2. Metabolic Enzyme/Protease Stem Cell/Wnt Vitamin D Related/Nuclear Receptor NF-κB Cell Cycle/DNA Damage Immunology/Inflammation Others
  3. Fluorescent Dye Reactive Oxygen Species PPAR β-catenin Mitochondrial Metabolism
  4. IR-251

IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis.

For research use only. We do not sell to patients.

IR-251 Chemical Structure

IR-251 Chemical Structure

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IR-251 Related Antibodies

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Description

IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis[1].

Molecular Weight

886.48

Formula

C51H70BrClN4O2
SMILES

CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/CC3N(CCCCCC(O/C(NC4CCCCC4)=N/C5CCCCC5)=O)C(C=CC=C6)=C6C3(C)C)=[N+](CC)C7=C1C=CC=C7.[Br-]
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Room temperature in continental US; may vary elsewhere.
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IR-251 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-251IR251IR 251Fluorescent DyeReactive Oxygen SpeciesPPARβ-cateninMitochondrial MetabolismPeroxisome proliferator-activated receptorsBeta cateninAntiproliferativecancerOATPmitochondrionNIRfluorescent probeInhibitorinhibitorinhibit

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