Ir-ImNO

Cat. No.: HY-161476: FAQs
Data Sheet Handling Instructions

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Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy.

For research use only. We do not sell to patients.

Ir-ImNO Chemical Structure

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Description	Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy^[1].
In Vitro	Ir-ImNO (5 μM; 6-48 h) exhibits low cytotoxicity in 4T1 and RAW 264.7 cells, maintaining a cell survival rate of over 80% after 48 hours of incubation^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Ir-ImNO Related Antibodies
Molecular Weight	936.52
Formula	C₄₉H₃₆ClIrN₆
Unlabeled CAS
SMILES	NC1=C(NCC2=CC=CC=C2)C3=CC=C[N]4=C3C5=C1C=CC=[N]5[Ir+3]67([N]8=C9C(C=CC=C9)=CC=C8C%10=CC=CC=[C-]%107)4[N]%11=C%12C(C=CC=C%12)=CC=C%11C%13=CC=CC=[C-]%136.[Cl-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)
References	[1]. Wen Y, et al. A Mitochondria-Targeted Nitric Oxide Probe for Multimodality Imaging of Macrophage Immune Responses. Anal Chem. 2024;96(17):6666-6673. [Content Brief]

Ir-ImNO Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ir-ImNOFluorescent Dye4T1RAW 264.7immune imaging monitoringcell membrane permeabilityNitric Oxide (NO) detectionInhibitorinhibitorinhibit

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Ir-ImNO

Ir-ImNO Related Antibodies

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