK, restores SIRT3* expression and reverses the down-regulation of *PGC-1α, thereby promoting mitochondrial biogenesis. MitoPBN regulates glucose metabolism, reduces blood glucose by inhibiting hepatic gluconeogenesis and increasing hepatic glucose uptake, while scavenging mitochondrial superoxide anion/hydrogen peroxide, maintaining membrane potential and increasing ATP* production. MitoPBN also reduces cell apoptosis, improves sperm motility, survival rate and membrane integrity, but may induce reductive stress in cryopreserved sperm at high concentrations. MitoPBN is widely applicable to research related to diabetes and type 2 diabetes ^[1] .

HY-157129

AMPK-α1β1γ1 activator 1	AMPK	Cardiovascular Disease
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC₅₀ value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy ^[1].

HY-A0144AR

Etilefrine hydrochloride (Standard)	Reference Standards AMPK Adrenergic Receptor Akt	Cardiovascular Disease
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

HY-A0144R

Etilefrine (Standard)	Adrenergic Receptor AMPK Akt Reference Standards	Cardiovascular Disease
Etilefrine (Standard) is the analytical standard of Etilefrine. This product is intended for research and analytical applications. Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

HY-181077

AMPKα1 activator 1	AMPK	Endocrinology
AMPKα1 activator 1 is a selective and orally active AMPKα1 activator with an EC₅₀ of 35.1 nM. AMPKα1 activator 1 shows 176-fold selectivity over AMPKα2. AMPKα1 activator 1 can be used as a cell protectant and a kidney protectant. AMPKα1 activator 1 attenuates elevation of serum creatinine and blood urea nitrogen levels, alleviates kidney damage, and reduces cellular infiltration in renal ischemia-reperfusion injury contexts. AMPKα1 activator 1 can be associated with renal ischemia-reperfusion injury research ^[1].

HY-120270

PF-06679142	AMPK	Metabolic Disease
PF-06679142 (Compound 10) is a potent, orally active *AMPK* activator with an EC₅₀ of 22 nM against *α1β1γ1-AMPK*. PF-06679142 can be used for diabetic nephropathy research ^[1].

HY-103683R

PF-06409577 (Standard)	Reference Standards AMPK	Metabolic Disease
PF-06409577 (Standard) is the analytical standard of PF-06409577. This product is intended for research and analytical applications. PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

HY-E70794

Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ2 proteins and is biotinylated ^[1].

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of *SIRT1* and *AMPK, and subsequently activate PGC-1α*. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures ^[1] .

HY-N0484R

Liensinine (Standard)	Reference Standards Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt	Cardiovascular Disease Neurological Disease Cancer
Liensinine (Standard) is the analytical standard of Liensinine (HY-N0484). This product is intended for research and analytical applications. Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates *AMPK* and inhibits the expression of *HIF-1α* and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke ^[1] .

HY-W800535

Cryptolepine	NF-κB p38 MAPK mTOR Topoisomerase AMPK Apoptosis Cholinesterase (ChE) HIF/HIF Prolyl-Hydroxylase β-catenin	Infection Metabolic Disease Inflammation/Immunology Cancer
Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of *c-Myc, mTOR, NF-κB, HIF-1, MAPK* and an activator of *AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase* inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection ^[1] .

HY-122670

VS-II-173	Pim Apoptosis AMPK DYRK STAT MDM-2/p53	Cancer
VS-II-173 is a pan-Pim kinase inhibitor with IC₅₀ values of 0.07 μM and 0.02 μM for *Pim1* and Pim3, respectively, and a residual activity of 46% for Pim2 at 1 μM. VS-II-173 also inhibits kinases such as HIPK2, PRK2, *RSK1, DYRK1a* and AMPKα1, selectively inhibiting acute myeloid leukemia (AML) cells with significantly lower toxicity to non-malignant cells (EC₅₀ > 30 μM). VS-II-173 weakens the phosphorylation of substrates such as Stat5 (Y694), MDM2 (S166), Bad (S112), and 4E-BP1 (T37/46) by inhibiting Pim kinase-mediated signaling pathways, blocking pro-survival signals in AML cells and inducing apoptosis. VS-II-173 synergistically enhances anti-AML activity when combined with Daunorubicin (HY-13062A). VS-II-173 can be used in AML research, especially for AML with FLT3-ITD mutations and *NPM1* mutations ^[1] .

