Tubercidin 5'-triphosphate  (Synonyms: 7-Deazaadenosine 5'-triphosphate)

Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) (Compound II) is an ATP (HY-B2176) analogue. Tubercidin 5'-triphosphate is hydrolyzable by Myosin B. Tubercidin 5'-triphosphate induces weak contraction of rabbit psoas myofibrils^[1].

Tubercidin 5'-triphosphate (0.15 mM) can be hydrolyzed by rabbit skeletal muscle myosin B under conditions of high ionic strength with Ca²⁺ (0.6 M KCl, 7 mM CaCl₂, pH 7.0, 20°C), and its hydrolysis rate is 49% of that of ATP^[1].
Tubercidin 5'-triphosphate (0.15 mM) can be hydrolyzed by rabbit skeletal muscle myosin B under conditions of low ionic strength with Mg²⁺ present (0.075 M KCl, 2 mM MgCl₂, pH 7.0, 20°C), and its hydrolysis rate reaches 270% of that of ATP^[1].
Tubercidin 5'-triphosphate (0.1 mM) induces weak contraction of rabbit psoas myofibrils under the conditions of 0.04 M K⁺Cl⁻, 2 mM MgCl₂, pH 7.0 and 23°C, which is evidenced by the formation of subtle contraction bands^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

506.19

C₁₁H₁₇N₄O₁₃P₃

10058-66-9

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C3=NC=NC(N)=C3C=C2

Room temperature in continental US; may vary elsewhere.

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• [1]. Tonomura Y, et al. Interaction between synthetic ATP analogues and actomyosin systems. IV. J Biochem. 1967 Apr;61(4):460-72.  [Content Brief]