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Garcinia

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (1) AMPK (1) Apoptosis (5) ATM/ATR (2) ATP Citrate Lyase (3) Aurora Kinase (1) Autophagy (2) Bacterial (5) Bcl-2 Family (2) CDK (2) Cholinesterase (ChE) (2) DNA/RNA Synthesis (1) Drug Derivative (3) Endogenous Metabolite (2) FABP (1) Ferroptosis (1) Glycosidase (1) Hedgehog (2) Histone Acetyltransferase (2) HIV (1) Keap1-Nrf2 (1) Lipase (1) mTOR (1) NF-κB (1) Parasite (3) Phosphodiesterase (PDE) (1) PKC (1) PPAR (1) Proteasome (1) Reactive Oxygen Species (ROS) (1) Reference Standards (6) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) Sirtuin (1) STAT (2)
研究分野別:	Cancer (23) Cardiovascular Disease (2) Endocrinology (1) Infection (9) Inflammation/Immunology (7) Metabolic Disease (7) Neurological Disease (2)

標的別:

5-HT Receptor (1)

AMPK (1)

Apoptosis (5)

ATM/ATR (2)

ATP Citrate Lyase (3)

Aurora Kinase (1)

Autophagy (2)

Bacterial (5)

Bcl-2 Family (2)

CDK (2)

Cholinesterase (ChE) (2)

DNA/RNA Synthesis (1)

Drug Derivative (3)

Endogenous Metabolite (2)

FABP (1)

Ferroptosis (1)

Glycosidase (1)

Hedgehog (2)

Histone Acetyltransferase (2)

HIV (1)

Keap1-Nrf2 (1)

Lipase (1)

mTOR (1)

NF-κB (1)

Parasite (3)

Phosphodiesterase (PDE) (1)

PKC (1)

PPAR (1)

Proteasome (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (6)

Reverse Transcriptase (1)

Ribosomal S6 Kinase (RSK) (1)

Sirtuin (1)

STAT (2)

研究分野別:

Cancer (23)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (9)

Inflammation/Immunology (7)

Metabolic Disease (7)

Neurological Disease (2)

阻害剤およびアゴニスト

生化学アッセイ試薬

天然物

製品番号	製品名	Target	研究分野	構造式

HY-107569

Garcinol 5 Publications Verification	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N0087

Gambogic Acid Maximum Cited Publications 6 Publications Verification Beta-Guttiferrin	Bcl-2 Family Autophagy	Cancer
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N3347

Macurin Maclurin	Others	Others
Macurin is a xanthone that can be isolated from Garcinia lancilimba .

HY-W338584

Hydroxycitric acid tripotassium 1 Publications Verification	Keap1-Nrf2 Ferroptosis Apoptosis mTOR NF-κB ATP Citrate Lyase AMPK Ribosomal S6 Kinase (RSK) DNA/RNA Synthesis	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-N14035

Garcinia cambogia extract	FABP PPAR	Metabolic Disease
Garcinia cambogia extract is an orally active anti-obesity agent . Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels . Garcinia cambogia extract ameliorates high-fat diet-induced obesity .

HY-N6954

Garcinone C 2 Publications Verification	ATM/ATR STAT CDK Hedgehog	Inflammation/Immunology Cancer
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .

HY-N4094

Morellic acid 1 Publications Verification	Others	Inflammation/Immunology
Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .

HY-N2795

9-Hydroxycalabaxanthone Xanthone I	Parasite Bacterial	Infection
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC₅₀=1.2-1.5 μM) .

HY-N5115

Neosmitilbin	Others	Others
Neosmitilbin is isolated from Garcinia mangostana.

HY-N6248

Cowaxanthone B	Bacterial	Infection
Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity .

HY-N10678

R-30-Hydroxygambogic acid	Others	Cancer
R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .

HY-N9113

1,3,5,6-Tetrahydroxyxanthone	Others	Cardiovascular Disease
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

HY-N3347R

Macurin (Standard) Maclurin (Standard)	Reference Standards Others	Others
Macurin is a xanthone that can be isolated from Garcinia lancilimba .

HY-N10673

10α-Hydroxyepigambogic acid	Others	Cancer
10α-Hydroxyepigambogic acid can be extracted from Garcinia hanburyi. 10α-Hydroxyepigambogic acid can be used in the research of tumors .

HY-107569R

Garcinol (Standard)	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite Reference Standards	Inflammation/Immunology Cancer
Garcinol (Standard) is the analytical standard of Garcinol. This product is intended for research and analytical applications. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N3637

Cotoin	Others	Metabolic Disease
Cotoin is a natural product isolated from the stem bark of Garcinia virgate .

HY-124537

(+)-Volkensiflavone	Others	Others
(+)-Volkensiflavone is a biflavonoid, that can be isolated from the fruits of Garcinia livingstonei (Clusiaceae) .

HY-N1868

3-Prenyl-2,4,6-trihydroxybenzophenone	Others	Others
3-Prenyl-2,4,6-trihydroxybenzophenone is a Xanthones product that can be isolated from the herbs of Garcinia cowa .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard) Garcinia lactone (Standard)	Reference Standards ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-N8557

1,5-Dihydroxyxanthone	Others	Others
1,5-Dihydroxyxanthone (Compound 5) is a xanthone that can be isolated from the root of Garcinia cowa .

HY-N1647

2',3',6-Trihydroxy-2,4-dimethoxybenzophenone	Others	Others
2',3',6-Trihydroxy-2,4-dimethoxybenzophenone (compound 1) is a benzophenone derivative, that can be isolated from the herbs of Garcinia xanthochymus .

