ONO-8539
ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP (HY-B2176)-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 459842-29-6
- Fòrmula: C25H28N2O5S2
- Peso molecular:500.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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EP1 |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 459842-29-6
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Peso molecular 500.63
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Fòrmula C25H28N2O5S2
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SMILES
O=C(C1=CC=C(COC2=C(N(S(=O)(C3=NC=CS3)=O)CC(C)C)C=C(CCC4)C4=C2)C(C)=C1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Chapple CR, et al. Phase II study on the efficacy and safety of the EP1 receptor antagonist ONO-8539 for nonneurogenic overactive bladder syndrome. J Urol. 2014;191(1):253-260. [Content Brief]
[2]. Kondo T, et al. A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial. J Gastroenterol. 2017;52(10):1081-1089. [Content Brief]
[3]. Naganawa A, et al. Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists. Bioorg Med Chem. 2006 Dec 1;14(23):7774-89. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ONO-8539 Related Classifications
HY-182513 Related Classifications
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