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B2176

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36

Inhibitors & Agonists

4

Biochemical Assay Reagents

10

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8

Isotope-Labeled Compounds

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2176
    ATP
    Maximum Cited Publications
    152 Publications Verification

    Adenosine 5'-triphosphate

    		 Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Infection Metabolic Disease Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
    ATP
  • HY-B2176A
    ATP disodium trihydrate
    Maximum Cited Publications
    152 Publications Verification

    Adenosine-5'-triphosphate disodium trihydrate

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation .
    ATP disodium trihydrate
  • HY-B2176B
    ATP dimagnesium
    Maximum Cited Publications
    152 Publications Verification

    Adenosine 5'-triphosphate dimagnesium

    		 Endogenous Metabolite Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation .
    ATP dimagnesium
  • HY-B2176R
    ATP (Standard)

    Adenosine 5'-triphosphate (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation . In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs .
    ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner .
    ATP promotes neutrophil chemotaxis in vitro .
    In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo .
    ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo .
    ATP (Standard)
  • HY-B2176S6
    ATP-13C10 dilithium

    Adenosine 5'-triphosphate-13C10 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP- 13C10 (Adenosine 5'-triphosphate- 13C10) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-13C10 dilithium
  • HY-B2176I
    ATP disodium salt, 100 mM Solution, PCR Grade
    140+ Cited Publications

    Adenosine 5'-triphosphate disodium salt, 100 mM Solution, PCR Grade

    		 Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Infection Metabolic Disease Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
    ATP disodium salt, 100 mM Solution, PCR Grade
  • HY-B2176S
    ATP-13C10,15N5

    Adenosine 5'-triphosphate-13C10,15N5

    		 Endogenous Metabolite Metabolic Disease
    ATP- 13C10, 15N5 is the 13C and 15N labeled ATP . ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation .
    ATP-13C10,15N5
  • HY-B2176S5
    ATP-15N5 dilithium

    Adenosine 5'-triphosphate-15N5 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP- 15N5 (Adenosine 5'-triphosphate- 15N5) dilithium is 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-15N5 dilithium
  • HY-B2176S4
    ATP-d14 dilithium

    Adenosine 5'-triphosphate-d14 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP-d14 (Adenosine 5'-triphosphate-d14) dilithium is deuterium labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-d14 dilithium
  • HY-B2176S7
    ATP-13C2 dilithium

    Adenosine 5'-triphosphate-13C2 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP- 13C2 (Adenosine 5'-triphosphate- 13C2) dilithium is 13C-labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-13C2 dilithium
  • HY-B2176C
    ATP dipotassium
    140+ Cited Publications

    Adenosine 5'-triphosphate dipotassium

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology Cancer
    ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation .
    ATP dipotassium
  • HY-B2176E
    ATP magnesium
    140+ Cited Publications

    Adenosine 5'-triphosphate magnesium

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation .
    ATP magnesium
  • HY-B2176S3
    ATP-15N5,d14 dilithium

    Adenosine 5'-triphosphate-15N5,d14 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP- 15N5,d14 (Adenosine 5'-triphosphate- 15N5,d14) dilithium is deuterium and 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
    ATP-15N5,d14 dilithium
  • HY-B2176AR
    ATP disodium trihydrate (Standard)

    Adenosine-5'-triphosphate disodium trihydrate (Standard)

    		 Endogenous Metabolite Reference Standards Metabolic Disease Inflammation/Immunology Cancer
    ATP (disodium trihydrate) (Standard) is the analytical standard of ATP (disodium trihydrate). This product is intended for research and analytical applications. ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation .
    ATP disodium trihydrate (Standard)
  • HY-B2176D
    ATP ditromethamine

    Adenosine 5'-triphosphate ditromethamine

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    ATP ditromethamine (Adenosine 5'-triphosphate ditromethamine) is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation .
    ATP ditromethamine
  • HY-B2176BR
    ATP dimagnesium (Standard)

    Adenosine 5'-triphosphate dimagnesium (Standard)

    		 Endogenous Metabolite Reference Standards Inflammation/Immunology
    ATP (dimagnesium) (Standard) is the analytical standard of ATP (dimagnesium). This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation .
    ATP dimagnesium (Standard)
  • HY-B2176S8
    ATP-13C10,15N5,d14 dilithium