HY-N8475

6-Deoxyisojacareubin	PKC	Cancer
6-Deoxyisojacareubin is a PKC inhibitor that inhibits the proliferation of QGY-7703 cells in a concentration-dependent manner. 6-Deoxyisojacareubin is also a natural product that can be obtained from Garcinia nervosa. 6-Deoxyisojacareubin can be used in cancer research .

HY-N8876

Paucinervin A	Others	Cancer
Paucinervin A (Compound 1) is a type of bittern. Paucinervin A inhibits the growth of HeLa cells (IC₅₀=29.5 μM). Paucinervin A is isolated from the natural Garcinia paucinervis .

HY-N10676

8,8a-Dihydro-8-hydroxygambogic acid	Others	Cancer
8,8a-Dihydro-8-hydroxygambogic acid is a natural product, that can be isolated from the resin of Garcinia hanburyi. 8,8a-Dihydro-8-hydroxygambogic acid shows anticancer activity .

HY-N8338

Pancixanthone A	Parasite	Infection
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Parasite	Infection
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N0985

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Cancer
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone is a xanthone that can be isolated from Garcinia xanthochymus. 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone shows moderate cytotoxicities against MDA-MB-435S and A549 cell lines with IC₅₀s of 1.3 and 3.86 μg/ml, respectively .

HY-N0986

1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone	Others	Cancer
1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone is a nature product that could be isolated from the stem barks of Garcinia xanthochymus. 1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone has antiproliferative active. 1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone can be used in research of cancer .

HY-N9045

7-Prenyljacareubin	Others	Others
7-Prenyljacareubin is a natural xanthone found in Garcinia gardneriana .

HY-N6247

Fuscaxanthone C	Others	Others
Fuscaxanthone C is an xanthone isolated from the stem bark of Garcinia fusca .

HY-N10398

Garcinielliptone HD	Others	Others
Garcinielliptone HD is a compound isolated from the heartwood of Garcinia subelliptica Merr. .

HY-N8878

Latisxanthone C	Others	Others
Latisxanthone C (compound 15) is a pyranoxanthonethat can be found in Garcinia species .

HY-N3189

Nigrolineaxanthone V	Others	Others
Nigrolineaxanthone V is a Xanthones product that can be isolated from the fruits of Garcinia mangostana L. .

HY-N9152

Parvifolixanthone B	Others	Others
Parvifolixanthone B is a Xanthones product that can be isolated from the twigs of Garcinia parvifolia. .

HY-N1197

Subelliptenone G 1,4,5-Trihydroxyxanthone	Others	Others
Subelliptenone G is a simple oxygenated xanthone that can be isolated from the root bark of Garcinia subelliptica .

HY-N8891

1,2,5-Trihydroxyxanthone	Others	Others
1,2,5-Trihydroxyxanthone is a Xanthones product that can be isolated from the barks of Garcinia tetralata. .

HY-N9219

2,5-Dihydroxyxanthone	Others	Others
2,5-Dihydroxyxanthone is a Xanthones product that can be isolated from the stem barks of Garcinia tetrandra .

HY-137949

Formoxanthone A	Apoptosis	Cancer
Formoxanthone A is an apoptosis inducing compound that can significantly reduce the viability of HeLa cells at 25 μM .

HY-N4094R

Morellic acid (Standard)	Reference Standards Others	Inflammation/Immunology
Morellic acid (Standard) is the analytical standard of Morellic acid. This product is intended for research and analytical applications. Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .

HY-N3324

Mangostanol (+)-Mangostanol	Phosphodiesterase (PDE)	Others
Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE) .

HY-N3482

Isogarciniaxanthone E	Others	Neurological Disease
Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth .

HY-N1000

1,7-Dihydroxy-3-methoxy-2-prenylxanthone	Others	Others
1,7-Dihydroxy-3-methoxy-2-prenylxanthone is a Xanthones product that can be isolated from the fruits of Garcinia mangostana .

HY-N4292

3,8-Dihydroxy-2,4,6-trimethoxyxanthone	Others	Others
3,8-Dihydroxy-2,4,6-trimethoxyxanthone is a trimethoxyxanthone, a natural product, can be isolated from the stems of Garcinia multiflora .

HY-N8857

Parvifolixanthone A	Reactive Oxygen Species (ROS)	Others
Parvifolixanthone A is a xanthone compound that can be isolated from Garcinia parvifolia. Parvifolixanthone A exhibits antioxidant activity with IC₅₀ of submicromolar level (0.18–0.38 μM) .

HY-N0991

1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone	Others	Others
1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone is a natural product that can be isolated from the herbs of Garcinia mangostana .

HY-N3974

Griffipavixanthone (+)-Griffipavixanthone	Apoptosis	Cancer
Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC₅₀: 4.58 mM) .

HY-N12436

11α-O-Tigloyl-12β-O-acetyltenacigenin B	Aurora Kinase	Cancer
11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester derivative of Tenacigenin B (HY-N1168), which is isolated from Garcinia cambogia (MTC). Tenacigenin B modulates the antitumor effects of Aurora-A in lymphoma.

HY-N8362

1-Isomangostin	Lipase	Metabolic Disease
1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N9892

Guttiferone G	Sirtuin	Others
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC₅₀: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC₅₀: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .

製品番号	製品名	Type

HY-W338584

Hydroxycitric acid tripotassium

1 Publications Verification

生化学アッセイ試薬

Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .

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