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Results for "

LNCaP+cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) AMPK (1) Androgen Receptor (10) Apoptosis (11) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Caspase (1) EGFR (1) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) Ferroptosis (1) Histone Demethylase (4) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (1) LYTACs (2) Monoamine Oxidase (3) mTOR (1) NF-κB (1) PARP (1) PD-1/PD-L1 (1) PI3K (1) PKC (2) PROTACs (1) PSMA (3) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Ser/Thr Protease (1) TNF Receptor (1)
By Research Areas:	Cancer (25) Endocrinology (1) Infection (4) Inflammation/Immunology (4)

By Targets:

5 alpha Reductase (2)

AMPK (1)

Androgen Receptor (10)

Apoptosis (11)

Autophagy (1)

Bacterial (2)

Bcl-2 Family (1)

Caspase (1)

EGFR (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Epigenetic Reader Domain (1)

Ferroptosis (1)

Histone Demethylase (4)

Isotope-Labeled Compounds (1)

Ligands for Target Protein for PROTAC (1)

LYTACs (2)

Monoamine Oxidase (3)

mTOR (1)

NF-κB (1)

PARP (1)

PD-1/PD-L1 (1)

PI3K (1)

PKC (2)

PROTACs (1)

PSMA (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

Ser/Thr Protease (1)

TNF Receptor (1)

By Research Areas:

Cancer (25)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-113332

Myristoleic acid 1 Publications Verification	Environmental Pollutants Endogenous Metabolite Apoptosis	Inflammation/Immunology
Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells .

HY-130992

Androgen receptor antagonist 1	Androgen Receptor Ligands for Target Protein for PROTAC	Cancer
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC₅₀ of 59 nM . Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively .

HY-13626

Spisulosine ES-285	PKC Apoptosis	Cancer
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-115282A

JNJ-63576253 1 Publications Verification TRC-253	Androgen Receptor	Cancer
JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC₅₀s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) .

HY-170329

PROTAC AR Degrader-8	PROTACs Androgen Receptor Apoptosis	Cancer
PROTAC AR Degrader-8 is the PROTAC degrader for androgen receptor (AR) that degrades AR-FL with DC₅₀s of 0.018 μM and 0.14 μM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC₅₀ of 0.026 μM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC₅₀ values of 0.038 μM and 1.11 μM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model. PROTAC AR Degrader-8 can be used for the research of prostate cancer, castration-resistant prostate cancer .

HY-N7510

12-O-Methylcarnosic acid 12-Methoxycarnosic acid	5 alpha Reductase	Infection Cancer
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .

HY-N16483

Procyanidin B2-3'-O-gallate	Apoptosis Caspase Bcl-2 Family PARP Androgen Receptor	Cancer
Procyanidin B2-3'-O-gallate is a mono-gallate ester that can be isolated from grape seed extract. Procyanidin B2-3'-O-gallate has anti-cancer efficacy and reduces the viability of prostate carcinoma LNCaP cells. Furthermore, Procyanidin B2-3'-O-gallate induces apoptosis, and causes caspases-9 and -3 and PARP cleavage, and down-regulates Bcl-2, Bcl-Xl and androgen receptor levels .

HY-N16066

Candidusin A CHNQD-0803	AMPK Apoptosis NF-κB TNF Receptor	Inflammation/Immunology
Candidusin A (CHNQD-0803) (Compound 4) is a AMPK activator with a K_D of 47.28 nM. Candidusin A can be isolated from marine fungus Aspergillus candidus. Candidusin A has cytotoxic activity and induces apoptosis in human prostate cancer cells (22Rv1, PC-3 and LNCaP cells). Candidusin A reduces adipogenesis genes expression and fat deposition, negatively regulates the NF-κB-TNFα inflammatory axis to suppress inflammation, and ameliorates liver injury and fibrosis. Candidusin A can be used for non-alcoholic steatohepatitis (NASH) research .

HY-N1342

Rocaglaol	Apoptosis	Cancer
Rocaglaol induces apoptosis and cell cycle arrest in LNCaP cells .

