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Mitochondria probe

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Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1055
    MitoSOX Red
    Maximum Cited Publications
    263 Publications Verification

    		 Fluorescent Dye Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red.
    Excitation/emission wavelength: 510/580 nm.
    MitoSOX Red
  • HY-15534
    JC-1
    210+ Cited Publications

    CBIC2

    		 Fluorescent Dye Others
    JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
    JC-1
  • HY-D0985A
    TMRE
    70+ Cited Publications

    Tetramethylrhodamine ethyl ester perchlorate

    		 Fluorescent Dye Others
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    TMRE
  • HY-D0984A
    TMRM Perchlorate
    30+ Cited Publications

    T668

    		 Fluorescent Dye Others
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    TMRM Perchlorate
  • HY-D0816
    Rhodamine 123
    25+ Cited Publications

    RH-123; R-22420

    		 Fluorescent Dye Cardiovascular Disease
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Rhodamine 123
  • HY-D1063
    IR-780
    5+ Cited Publications

    		 Fluorescent Dye Apoptosis Reactive Oxygen Species (ROS) Cancer
    IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .
    IR-780
  • HY-D0309
    Rhodamine 6G
    4 Publications Verification

    Basic Red 1

    		 Environmental Pollutants Fluorescent Dye Cancer
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Rhodamine 6G
  • HY-125623
    MitoPerOx
    3 Publications Verification

    		 Fluorescent Dye Others
    MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].
    MitoPerOx
  • HY-W111141
    BCN-OH

    endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

    		 Biochemical Assay Reagents Others
    BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is an alcohol functionalized cyclooctyne derivative. BCN-OH can act as a raw material for synthesizing other probes (such as BCN-TPP). BCN-OH is used to construct targeted probes by coupling with carboxyl-containing compounds (such as TPP-COOH). BCN-OH can be used as control reagent for BCN-TPP .
    BCN-OH
  • HY-N16308
    ER-Laurdan

    		Fluorescent Dye Others
    ER-Laurdan is a derivative of the membrane-permeable fluorescent probe Laurdan (HY-D0080) that targets the endoplasmic reticulum (ER). As a membrane fluidity reporter, ER-Laurdan specifically localizes to the ER luminal membrane, and exhibits a prominent solvatochromic response to fluidity changes caused by membrane packing and exogenous saturated fatty acid stress. ER-Laurdan shows no overlapping localization with mitochondria, enables quantitative analysis of ER membrane fluidity via generalized polarization ratio measurement, and allows automatic signal masking with the help of ER markers. With high specificity and quantitative capability, ER-Laurdan serves as an important tool for investigating metabolic disorders and associated changes in the physical properties of cell membranes .
    ER-Laurdan
  • HY-D0984
    TMRM

    		Fluorescent Dye Inflammation/Immunology
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    TMRM
  • HY-DY1003
    JC-1 (solution)

    		Fluorescent Dye Others
    JC-1 (CBIC2) (solution) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm) ; When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
    Solvent and concentration: DMSO: 1.5 mM
    JC-1 (solution)
  • HY-D2295
    Mito-FerroGreen
    5 Publications Verification

    		 Fluorescent Dye Others
    Mito-FerroGreen is a mitochondria-specific ferrous ion detection probe with an excitation wavelength of 488nm .
    Mito-FerroGreen
  • HY-DY1042
    TMRM Perchlorate (solution)

    		Fluorescent Dye Others
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Solvent and concentration: DMSO: 10 mM
    TMRM Perchlorate (solution)
  • HY-DY1073
    MitoPerOx (solution)

    		Fluorescent Dye Others
    MitoPerOx (solution) is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state) , and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction) .
    Solvent and concentration: DMSO: 2 mM
    MitoPerOx (solution)
  • HY-101876
    Rhodamine 800

    		Fluorescent Dye Others
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Rhodamine 800
  • HY-126220
    KMG-301AM

    		Fluorescent Dye Others
    KMG-301AM is the acetoxy methyl esterified form of KMG-301. KMG-301AM successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM
  • HY-DY1023
    TMRE (solution)

    		Fluorescent Dye Others
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Solvent and concentration: DMSO: 10 mM
    TMRE (solution)
  • HY-126220A
    KMG-301AM TFA

    		Fluorescent Dye Others
    KMG-301AM TFA is the acetoxy methyl esterified form of KMG-301. KMG-301AM TFA successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM TFA
  • HY-126474
    MitoB bromide