    Adenosine 5'-triphosphate-13C10,15N5,d14 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Others
    ATP- 13C10, 15N5,d14 (Adenosine 5'-triphosphate- 13C10, 15N5,d14) dilithium is the 13C-, 15N- and deuterium labeled ATP dilithium. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.
    ATP-13C10,15N5,d14 dilithium
  • HY-N1939
    Icariside I
    3 Publications Verification

    Icarisid I

    		 Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1 Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .
    Icariside I
  • HY-W048491
    2′-O-(2-Methoxyethyl)adenosine

    		DNA/RNA Synthesis Drug Derivative Others
    2′-O-(2-Methoxyethyl)adenosine is an ATP (HY-B2176) derivative. 2′-O-(2-Methoxyethyl)adenosine can be used for oligonucleotide synthesis .
    2′-O-(2-Methoxyethyl)adenosine
  • HY-12700
    RO5256390
    3 Publications Verification

    		 Trace Amine-associated Receptor (TAAR) Neurological Disease
    RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .
    RO5256390
  • HY-150709S1
    Adenosine 5'-triphosphate-13C10,15N5 dilithium

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Adenosine 5'-triphosphate-13C10,15N5 dilithium is 13C and 15N labeled dilithium salt form of Adenosine 5'-triphosphate (HY-B2176). Adenosine 5'-triphosphate is a central component of energy storage and metabolism in vivo. Adenosine 5'-triphosphate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. Adenosine 5'-triphosphate is an important endogenous signaling molecule in immunity and inflammation .
    Adenosine 5'-triphosphate-13C10,15N5 dilithium
  • HY-160645
    P2X4 antagonist-1

    		P2X Receptor Neurological Disease Endocrinology Cancer
    P2X4 antagonist-1 is a P2X4 receptor antagonist with an IC50 of 15 nM. P2X4 antagonist-1 inhibits ATP (HY-B2176)-induced calcium influx. P2X4 antagonist-1 can be used for the research of pain syndromes, endometriosis, cancer .
    P2X4 antagonist-1
  • HY-131789A
    2-NH2-PuTP sodium

    n2h6ATP sodium

    		 Adenylate Cyclase Metabolic Disease
    2-NH2-PuTP (n2h6ATP) sodium, an ATP (HY-B2176) analogue, is a competitive pyruvate-stimulated adenylate cyclase inhibitor with a Ki of 1.7 mM.
    2-NH2-PuTP sodium
  • HY-W011425B
    NTP 25 mM Solution, PCR Grade

    		Biochemical Assay Reagents Others
    NTP 25 mM Solution, PCR Grade is a mixed solution of 25 mM ATP (HY-B2176), 25 mM CTP, 25 mM GTP (HY-113225), and 25 mM UTP (HY-107372). It is free of DNase, RNase, phosphatase, and protease. NTP 25 mM Solution, PCR Grade is suitable for molecular biology research.
    NTP 25 mM Solution, PCR Grade
  • HY-134290
    8-Chloro-ATP

    		Topoisomerase Cancer
    8-Chloro-ATP, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP inhibits Topo II-catalyzed ATP hydrolysis .
    8-Chloro-ATP
  • HY-134290A
    8-Chloro-ATP tetrasodium

    		Topoisomerase Cancer
    8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis .
    8-Chloro-ATP tetrasodium
  • HY-134372A
    Bis-Br-ANT-ATP tetrasodium

    		Adenylate Cyclase Bacterial Infection
    Bis-Br-ANT-ATP (tetrasodium) is a fluorescent derivative of adenosine-5’-triphosphate (ATP) (HY-B2176). Bis-Br-ANT-ATP (tetrasodium) selectively inhibits B. pertussis adenylyl cyclase toxin CyaA (Ki: 12.6 nM). Bis-Br-ANT-ATP (tetrasodium) can be used in Whooping cough research .
    Bis-Br-ANT-ATP tetrasodium
  • HY-134033A
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium

    2'-Fluoro dATP sodium

    		 Nucleoside Antimetabolite/Analog Infection
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176). 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM .
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
  • HY-N1939R
    Icariside I (Standard)

    Icarisid I (Standard)

