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Cat. No.: HY-134248

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Tubercidin 5'-triphosphate

(Synonyms: 7-Deazaadenosine 5'-triphosphate)

Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils.

For research use only. We do not sell to patients.

CAS No.: 10058-66-9
Formula: C₁₁H₁₇N₄O₁₃P₃
Molecular Weight:506.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Tubercidin 5'-triphosphate Chemical Structure

CAS No.: 10058-66-9

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Biological Activity

Description

All Myosin Isoforms :

MLCK

In Vitro

Tubercidin 5'-triphosphate (0.15 mM) can be hydrolyzed by rabbit skeletal muscle myosin B under conditions of high ionic strength with Ca²⁺ (0.6 M KCl, 7 mM CaCl₂, pH 7.0, 20°C), and its hydrolysis rate is 49% of that of ATP^[1].
Tubercidin 5'-triphosphate (0.15 mM) can be hydrolyzed by rabbit skeletal muscle myosin B under conditions of low ionic strength with Mg²⁺present (0.075 M KCl, 2 mM MgCl₂, pH 7.0, 20°C), and its hydrolysis rate reaches 270% of that of ATP^[1].
Tubercidin 5'-triphosphate (0.1 mM) induces weak contraction of rabbit psoas myofibrils under the conditions of 0.04 M K⁺Cl⁻, 2 mM MgCl₂, pH 7.0 and 23°C, which is evidenced by the formation of subtle contraction bands^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10058-66-9
Molecular Weight 506.19
Formula C₁₁H₁₇N₄O₁₃P₃
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C3=NC=NC(N)=C3C=C2
Synonyms

7-Deazaadenosine 5'-triphosphate
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tonomura Y, et al. Interaction between synthetic ATP analogues and actomyosin systems. IV. J Biochem. 1967 Apr;61(4):460-72. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tubercidin 5'-triphosphate

All Myosin Isoforms

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Tubercidin 5'-triphosphate Related Classifications

HY-134248 Related Classifications