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .
    MitoB bromide
  • HY-D1158
    HKOCl-4m

    		Fluorescent Dye Inflammation/Immunology
    HKOCl-4m is a selective and mitochondria-targeting rhodol-based fluorescent probe for monitoring mitochondrial hypochlorous acid (HOCl) .
    HKOCl-4m
  • HY-157036
    INSA

    		Fluorescent Dye Others
    INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences .
    INSA
  • HY-DY1054
    Rhodamine 123 (solution)

    		Fluorescent Dye Cardiovascular Disease
    Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Solvent and concentration: DMSO: 5 mM
    Rhodamine 123 (solution)
  • HY-D1156A
    HKSOX-1m (5/6-mixture) hydrobromide
    2 Publications Verification

    		 Reactive Oxygen Species (ROS) Fluorescent Dye Others
    HKSOX-1m (5/6-mixture) hydrobromide is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
    HKSOX-1m (5/6-mixture) hydrobromide
  • HY-D2479
    DMANI

    		Fluorescent Dye Metabolic Disease
    DMANI is an intramolecular charge transfer (ICT)-based mitochondria-targeted ratiometric fluorescent probe. DMANI can monitor mitochondrial peroxynitrite (ONOO −) in living cells .
    DMANI
  • HY-D0309R
    Rhodamine 6G (Standard)

    Basic Red 1 (Standard)

    		 Fluorescent Dye Reference Standards Cancer
    Rhodamine 6G (Standard) is the analytical standard of Rhodamine 6G. This product is intended for research and analytical applications. Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms .
    Rhodamine 6G (Standard)
  • HY-169838
    WYneC

    		Biochemical Assay Reagents Others
    WYneC can specifically bind to sulfinylated proteins in living cells and then react with fluorescent probes containing azide groups for detection. In the field of redox biology, WYneC can also be used to determine the occupancy of S-sulfinylation sites or as a carrier to deliver substances to mitochondria .
    WYneC
  • HY-123583
    MitoBADY

    		Fluorescent Dye Others
    MitoBADY is a mitochondria-selective Raman probe that successfully visualizes mitochondria in live HeLa cells at a concentration of 200-400 nM for 10 minutes. MitoBADY can be utilized for the study of mitochondrial dynamics .
    MitoBADY
  • HY-141646
    MIT-PZR

    		Fluorescent Dye Others
    MIT-PZR is a mitochondria-targeted,? low cytotoxicity fluorescent probe that can be used in live cells and in vivo imaging. Ex / Em = 485 / 705 nm
    MIT-PZR
  • HY-D1156
    HKSOX-1m (5/6-mixture)

    		Reactive Oxygen Species (ROS) Fluorescent Dye Others
    HKSOX-1m (5/6-mixture) is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
    HKSOX-1m (5/6-mixture)
  • HY-172342
    MitoA bromide

    		Fluorescent Dye Cardiovascular Disease
    MitoA (bromide) is a mitochondria-targeted H2S probe, which can be used to assess relative changes in mitochondrial levels of H2S in vivo. MitoA (bromide) can accumulate inside mitochondria within tissues in vivo due to tryphenylphosphonium (TPP) cation. MitoA (bromide) can be studied in research on myocardial ischemia .
    MitoA bromide
  • HY-D2215
    Mito-CCY

    		Fluorescent Dye Cancer
    Mito-CCY is a mitochondria-targeted, NIR-absorbing cryptocyanine probe. Mito-CCY displays a high photothermal conversion efficiency, good biological compatibility in vitro, and photoinduced cytotoxicity in HeLa cells .
    Mito-CCY
  • HY-126474S
    MitoB-d15 bromide

    		Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Inflammation/Immunology
    MitoB-d15 (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals .
    MitoB-d15 bromide
  • HY-158918
    4-CF3-TPP-DC

    4-CF3-Triphenylphosphonium-DC

    		 Biochemical Assay Reagents Others
    4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .
    4-CF3-TPP-DC
  • HY-155062
    IR-251

    		Mitochondrial Metabolism Reactive Oxygen Species (ROS) β-catenin Fluorescent Dye PPAR Cancer
    IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis .
    IR-251
  • HY-149203
    MQA-P