    		 Reference Standards Apoptosis Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) STAT CDK Bcl-2 Family Aryl Hydrocarbon Receptor JAK Caspase IFNAR PD-1/PD-L1 Inflammation/Immunology Endocrinology Cancer
    Icariside I (Standard) is the analytical standard of Icariside I (HY-N1939). This product is intended for research and analytical applications. Icariside I (GH01) is an orally active metabolite of icalin. Icariside I improves estrogen deficiency-induced osteoporosis by simultaneously regulating osteoblast and osteoclast differentiation. Icariside I promotes ATP (HY-B2176) or Nigericin (HY-127019)-induced mtROS production and NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Icariside I does not alter the activation of NLRC4 and AIM2 inflammasomes. Icariside I inhibits breast cancer proliferation, apoptosis, invasion, and metastasis by targeting the IL-6/STAT3 pathway. Icariside I is a kynurenine-AhR pathway inhibitor that alleviates cancer by blocking tumor immune escape .
    Icariside I (Standard)
  • HY-131774A
    2-AHT-ATP sodium

    2-(6-Aminohexyl)thio-ATP sodium

    		 Nucleoside Antimetabolite/Analog Metabolic Disease
    2-AHT-ATP (2-(6-Aminohexyl)thio-ATP) sodium is a derivative of ATP (HY-B2176). 2-AHT-ATP can be used in the synthesis of biotinylated ATP derivatives .
    2-AHT-ATP sodium
  • HY-173580
    7-Deaza-2'-deoxyadenosine-5'-O-triphosphate tetrasodium

    C7-dATP tetrasodium

    		 Drug Derivative Metabolic Disease
    7-Deaza-2'-deoxyadenosine-5'-O-triphosphate (C7-dATP) tetrasodium is a derivative of ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo .
    7-Deaza-2'-deoxyadenosine-5'-O-triphosphate tetrasodium
  • HY-134248
    Tubercidin 5'-triphosphate

    7-Deazaadenosine 5'-triphosphate

    		 Drug Derivative Myosin Neurological Disease
    Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils .
    Tubercidin 5'-triphosphate
  • HY-134360A
    ATP-1-Aminonaphthalene-5-sulfonate sodium

    (y-AmNS)-ATP sodium

    		 Fluorescent Dye Metabolic Disease
    ATP-1-Aminonaphthalene-5-sulfonate ((y-AmNS)-ATP) sodium is a fluorescent analog of ATP (HY-B2176). ATP-1-Aminonaphthalene-5-sulfonate is a substrate for DNA-dependent RNA polymerase and valyl t-RNA synthetase (Ex/Em = 320/460 nm) .
    ATP-1-Aminonaphthalene-5-sulfonate sodium
  • HY-182513
    ONO-8539

    		Prostaglandin Receptor Others Inflammation/Immunology
    ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP (HY-B2176)-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease .
    ONO-8539
  • HY-186072
    NT-0527

    		NOD-like Receptor (NLR) Interleukin Related Cytochrome P450 Neurological Disease Metabolic Disease Inflammation/Immunology
    NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor. NT-0527 can specifically block the formation of the NLRP3 inflammasome, resulting in the reduction in the maturation and release of IL-1β, exhibit inhibition on CYP2C19. NT-0527 displays anti-inflammatory activity in the mouse LPS (HY-D1056) /ATP (HY-B2176)-induced peritonitis model. NT-0527 can be used for the research of neuroinflammatory disorders (Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis) and peripheral inflammatory disorders (type II diabetes, atherosclerosis, gout, etc.) associated with NLRP3 inflammasome .
    NT-0527
  • HY-W017087
    1,2,4-Trimethoxybenzene

    		NOD-like Receptor (NLR) Caspase Interleukin Related Infection Metabolic Disease
    1,2,4-Trimethoxybenzene is an orally active NLRP3 selective inhibitor. 1,2,4-Trimethoxybenzene can markedly suppress Nigericin (HY-127019) or ATP (HY-B2176)-induced NLRP3 inflammasome activation, thus decreasing caspase-1 activation and IL-1β secretion. 1,2,4-Trimethoxybenzene specifically inhibits the activation of NLRP3 inflammasome without affecting absent in melanoma 2 (AIM2) inflammasome activation. 1,2,4-Trimethoxybenzene inhibits oligomerization of the apoptosis-associated speck-like protein containing a CARD (ASC) and protein-protein interaction between NLRP3 and ASC, thus blocking NLRP3 inflammasome assembly. 1,2,4-Trimethoxybenzene can be used for the study of experimental autoimmune encephalomyelitis (EAE), multiple sclerosis, and type 2 diabetes .
    1,2,4-Trimethoxybenzene

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