2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-42

EGFR-IN-42 (Compound 17b) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-42 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-42 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-42 has superior anti-cancer activity.

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EGFR-IN-42 Chemical Structure

EGFR-IN-42 Chemical Structure

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EGFR-IN-42 Related Antibodies

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Description

EGFR-IN-42 (Compound 17b) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-42 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-42 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-42 has superior anti-cancer activity[1].

Molecular Weight

846.43

Formula

C49H53ClFN5O5
SMILES

ClC1=CC(NC2=C3C(C=C(OC)C(OCCCNC(CCCCCN(CCOC4=CC=C(C=C4)/C(C5=CC=C(C=C5)O)=C(CC)\C6=CC=CC=C6)C)=O)=C3)=NC=N2)=CC=C1F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-42 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-42EGFREpidermal growth factor receptorErbB-1HER1nanomolartamoxifenendoxifengefitinibcovalent linkageanti-cancerInhibitorinhibitorinhibit

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