(-)-Hydroxycitric acid lactone (Synonyms: Garcinia lactone)

Name: (-)-Hydroxycitric acid lactone
Brand: MedChemExpress
SKU: HY-N7347
Rating: 4.5 (1 reviews)

Cat. No.: HY-N7347 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.

For research use only. We do not sell to patients.

(-)-Hydroxycitric acid lactone Chemical Structure

CAS No. : 27750-13-6

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

In Vivo

(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1-day-old male broiler chickens^[2]
Dosage:	1000, 2000, 3000 mg/kg
Administration:	Fed for a period of 4 weeks
Result:	Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.

Molecular Weight

190.11

Formula

C₆H₆O₇

CAS No.

27750-13-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@](CC(O1)=O)(C(O)=O)[C@H]1C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1315.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2601 mL	26.3006 mL	52.6011 mL
5 mM	1.0520 mL	5.2601 mL	10.5202 mL
10 mM	0.5260 mL	2.6301 mL	5.2601 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (10.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (278 KB) SDS (392 KB)

COA (256 KB) HNMR (269 KB) MS (187 KB)

Handling Instructions (2659 KB)

References

[1]. Jena BS, et al. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50(1):10-22. [Content Brief]

[2]. Han J, et al. (-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related geneexpression in broiler chickens. Lipids Health Dis. 2016 Feb 24;15:37. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2601 mL	26.3006 mL	52.6011 mL	131.5028 mL
	5 mM	1.0520 mL	5.2601 mL	10.5202 mL	26.3006 mL
	10 mM	0.5260 mL	2.6301 mL	5.2601 mL	13.1503 mL
	15 mM	0.3507 mL	1.7534 mL	3.5067 mL	8.7669 mL
	20 mM	0.2630 mL	1.3150 mL	2.6301 mL	6.5751 mL
	25 mM	0.2104 mL	1.0520 mL	2.1040 mL	5.2601 mL
	30 mM	0.1753 mL	0.8767 mL	1.7534 mL	4.3834 mL
	40 mM	0.1315 mL	0.6575 mL	1.3150 mL	3.2876 mL
	50 mM	0.1052 mL	0.5260 mL	1.0520 mL	2.6301 mL
	60 mM	0.0877 mL	0.4383 mL	0.8767 mL	2.1917 mL
	80 mM	0.0658 mL	0.3288 mL	0.6575 mL	1.6438 mL
	100 mM	0.0526 mL	0.2630 mL	0.5260 mL	1.3150 mL

(-)-Hydroxycitric acid lactone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Hydroxycitric acid lactone27750-13-6Garcinia lactoneATP Citrate LyaseACLYderivativeHIFweight-controllingagentfatsynthesisfoodintakeInhibitorinhibitorinhibit

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(-)-Hydroxycitric acid lactone (Synonyms: Garcinia lactone)

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(-)-Hydroxycitric acid lactone Related Antibodies

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Complete Stock Solution Preparation Table

(-)-Hydroxycitric acid lactone Related Classifications

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