2′-O-(2-Methoxyethyl)adenosine
Based on 1 Customer Validation
2′-O-(2-Methoxyethyl)adenosine is a 2′-O-methoxyethyl derivative of the purine nucleoside adenosine. 2′-O-(2-Methoxyethyl)adenosine is widely used as a synthetic intermediate and pharmacological tool in oligonucleotide chemistry, nucleoside-based drug research, and biochemical studies.
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- Reinheit : 98.37%
- CAS. Nr.: 168427-74-5
- Formel: C13H19N5O5
- Molecular Weight:325.32
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
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HY-W011552
2'-O-MethyladenosineHypertensive Compound -
HY-W406070
2'-O,4'-C-MethyleneguanosineNucleotide -
HY-W570888
2'-O,4'-C-MethylenecytidineNucleoside Analogue -
HY-23789
2′-O-(2-Methoxyethyl)guanosineNucleoside Analogue -
HY-110407
2'-O,4'-C-MethyleneadenosineAdenosine Analog -
HY-N6666
Vidarabine monohydrateAntiviral Agent -
HY-N6666R
Vidarabine monohydrate (Standard)Reference Standard
Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 168427-74-5
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Appearance Solid
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Molecular Weight 325.32
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Formel C13H19N5O5
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](OCCOC)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (153.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.39 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (6.39 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0739 mL | 15.3695 mL | 30.7390 mL | 76.8474 mL |
| 5 mM | 0.6148 mL | 3.0739 mL | 6.1478 mL | 15.3695 mL | |
| 10 mM | 0.3074 mL | 1.5369 mL | 3.0739 mL | 7.6847 mL | |
| 15 mM | 0.2049 mL | 1.0246 mL | 2.0493 mL | 5.1232 mL | |
| 20 mM | 0.1537 mL | 0.7685 mL | 1.5369 mL | 3.8424 mL | |
| 25 mM | 0.1230 mL | 0.6148 mL | 1.2296 mL | 3.0739 mL | |
| 30 mM | 0.1025 mL | 0.5123 mL | 1.0246 mL | 2.5616 mL | |
| 40 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9212 mL | |
| 50 mM | 0.0615 mL | 0.3074 mL | 0.6148 mL | 1.5369 mL | |
| 60 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL | 1.2808 mL | |
| 80 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9606 mL | |
| 100 mM | 0.0307 mL | 0.1537 mL | 0.3074 mL | 0.7685 mL |
2′-O-(2-Methoxyethyl)adenosine Related Classifications
HY-W048491 Related Classifications
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