442898-34-2
Chemical Structure
NCGC00092410
- CAS No.: 442898-34-2
- Formula:C21H27N3O2
- Molecular Weight:353.46
IUPAC Name: N-(4-methyl-2-morpholinoquinolin-6-yl)cyclohexanecarboxamide
InChIKey: BXVNPOBNVRBOOV-UHFFFAOYSA-N
SMILES: O=C(C1CCCCC1)NC2=CC=C3N=C(N4CCOCC4)C=C(C)C3=C2
Biological Activity: NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease[1].
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NCGC00092410 | 98.10% | NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease. | ||||||||||||||||||||
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