1. Apoptosis
  2. Apoptosis
  3. Myristoleic acid

Myristoleic acid 

Cat. No.: HY-113332
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Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells.

For research use only. We do not sell to patients.

Myristoleic acid Chemical Structure

Myristoleic acid Chemical Structure

CAS No. : 544-64-9

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Description

Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells[1].

In Vitro

Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells[1].
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation[2].

Cell Proliferation Assay[1]

Cell Line: Human prostatic carcinoma LNCaP cells.
Concentration: 0, 50, 100, 150, 200, 250 μg/mL.
Incubation Time: 24 h.
Result: When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively.
In Vivo

Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice[2].

Animal Model: C57BL/6 mice at 5 weeks[2].
Dosage: 0.2, 2 mg/kg
Administration: IP every 24 h for 4 days.
Result: Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner.
Molecular Weight

226.36

Formula

C₁₄H₂₆O₂

CAS No.

544-64-9

SMILES

CCCC/C=C\CCCCCCCC(O)=O

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Storage

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Keywords:

Myristoleic acidApoptosisnecrosisInhibitorinhibitorinhibit

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Myristoleic acid
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