HY-175248

PSMA-DIM	PSMA	Cancer
PSMA-DIM is a dimeric PSMA ligand with a K_d of 37.09 nM for LNCaP cells. PSMA-DIM can be radiolabeled with [ ⁶⁸Ga]Ga to form [ ⁶⁸Ga]Ga-PSMA-DIM. [ ⁶⁸Ga]Ga-PSMA-DIM can effectively distinguish between cells and animal models with different expression levels of PSMA. [ ⁶⁸Ga]Ga-PSMA-DIM exhibits high LNCaP cells uptake and tumor uptake peak values. PSMA-DIM can be used for the study of prostate cancer (PCa) .

HY-124585

Y08060	Epigenetic Reader Domain	Cancer
Y08060 is a selective BET inhibitor. Y08060 inhibits the viability of C4-2B and LNCaP cell lines with IC₅₀ values of 3.23 and 4.41 μM. Y08060 can suppress colony formation as well as AR expression in prostate cancer cell line. Y08060 can be studied in prostate cancer research .

HY-N8504

Neoaureothin NSC 260179; Spectinabilin	Bacterial	Infection
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC₅₀=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC₅₀=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC₅₀s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.

HY-13626S

Spisulosine-d3 ES-285-d₃	Isotope-Labeled Compounds PKC Apoptosis	Cancer
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-131953

Androgen receptor-IN-3	Androgen Receptor	Cancer
Androgen receptor-IN-3 (Compound 22) is an androgen receptor inhibitor. Androgen receptor-IN-3 inhibits AR-driven transcriptional activity in LNCaP cells, with an IC₅₀ of 5.04 μM .

HY-N8856

Angelol M	Others	Others
Angelol M,isolated from the roots of Angelica gigas Nakai, shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells .

HY-113332R

Myristoleic acid (Standard)	Reference Standards Apoptosis Endogenous Metabolite	Inflammation/Immunology
Myristoleic acid (Standard) is the analytical standard of Myristoleic acid. This product is intended for research and analytical applications. Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells[1].

HY-176160

Jacaric acid methyl ester Methyl jacarate; SFE 19:3	Apoptosis	Cancer
Jacaric acid methyl ester is a methyl ester form of the conjugated PUFA jacaric acid. Jacaric acid can induce apoptosis selectively in human prostate cancer cells. Jacaric acid induces concentration- and time-dependent LNCaP cell death. Jacaric acid methyl ester can be studied in anticancer research .

HY-153772

Androgen receptor antagonist 8	Androgen Receptor	Cancer
Androgen receptor antagonist 8 (Example 13) is an androgen receptor antagonist. Androgen receptor antagonist 8 inhibits prostate specific antigen secretion in LNcap cell (IC₅₀: 88 nM). Androgen receptor antagonist 8 can be used for prostate cancer research .

HY-144755

MC2652	Histone Demethylase	Cancer
MC2652 (compound 1a) is a potent LSD1 inhibitor. MC2652 displays high inhibiting effects in MV4-11 and NB4 leukaemia cells. MC2652 shows antiproliferative activity against prostate cancer LNCaP cells .

HY-164662

mTOR inhibitor-24	mTOR PI3K	Cancer
mTOR inhibitor-24 (comounp 9d) is a mTOR inhibitor, with IC₅₀s of 0.34 nM (mTOR) and 324 nM (PI3K-α) respectively. mTOR inhibitor-24 inhibtis LNCaP cell proliferation (IC₅₀: 180 nM) .

HY-139970

VPC-13789	Androgen Receptor	Endocrinology Cancer
VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC₅₀=0.19 μM) .

HY-115282

JNJ-63576253 free base TRC-253 free base	Androgen Receptor	Cancer
JNJ-63576253 (TRC-253) free base is a potent and orally active full antagonist of androgen receptor (AR), with IC₅₀s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 free base can be used for the research of castration-resistant prostate cancer (CRPC) .

HY-N2733

7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin	Others	Others
7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin is a coumarin, that can be isolated from campylotropis hirtella (FRANCH.) SCHINDL. 7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin inhibits PSA secretion in LNCaP cells, with an IC₅₀ of 24.2 μg/mL .

