1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
  3. (-)-Hydroxycitric acid lactone

(-)-Hydroxycitric acid lactone (Synonyms: Garcinia lactone)

Cat. No.: HY-N7347
Handling Instructions

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.

For research use only. We do not sell to patients.

(-)-Hydroxycitric acid lactone Chemical Structure

(-)-Hydroxycitric acid lactone Chemical Structure

CAS No. : 27750-13-6

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Description

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].

In Vivo

(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken[2].

Animal Model: 1-day-old male broiler chickens[2]
Dosage: 1000, 2000, 3000 mg/kg
Administration: Fed for a period of 4 weeks
Result: Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.
Molecular Weight

190.11

Formula

C₆H₆O₇

CAS No.

27750-13-6

SMILES

O[[email protected]](CC(O1)=O)(C(O)=O)[[email protected]]1C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(-)-Hydroxycitric acid lactoneGarcinia lactoneATP Citrate LyaseACLYderivativeHIFweight-controllingagentfatsynthesisfoodintakeInhibitorinhibitorinhibit

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(-)-Hydroxycitric acid lactone
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