1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
  3. (-)-Hydroxycitric acid lactone

(-)-Hydroxycitric acid lactone  (Synonyms: Garcinia lactone)

Cat. No.: HY-N7347 Purity: ≥97.0%
COA Handling Instructions

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.

For research use only. We do not sell to patients.

(-)-Hydroxycitric acid lactone Chemical Structure

(-)-Hydroxycitric acid lactone Chemical Structure

CAS No. : 27750-13-6

Size Price Stock Quantity
5 mg USD 220 In-stock
10 mg USD 380 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].

In Vivo

(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1-day-old male broiler chickens[2]
Dosage: 1000, 2000, 3000 mg/kg
Administration: Fed for a period of 4 weeks
Result: Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.
Molecular Weight

190.11

Appearance

Solid

Formula

C6H6O7

CAS No.
SMILES

O[[email protected]](CC(O1)=O)(C(O)=O)[[email protected]]1C(O)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1315.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2601 mL 26.3006 mL 52.6011 mL
5 mM 1.0520 mL 5.2601 mL 10.5202 mL
10 mM 0.5260 mL 2.6301 mL 5.2601 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(-)-Hydroxycitric acid lactone
Cat. No.:
HY-N7347
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