1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. NCGC00092410

NCGC00092410 

Cat. No.: HY-114043 Purity: 99.72%
Handling Instructions

NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease.

For research use only. We do not sell to patients.

NCGC00092410 Chemical Structure

NCGC00092410 Chemical Structure

CAS No. : 442898-34-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
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100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease[1].

IC50 & Target

IC50: 31 nM (glucocerebrosidase)[1]

In Vitro

NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner[1].
NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts[1].
NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.46

Formula

C₂₁H₂₇N₃O₂

CAS No.

442898-34-2

SMILES

O=C(C1CCCCC1)NC2=CC=C3N=C(N4CCOCC4)C=C(C)C3=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (117.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8292 mL 14.1459 mL 28.2917 mL
5 mM 0.5658 mL 2.8292 mL 5.6583 mL
10 mM 0.2829 mL 1.4146 mL 2.8292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NCGC00092410NCGC 00092410NCGC-00092410GlucosidaseglucocerebrosidaseGCchaperoneGaucherInhibitorinhibitorinhibit

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NCGC00092410
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HY-114043
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