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Results for "

covalent+linkage

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

3

Fluorescent Dyes

8

Biochemical Assay Reagents

23

Peptides

3

Natural
Products

8

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0671
    Vancomycin
    Maximum Cited Publications
    94 Publications Verification

    		 Bacterial Autophagy Antibiotic Infection Cancer
    Vancomycin is an antibiotic for the treatment of bacterial infections.
    Vancomycin
  • HY-P4153
    Enlicitide chloride

    MK-0616 chloride

    		 PCSK9 Cardiovascular Disease
    Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC50 of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders .
    Enlicitide chloride
  • HY-140678
    mPEG10000-amine

    mPEG10000-NH2

    		 PROTAC Linkers Cancer
    DBCO-PEG10000-Amine (DBCO-PEG10000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
    mPEG10000-amine
  • HY-170704
    DSPE-PEG2000-TCO

    		Liposome Metabolic Disease Cancer
    DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
    DSPE-PEG2000-TCO
  • HY-P2265A
    SAH-SOS1A TFA

    		SOS1 Ras Cancer
    SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .
    SAH-SOS1A TFA
  • HY-P2203
    SAHM1
    1 Publications Verification

    		 Notch Inflammation/Immunology
    SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice .
    SAHM1
  • HY-174935
    DBCO-PEG1000-NHS

    		Biochemical Assay Reagents Others
    DBCO-PEG1000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
    DBCO-PEG1000-NHS
  • HY-P1368
    Stressin I
    1 Publications Verification

    Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)

    		 CRFR Endocrinology
    Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats .
    Stressin I
  • HY-174935A
    DBCO-PEG2000-NHS

    		Biochemical Assay Reagents Others
    DBCO-PEG2000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
    DBCO-PEG2000-NHS
  • HY-174929A
    DBCO-PEG5000-Amine

    DBCO-PEG5000-NH2

    		 Biochemical Assay Reagents Others
    DBCO-PEG5000-Amine (DBCO-PEG5000-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
    DBCO-PEG5000-Amine
  • HY-P1368A
    Stressin I TFA
    1 Publications Verification

    Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA

    		 CRFR Endocrinology
    Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats .
    Stressin I TFA
  • HY-D2744
    BP Fluor 488 TCO

    		Fluorescent Dye Others
    BP Fluor 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M-1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.
    BP Fluor 488 TCO
  • HY-P2265
    SAH-SOS1A

    		SOS1 Ras Cancer
    SAH-SOS1A is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM), directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS .
    SAH-SOS1A
  • HY-P2261
    STAD 2
    1 Publications Verification

    		 PKA Infection
    STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .
    STAD 2
  • HY-P1712A
    Arthrofactin TFA

    		Biochemical Assay Reagents Metabolic Disease
    Arthrofactin (TFA) is an effective lipopeptide biosurfactant in Pseudomonas sp. MIS38. Arthrofactin (TFA) production is associated with multiple ATP dependent active transporter systems .
    Arthrofactin TFA
  • HY-P10964
    Tezusomant

    		GHSR Endocrinology
    Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research on diseases caused by excessive growth hormone secretion, such as acromegaly .
    Tezusomant
  • HY-174935C
    DBCO-PEG5000-NHS

    		Biochemical Assay Reagents Others
    DBCO-PEG5000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
    DBCO-PEG5000-NHS
  • HY-118112
    4-N-Maleimidobenzoicacid-NHS

    		Biochemical Assay Reagents Others
    4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
    4-N-Maleimidobenzoicacid-NHS
  • HY-174929
    DBCO-PEG3400-Amine

    DBCO-PEG3400-NH2

    		 Biochemical Assay Reagents Others
    DBCO-PEG3400-Amine (DBCO-PEG3400-NH2) is a polyethylene glycol derivative containing dibenzocyclooctyne. DBCO-PEG-Amine is a universal, modular "bridge molecule": it forms stable covalent linkage with target materials (e.g., MSN or polymers) via the amino group at one end, while the DBCO group at the other end enables efficient, specific, and biocompatible click chemical conjugation with any azide-bearing biological entities (e.g., bacteria, cells) in subsequent steps .
    DBCO-PEG3400-Amine
  • HY-P3223A
    Biphalin acetate

