2. GPCR/G Protein
  3. CRFR
  4. Stressin I

Stressin I  (Synonyms: Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41))

Cat. No.: HY-P1368
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Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Stressin I Chemical Structure

Stressin I Chemical Structure

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Stressin I Related Antibodies

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Description

Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) is a potent CRF1 receptor-selective agonist with a Ki of 1.7 nM. Stressin I induces increases in adrenocorticotropic hormone (ACTH) levels in rats[1].

IC50 & Target

Ki: 1.7 nM (CRF1), 222 nM (CRF2)[1]
Molecular Weight

4472.20

Formula

C203H337N57O56
Sequence

Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-{d-Phe}-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Glu-His-Ser-Lys-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 (Covalent bond: Glu28-Lys31)
Sequence Shortening

Ac-PPISLDLT-{d-Phe}-HLLREVLE-{Nle}-ARAEQLAQQEHSKRKLXEII-NH2 (Covalent bond: Glu28-Lys31)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Stressin I Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stressin ICyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)CRFRCorticotropin-releasing Factor ReceptorCRHRadrenal-intact male ratpellet outputInhibitorinhibitorinhibit

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