Androgen receptor-IN-7
Androgen receptor-IN-7 is a potent androgen receptor (AR) inhibitor. Androgen receptor-IN-7 exhibits potent anticancer activity against PC-3 cells (IC50 =370.37 nM) and LNCaP cells via both AR-dependent and AR-independent pathways. Androgen receptor-IN-7 induces ROS production in PC-3 cells. Androgen receptor-IN-7 can be used for prostate cancer research.
For research use only. We do not sell to patients.
- CAS No.: 401580-43-6
- Formula: C14H9FN2O
- Molecular Weight:240.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human DU145 cells after 24 hrs by MTT assay
Anticancer activity against human DU145 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| HCT-116 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human HCT116 cells after 24 hrs by MTT assay
Anticancer activity against human HCT116 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| LNCaP | IC50 |
23.7 μM
Compound: 3a
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Anticancer activity against human LNCAP cells after 24 hrs by MTT assay
Anticancer activity against human LNCAP cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| MCF7 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human MCF7 cells after 24 hrs by MTT assay
Anticancer activity against human MCF7 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| MDA-MB-231 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human MDA231 cells after 24 hrs by MTT assay
Anticancer activity against human MDA231 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| MIA PaCa-2 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human MIAPaCa2 cells after 24 hrs by MTT assay
Anticancer activity against human MIAPaCa2 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
| PC-3 | IC50 |
>1 x 10-3μM
Compound: 3a
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Anticancer activity against human PC3 cells after 24 hrs by MTT assay
Anticancer activity against human PC3 cells after 24 hrs by MTT assay
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[PMID: 19376704] |
Androgen receptor-IN-7 (MS14) (0-300 nM, 24 h) induces a dose-dependent increase of ROS levels in PC-3 cells, resulting in an increase in relative ROS levels of 19.8% at 150 nM and 49% at 300 nM compared to the control[1].
Androgen receptor-IN-7 (150-300 nM, 24 h) reduces androgen receptor expression in PC-3 cells in a dose-dependent manner[1].
Androgen receptor-IN-7 strongly binds to the androgen receptor pocket, stabilized by key hydrogen bond interactions with Arg752 and Gln711[1].
Androgen receptor-IN-7 (0-1000 nM, 24 h) exhibits dose-dependent antiproliferative effects in LNCaP cells (achieving 78.2 % inhibition at 1000 nM), indicating that it retains significant activity in an AR-positive model, acting through both AR-dependent and AR-independent pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3 cells
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Concentration:150 and 300 nM
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Incubation Time:24 h
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Result:Resulted in a dose-dependent decrease in androgen receptor expression compared to the control group.
Chemical Information
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CAS No. 401580-43-6
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Molecular Weight 240.23
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Formula C14H9FN2O
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SMILES
FC1=CC=C(C=C1)C2=NC(C3=CC=CC=C3)=NO2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Androgen receptor-IN-7 Related Classifications
HY-179050 Related Classifications
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