Cat. No.: HY-N3431

Kaempferol-7-O-rhamnoside

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Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure.

For research use only. We do not sell to patients.

Purity: 99.18%
CAS No.: 20196-89-8
Formula: C₂₁H₂₀O₁₀
Molecular Weight:432.38

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Kaempferol-7-O-rhamnoside Chemical Structure

CAS No.: 20196-89-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

α-glucosidase activity^[1]

All AMPK Isoforms :

In Vitro

Kaempferol-7-O-rhamnoside (24 h) blocks PD-1/PD-L1 interaction in a dose-dependent manner via activating NFAT transcriptional activity in the co-culture system of PD-1 Jurkat cells and PD-L1/aAPC CHO-K1 cells^[1].
Kaempferol-7-O-rhamnoside (100-500 μM) exerts no significant cytotoxicity on H9c2 cardiomyocytes, and effectively protects H9c2 cardiomyocytes against H2O2-induced damage, as evidenced by the improvement of cell viability^[2].
Kaempferol-7-O-rhamnoside (100-500 μM) significantly upregulates the mRNA expression level of AMPKα1 in H9c2 cardiomyocytes, with a strong positive correlation between its concentration and AMPKα1 expression^[2].
Kaempferol-7-O-rhamnoside (25-100 μM, 24 h) inhibits AST and AKP activities in APAP-induced L02 cells^[3].
Kaempferol-7-O-rhamnoside (100 μM, 24 h) significantly reduces the increase of ROS production in APAP-induced L02 cells^[3].
Kaempferol-7-O-rhamnoside (25-100 μmol/L, 24 h) significantly up-regulates the mRNA expression of FXR and down-regulates the mRNA expression of Cyp7a1 in APAP-induced L02 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 20196-89-8
Appearance Solid
Molecular Weight 432.38
Formula C₂₁H₂₀O₁₀
Color Off-white to yellow
SMILES

O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@@H]([C@H]([C@H](C)O4)O)O)O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (231.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3128 mL

11.5639 mL

23.1278 mL

5 mM

0.4626 mL

2.3128 mL

4.6256 mL

10 mM

0.2313 mL

1.1564 mL

2.3128 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JH, et al. Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro. Int J Mol Sci. 2020 May 3;21(9):3239. [Content Brief]

[2]. Li Z, et al. Decoding the anti-heart failure effects of Xinbao Pills: AMPKα1 activation and active compound screening. Phytomedicine. 2025 Sep;145:157016. [Content Brief]

[3]. Liu K, et al. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicol Appl Pharmacol. 2022 Nov 1;454:116251. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3128 mL	11.5639 mL	23.1278 mL	57.8195 mL
	5 mM	0.4626 mL	2.3128 mL	4.6256 mL	11.5639 mL
	10 mM	0.2313 mL	1.1564 mL	2.3128 mL	5.7820 mL
	15 mM	0.1542 mL	0.7709 mL	1.5419 mL	3.8546 mL
	20 mM	0.1156 mL	0.5782 mL	1.1564 mL	2.8910 mL
	25 mM	0.0925 mL	0.4626 mL	0.9251 mL	2.3128 mL
	30 mM	0.0771 mL	0.3855 mL	0.7709 mL	1.9273 mL
	40 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4455 mL
	50 mM	0.0463 mL	0.2313 mL	0.4626 mL	1.1564 mL
	60 mM	0.0385 mL	0.1927 mL	0.3855 mL	0.9637 mL
	80 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7227 mL
	100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.5782 mL

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Kaempferol-7-O-rhamnoside

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All AMPK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Kaempferol-7-O-rhamnoside Related Classifications

HY-N3431 Related Classifications