LW1564
LW1564 is an inhibitor for HIF-1α with an IC50 of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI50 of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model.
For research use only. We do not sell to patients.
- CAS No.: 2668337-39-9
- Formula: C42H48F3N3O5
- Molecular Weight:731.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Biological Activity
Chemical Information
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CAS No. 2668337-39-9
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Molecular Weight 731.84
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Formula C42H48F3N3O5
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SMILES
O=C(COC1=CC=C(C23CC4CC(C3)CC(C4)(C2)C(N5CC6=CC(OC)=C(C=C6CC5)OC)=O)C=C1)N7CCN(CC7)CC8=CC=C(C(F)(F)F)C=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LW1564 Related Classifications
HY-170027 Related Classifications
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