HY-W012088

(Z)-Methyl tetradec-9-enoate Myristoleic acid methyl ester; Methyl myristoleate; cis-9-Tetradecenoate methyl ester	Bacterial Apoptosis	Infection
(Z)-Methyl tetradec-9-enoate (Myristoleic acid methyl ester; Methyl myristoleate) is a cytotoxic component extracted from S. repens fruit extract. It induces apoptosis and necrosis in human prostate cancer LNCaP cells. In addition, (Z)-Methyl tetradec-9-enoate found in cheese-making byproducts inhibits Candida albicans germination with a minimum inhibitory concentration (MIC) of 9 μM in vivo.

HY-144758

LSD1-IN-17	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 17.2 μM .

HY-179050

Androgen receptor-IN-7	Androgen Receptor Reactive Oxygen Species (ROS)	Cancer
Androgen receptor-IN-7 is a potent androgen receptor (AR) inhibitor. Androgen receptor-IN-7 exhibits potent anticancer activity against PC-3 cells (IC₅₀ =370.37 nM) and LNCaP cells via both AR-dependent and AR-independent pathways. Androgen receptor-IN-7 induces ROS production in PC-3 cells. Androgen receptor-IN-7 can be used for prostate cancer research .

HY-144756

LSD1-IN-15	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-15 (compound 1b) is a potent LSD1 inhibitor. LSD1-IN-15 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.149, 0.028, and 0.327 μM, respectively. LSD1-IN-15 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 9.9 μM .

HY-144757

LSD1-IN-16	Histone Demethylase Monoamine Oxidase	Cancer
LSD1-IN-16 (compound 4b) is a potent LSD1 inhibitor. LSD1-IN-16 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC₅₀ values of 0.015, 0.024, and 0.366 μM, respectively. LSD1-IN-16 displays cell growth arrest in prostate cancer LNCaP cells, with an IC₅₀ of 15.2 μM .

HY-158775

Ferroptocide	Ferroptosis Apoptosis Autophagy	Cancer
Ferroptocide is a cell death inducer that triggers ferroptosis and has anti-tumor activity. Ferroptocide can induce oxidative stress, leading to G2/M cell cycle arrest and apoptosis activation in LNCaP cells, while also effectively inhibiting the cell viability of both LNCaP and TRAMP-C1 cells. Ferroptocide can be used to study its capability to induce mitochondrial autophagy and to trigger immunogenic cell death (ICD) in prostate cancer cells .

HY-173409

AR antagonist 11	Androgen Receptor Ser/Thr Protease	Inflammation/Immunology
AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC₅₀ of 0.019 μM. AR antagonist 11 is also effective against AR ^F877L/T878A mutant (IC₅₀: 1.03 μM). AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC₅₀: 0.54 μM). AR antagonist 11 can be used for research of prostate cancer (PCa) .

HY-N7510R

12-O-Methylcarnosic acid (Standard) 12-Methoxycarnosic acid (Standard)	Reference Standards 5 alpha Reductase	Infection Cancer
12-O-Methylcarnosic acid (Standard) is the analytical standard of 12-O-Methylcarnosic acid. This product is intended for research and analytical applications. 12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC₅₀ value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .

HY-181830

Atz-L5	PD-1/PD-L1 PSMA LYTACs	Cancer
Atz-L5 is a PD-L1 PTAC (PSMA-targeted chimera) degrader (DC₅₀: 18 pM in PC3-PIP cells; 2 pM in LNCaP cells) and LYTAC. Atz-L5 promotes lysosomal degradation of PD-L1 in PSMA-positive prostate cancer cells. Atz-L5 is applicable to the research of prostate cancer .

HY-181829

Ctx-L3	EGFR PSMA LYTACs	Cancer
Ctx-L3 is a selective EGFR PTAC (PSMA-targeted chimera) degrader (DC₅₀: 4.3 pM in LNCaP cells) and LYTAC. Ctx-L3 recruits prostate-specific membrane antigen (PSMA) and mediates lysosomal degradation of EGFR in PSMA-positive prostate cancer cells. Ctx-L3 exhibits degrading activity against EGFR in prostate cancer cells. Ctx-L3 is applicable to related research on prostate cancer .

Art. -Nr.	Produktname	Category	Target	Chemical Structure