    		Opioid Receptor Neurological Disease
    Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin acetate
  • HY-P2266
    SAH-EZH2

    		Histone Methyltransferase Cancer
    SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27 .
    SAH-EZH2
  • HY-145823
    EGFR-IN-42

    		EGFR Cancer
    EGFR-IN-42 (Compound 17b) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-42 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-42 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-42 has superior anti-cancer activity .
    EGFR-IN-42
  • HY-145824
    EGFR-IN-43

    		EGFR Cancer
    EGFR-IN-43 (Compound 17c) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-43 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-43 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-43 has superior anti-cancer activity .
    EGFR-IN-43
  • HY-174935B
    DBCO-PEG3400-NHS

    		Biochemical Assay Reagents Others
    DBCO-PEG3400-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
    DBCO-PEG3400-NHS
  • HY-174935D
    DBCO-PEG10000-NHS

    		Biochemical Assay Reagents Others
    DBCO-PEG10000-NHS is a dibenzocyclooctyne-conjugated polyethylene glycol derivative bearing an NHS group. DBCO-PEG-NHS forms a stable covalent linkage with the amino group of target molecules via the NHS ester at one end, while introducing a DBCO group at the other end, thus preparing for subsequent click chemical conjugation with any azide-bearing molecule or material .
    DBCO-PEG10000-NHS
  • HY-P2203A
    SAHM1 TFA

    		Notch Cancer
    SAHM1 TFA is a Notch pathway inhibitor. SAHM1 TFA stabilizes hydrocarbon-stapled alpha helical peptide. SAHM1 TFA targets the protein-protein interface and prevents Notch complex assembly.
    SAHM1 TFA
  • HY-P10488
    cycFWRPW

    		Wnt Others Cancer
    cycFWRPW is a peptide inhibitor of TLE1. TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors, and inhibits Wnt signaling .
    cycFWRPW
  • HY-P10212
    AVLX-125

    UCCB01-125

    		 iGluR Neurological Disease
    AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with Kd value of 10 nM. AVLX-125 can be used in the study of inflammatory pain .
    AVLX-125
  • HY-P3223
    Biphalin TFA

    		Opioid Receptor Neurological Disease
    Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin TFA
  • HY-D2925
    dTCOBG

    dTCO-SNAP

    		 Biochemical Assay Reagents Others
    dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling .
    dTCOBG
  • HY-D3274
    PE-Cy5

    		Fluorescent Dye Others
    PE-Cy5 is a tandem fluorescent dye commonly used in flow cytometry, immunofluorescence, and cell biology research. It is formed by the covalent linkage of two fluorescent molecules, namely phycoerythrin and CY5. PE-Cy5 binds to human FcγRI (CD64), and this binding can be blocked by human pooled serum, anti-CD64 monoclonal antibodies targeting the ligand-binding region, or aggregated IgG. PE-Cy5 supports three-color flow cytometry analysis, and whole blood staining can partially reduce its non-specific binding (Ex/Em = 450-500 nm/665 nm) .
    PE-Cy5
  • HY-N17580
    Lyciumin D

    		Renin Cardiovascular Disease
    Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension .
    Lyciumin D
  • HY-125040
    Isariin C

    		Endogenous Metabolite Inflammation/Immunology
    Isariin C is a flavonoid glycoside with antioxidant activity. Isariin C activates angiogenesis. Isariin C exhibits insecticidal activity in certain insects .
    Isariin C
  • HY-W1126955
    Enlicitide (decanoate)

    MK-0616 (decanoate)

    		 PCSK9 Metabolic Disease Inflammation/Immunology
    Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease .
    Enlicitide (decanoate)
  • HY-P11837
    NECT-224

    		Biochemical Assay Reagents Cancer
    NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with 64Cu or 68Ga .
    NECT-224

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