1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. Butyl isobutyl phthalate

Butyl isobutyl phthalate 

Cat. No.: HY-N7377 Purity: 98.77%
Handling Instructions

Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment.

For research use only. We do not sell to patients.

Butyl isobutyl phthalate Chemical Structure

Butyl isobutyl phthalate Chemical Structure

CAS No. : 17851-53-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Description

Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment[1].

IC50 & Target

IC50: 38 μM (α-glucosidase)[1]

In Vitro

Butyl isobutyl phthalate exhibits significant, concentration-dependent inhibitory activity against α-glucosidase with an IC50 value of 38 μM[1].

In Vivo

Butyl isobutyl phthalate (intragastric administration; 25, 50 or 100 mg/kg; 3 days) results in a more significant reduction in the blood glucose level, with the concentration of blood glucose being 11.50, 8.60 and 6.50 mM, respectively[1].

Animal Model: Streptozocin induced diabetic mice (Male Kunming mice)[1]
Dosage: 25, 50 or 100 mg/kg
Administration: Intragastric administration
Result: Had the observed antidiabetes activity in mice.
Molecular Weight

278.34

Formula

C₁₆H₂₂O₄

CAS No.

17851-53-5

SMILES

O=C(C1=CC=CC=C1C(OCC(C)C)=O)OCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (898.18 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5927 mL 17.9636 mL 35.9273 mL
5 mM 0.7185 mL 3.5927 mL 7.1855 mL
10 mM 0.3593 mL 1.7964 mL 3.5927 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (8.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (8.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (8.08 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Butyl isobutyl phthalateGlucosidaseα-glucosidasehypoglycemicdiabeteInhibitorinhibitorinhibit

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Butyl isobutyl phthalate
Cat. No.:
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