HY-134998

Oltipraz metabolite M2	HIF/HIF Prolyl-Hydroxylase Mitochondrial Metabolism Drug Metabolite p38 MAPK	Metabolic Disease Inflammation/Immunology
Oltipraz metabolite M2, an active metabolite of Oltipraz (HY-12519), is an orally active *HIF-1α* inhibitor. Oltipraz metabolite M2 increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating *AMPK* in high-fat diet (HFD)-fed mice. Oltipraz metabolite M2 can be used for hepatic steatosis and steatohepatitis research ^[1] .

Cat. No.	Nombre del producto	Type

HY-A0144A

Etilefrine hydrochloride	Biochemical Assay Reagents
Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

Etilefrine hydrochloride

Biochemical Assay Reagents

Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

HY-A0144AR

Etilefrine hydrochloride (Standard)	Biochemical Assay Reagents
Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the *AMPK/Akt* pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

Etilefrine hydrochloride (Standard)

Biochemical Assay Reagents

Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output ^[1] .

Liensinine Maximum Cited Publications 20 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Alkaloid Dimers Source Classification	Reactive Oxygen Species (ROS) Autophagy Apoptosis VEGFR JAK Amyloid-β p38 MAPK HIF/HIF Prolyl-Hydroxylase STAT PI3K JNK Akt
Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates *AMPK* and inhibits the expression of *HIF-1α* and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke ^[1] .

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis
Britannin is an NLRP3 inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics ^[1] .

Kaempferol-7-O-rhamnoside	Flavonols Flavonoids other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Chimonanthus nitens Oliv. Plants Disease Research Fields Source Classification Calycanthaceae	AMPK PD-1/PD-L1 FXR Reactive Oxygen Species (ROS)
Kaempferol-7-O-rhamnoside is a *PD-1/PD-L1* inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure ^[1] .

Species:	Human (3)
Tag:	His (3) GST (2)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P76141

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (Active, sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; AMPK; AMPK (α1, β1, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of 38 (beta-1)&40 (gamma-1)&95 (alpha-1) kDa, respectively.

HY-P76143

	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (Active, sf9, His-GST) 1 Publications Verification 5'-AMP-activated protein kinase; AMPK; AMPK (α1, β2, γ1) Protein	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) is the recombinant human-derived AMPK gamma 1/beta 2/alpha 1 Heterotrimer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST), has molecular weight of ~35 & 37 & 95 KDa, respectively.

HY-P702896

	AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (Active, sf9, His) AMPK1	Human	Sf9 insect cells
	AMPK gamma 1 is the AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK) and is an important regulator of cellular energy metabolism. It is activated by low ATP levels, enhancing energy production while inhibiting biosynthetic processes and cell growth. AMPK gamma 1/beta 1/alpha 1 Protein, Human (sf9, His) is the recombinant human-derived AMPK gamma 1/beta 1/alpha 1, expressed by Sf9 insect cells, with C-6*His labeled tag.

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Source
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Host:	Mouse (3) Rabbit (5)
Reactivity:	Human (8) Rat (5) Mouse (4) Monkey (2)
Application:	IHC-P (6) ICC/IF (8) IP (4) WB (8) FC (4) ELISA (5)
Isotype:	IgG,Kappa (1) IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (8)
Clonality:	Polyclonal (2) Monoclonal (5) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (5)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P87895

	AMPK α1 Antibody (YA7580)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	AMPK α1 Antibody (YA7580) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to AMPK α1.

HY-P80376

	AMPK alpha 1 Antibody (YA624)	WB, ICC/IF, FC, IP	Human, Rat
	AMPK alpha 1 Antibody (YA624) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AMPK alpha 1.

HY-P84528

	AMPK alpha 1 Antibody (YA4225) AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	AMPK alpha 1 Antibody (YA4225) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 1.

HY-P84528A

	AMPK alpha 1 Antibody (YA4225)(PBS only) AMPK; AMPKa1; MGC33776; MGC57364; PRKAA1	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	AMPK alpha 1 Antibody (YA4225) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AMPK alpha 1.

HY-P80451

	*Phospho-AMPK* alpha 1 (Ser496) Antibody (YA226)**	WB, ICC/IF, IP	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody (YA226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AMPK alpha 1 (Ser496).

HY-P80539

	AMPK alpha 1 Antibody PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	AMPK alpha 1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to AMPK alpha 1.

HY-P85745

	AMPK alpha 1 Antibody (YA5437) PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	AMPK alpha 1 Antibody (YA5437) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AMPK alpha 1.

HY-P80790

	*Phospho-AMPK* alpha 1 (Ser496) Antibody** PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1	WB, IHC-P, ICC/IF	Human
	Phospho-AMPK alpha 1 (Ser496) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AMPK alpha 1 (Ser496).

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