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Neuronal Signaling Others NF-κB Protein Tyrosine Kinase/RTK Stem Cell/Wnt PI3K/Akt/mTOR Metabolic Enzyme/Protease Apoptosis JAK/STAT Signaling MAPK/ERK Pathway Immunology/Inflammation Autophagy Epigenetics
PI3K Reference Standards Apoptosis Amyloid-β STAT Akt Autophagy JAK HIF/HIF Prolyl-Hydroxylase JNK Reactive Oxygen Species (ROS) VEGFR p38 MAPK
Liensinine (Standard)

Cat. No.: HY-N0484R

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Liensinine (Standard)

Liensinine (Standard) is the analytical standard of Liensinine (HY-N0484). This product is intended for research and analytical applications. Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke.

For research use only. We do not sell to patients.

CAS No.: 2586-96-1
Formula: C₃₇H₄₂N₂O₆
Molecular Weight:610.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Liensinine (Standard) Chemical Structure

CAS No.: 2586-96-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information
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Chemical Information
Purity & Documentation
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Bioz

Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2586-96-1
Molecular Weight 610.74
Formula C₃₇H₄₂N₂O₆
SMILES

OC1=CC=C(C[C@H]2N(C)CCC3=C2C=C(OC)C(OC)=C3)C=C1OC4=CC5=C(C=C4OC)CCN(C)[C@@H]5CC6=CC=C(O)C=C6
Structure Classification
- Alkaloids
- Alkaloid Dimers
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79. [Content Brief]

[2]. Liang Pang, et al. Protective effect of liensinine on periodontitis through its antioxidant effect in mice. Journal of the Korean Society for Applied Biological Chemistry volume 58, pages927-936

[3]. Shuhua Tong, et al. Pharmacokinetics and bioavailability of liensinine in mouse blood by UPLC-MS/MS. Acta Chromatographica,Volume 33: Issue 4,14 Oct 2020.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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