20196-89-8
Chemical Structure
Kaempferol-7-O-rhamnoside
- CAS No.: 20196-89-8
- Formula:C21H20O10
- Molecular Weight:432.38
IUPAC Name: 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: HQNOUCSPWAGQND-GKLNBGJFSA-N
SMILES: O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@@H]([C@H]([C@H](C)O4)O)O)O)=CC(O)=C13
Biological Activity: Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kaempferol-7-O-rhamnoside | 99.18% | Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure. | ||||||||||||||||||||
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References
- [1]. Kim JH, et al. Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro. Int J Mol Sci. 2020 May 3;21(9):3239. [Content Brief]
- [2]. Li Z, et al. Decoding the anti-heart failure effects of Xinbao Pills: AMPKα1 activation and active compound screening. Phytomedicine. 2025 Sep;145:157016. [Content Brief]
- [3]. Liu K, et al. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicol Appl Pharmacol. 2022 Nov 1;454:116251. [Content Brief]
