1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK
  3. AMPK-IN-3

AMPK-IN-3 

Cat. No.: HY-151361
Handling Instructions

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer.

For research use only. We do not sell to patients.

AMPK-IN-3 Chemical Structure

AMPK-IN-3 Chemical Structure

CAS No. : 2417674-27-0

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Description

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1].

IC50 & Target[1]

AMPK (α2)

60.7 nM (IC50)

AMPK (α1)

107 nM (IC50)

KDR

3820 nM (IC50)

In Vitro

AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively[1].
AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 µM; 2 h) decreases the level of p-ACC in K562 cells[1].
AMPK-IN-3 (1-100 µM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 0.195313, 0.78125, 3.125, 12.5, 50 µM
Incubation Time: 2 h
Result: Decreased cellular levels of p-ACC(Ser79) in K562 cells.

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 1-100 µM
Incubation Time: 24, 48, 72 h
Result: Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours.
Molecular Weight

451.56

Formula

C25H33N5O3

CAS No.
SMILES

O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(CC)CC)=O)=C(N3)C)C)NC1=CC=C2CCC(N)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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AMPK-IN-3
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HY-151361
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