    		Fluorescent Dye Others
    MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO - (λem=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λem>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
    MQA-P
  • HY-149203A
    MQA-P TFA

    		Fluorescent Dye Others
    MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO -, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO -, λem=645 nm; and NIR channel at λem>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .
    MQA-P TFA
  • HY-W205529
    RO 16-6491 free base

    		Fluorescent Dye Neurological Disease
    RO 16-6491 Free base is a selective, reversible inhibitor of monoamine oxidase type B (MAO-B), exhibiting high affinity and specificity for binding sites in human frontal cortex mitochondria and platelet membranes. RO 16-6491 demonstrates a fast dissociation of bound radioactivity at 20 degrees C, indicating its dynamic binding properties. RO 16-6491 also acts as a substrate for MAO-B, suggesting that its oxidation may produce a stable intermediate responsible for its potent inhibitory effects. RO 16-6491 serves as an excellent radioligand probe for investigating the regional tissue distribution of MAO-B in various physiological and pathological states.
    RO 16-6491 free base
  • HY-D3381
    MitoCLox

    		Fluorescent Dye Others
    MitoCLox is a mitochondria-targeted ratiometric fluorescent probe for measuring mitochondrial inner membrane lipid peroxidation .
    MitoCLox
  • HY-D3269
    Mito-Cu(II)

    		Fluorescent Dye Others
    Mito-Cu (II) is a mitochondria-targeted fluorescent probe (Ex/Em = 370/450 nM). Mito-Cu (II) specifically accumulates in mitochondria of living cells and enables real-time detection of exogenous Cu 2+ within mitochondria of living cells. Mito-Cu (II) achieves "on-off-on" fluorescence switching through sequential exposure to Cu 2+ and ethylenediaminetetraacetic acid (EDTA) (HY-Y0682). Its fluorescence is quenched after forming a 1:1 complex with Cu 2+, and the fluorescence recovers when Cu 2+ is chelated by EDTA .
    Mito-Cu(II)
  • HY-D2985
    MI-BP-CC

    		Mitochondrial Metabolism Fluorescent Dye Others
    MI-BP-CC is a mitochondrial-targeting near-infrared fluorescent probe. MI-BP-CC can specifically localize in the mitochondria of living cells. MI-BP-CC visualizes viscosity with an emission wavelength of 722 nm for detecting mitochondrial viscosity .
    MI-BP-CC
  • HY-D2958
    ZP1BG

    		Fluorescent Dye Others
    ZP1BG is a SNAP tag fluorescent probe for detecting Zn 2+, which is formed by the covalent connection of the zinc sensor ZP1 from the Zinpyr family with the benzyl guanine group. ZP1BG can be used to detect the concentration of Zn 2+ in neuronal organelles such as the Golgi apparatus and mitochondria .
    ZP1BG
  • HY-D3166
    CEMT

    		Fluorescent Dye Others
    CEMT is a carboxylesterase (CE) substrate and a ratiometric two-photon fluorescent reporter probe. CEMT can be hydrolyzed by CE to generate HMT, which is used for mitochondrial pH sensing. After activation by CE, CEMT exhibits ratiometric fluorescence changes in response to pH variations. CEMT targets and covalently binds to mitochondria, and can avoid leakage during acidification, thus enabling in situ imaging .
    CEMT
  • HY-D3255
    CTAP-1

    		Fluorescent Dye Others
    CTAP-1 is a monovalent copper ion probe. CTAP-1 binds to monovalent copper Cu (I) to inhibit photoinduced electron transfer, thereby enhancing fluorescence emission. CTAP-1 produces copper-dependent perinuclear staining that colocalizes with mitochondria and the Golgi apparatus. CTAP-1 can be used for imaging Cu (I) pools, excitation/emission Wavelength: 365/480 nm .
    CTAP-1
  • HY-161476
    Ir-ImNO

    		Fluorescent Dye Cancer
    Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy .
    Ir-ImNO
  • HY-D3196
    AG2

    		Fluorescent Dye Cancer
    AG2 is a glucose uptake tracer and two-photon fluorescent probe. AG2 is taken up by cells via glucose-specific transport systems, rather than passive diffusion; it preferentially accumulates in cancer cells and colon cancer tissues compared with normal cells and tissues; it mainly localizes to mitochondria, with a small amount also distributed in the cytoplasm and cell membrane. AG2 can be used for colon cancer research .
    AG2

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