2. Epigenetics
  3. Histone Methyltransferase
  4. SAH-EZH2

SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27.

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SAH-EZH2 Chemical Structure

SAH-EZH2 Chemical Structure

CAS No. : 1453222-26-8

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SAH-EZH2 Related Antibodies

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27[1].

In Vitro

The selectivity of SAH-EZH2 activity is highlighted by the lack of a SAH-EZH2 effect on the H3K4, H3K9 and H3K36 methyl marks. MLL-AF9 leukemia cells, which are dependent on PRC2, undergo growth arrest and monocyte-macrophage differentiation upon treatment with SAH-EZH2, consistent with observed changes in expression of PRC2-regulated, lineage-specific marker genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SAH-EZH2 Related Antibodies
Molecular Weight

3431.99

Formula

C155H256N48O40
CAS No.
Sequence Shortening

Ac-FSSNR-{(S)-2-(4ʹ-pentenyl)Ala}-KIL-{(S)-2-(4ʹ-pentenyl)Ala}-RTQILNQEWKQRRIQPV (Covalent bridge: Ala6-Ala10)
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SAH-EZH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAH-EZH21453222-26-8Histone Methyltransferaseanti-proliferativedifferentiationPRC2EZH2EEDInhibitorinhibitorinhibit

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