Search Result

Results for "

cysteine (Cys)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (21) Antibiotic (1) AUTACs (1) Autophagy (1) Bacterial (1) Beta-lactamase (1) Biochemical Assay Reagents (8) Connective Peptide (1) Cytochrome P450 (1) DNA/RNA Synthesis (3) Drug Derivative (9) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) EGFR (1) Endogenous Metabolite (3) Exosomes (1) Fluorescent Dye (3) Fungal (1) GSK-3 (1) HIV (5) Influenza Virus (1) Insecticide (1) Integrin (3) Isotope-Labeled Compounds (3) MARCKS (1) MHC (1) NF-κB (2) p97 (1) PKA (1) PKC (1) Reactive Oxygen Species (ROS) (2) TGF-beta/Smad (1) Toll-like Receptor (TLR) (2) Virus Protease (1) β-glucuronidase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Infection (7) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (5)

By Targets:

Amino Acid Derivatives (21)

Antibiotic (1)

AUTACs (1)

Autophagy (1)

Bacterial (1)

Beta-lactamase (1)

Biochemical Assay Reagents (8)

Connective Peptide (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (3)

Drug Derivative (9)

Drug Metabolite (1)

Drug-Linker Conjugates for ADC (1)

EGFR (1)

Endogenous Metabolite (3)

Exosomes (1)

Fluorescent Dye (3)

Fungal (1)

GSK-3 (1)

HIV (5)

Influenza Virus (1)

Insecticide (1)

Integrin (3)

Isotope-Labeled Compounds (3)

MARCKS (1)

MHC (1)

NF-κB (2)

p97 (1)

PKA (1)

PKC (1)

Reactive Oxygen Species (ROS) (2)

TGF-beta/Smad (1)

Toll-like Receptor (TLR) (2)

Virus Protease (1)

β-glucuronidase (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (3)

Infection (7)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: ASCT Calpain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W007798

Fmoc-Cys(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(Trt)-OH is a cysteine derivative .

HY-P1351

Angiopep-2-Cys	Biochemical Assay Reagents	Cancer
Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-113110

Cysteinylglycine L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cardiovascular Disease Cancer
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions .

HY-W013143

Fmoc-Cys(Acm)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(Acm)-OH is a cysteine derivative .

HY-P4093

Cys-Penetratin	Biochemical Assay Reagents	Others
Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery .

HY-176415

Cys-MC-GGFG-Dxd	Drug-Linker Conjugates for ADC	Cancer
Cys-MC-GGFG-Dxd is a cysteine-modified, cleavable ADC drug-linker conjugate. Cys-MC-GGFG-Dxd consists of a maleimidocaproyl-glycine-glycine-L-phenylalanine-glycine (MC-GGFG) linker and an Exatecan (HY-13631) derivative (DXd) (HY-13631D) payload. Cys-MC-GGFG-Dxd can be further conjugated to anti-HER2 IgG1κ antibody for the synthesis of antibody-drug conjugates (ADC), such as the breast cancer-targeting ADC compound Fam-trastuzumab deruxtecan-nxki (Enhertu) .

HY-165613

Pam2Cys Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine	Toll-like Receptor (TLR) Influenza Virus NF-κB	Infection Inflammation/Immunology
Pam2Cys (Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis(palmitoyloxy)propyl]cysteine) is a TLR2 agonist and immunostimulant. Pam2Cys binds to TLR2 to activate dendritic cells and trigger the TLR2-dependent NF-κB signaling pathway. Pam2Cys also induces dendritic cell maturation by upregulating the expression of cell surface MHC II molecules. Pam2Cys activates innate immune signaling pathways, drives pro-inflammatory and antimicrobial responses, enhances the expression of macrophage activation markers, increases phagocytic activity, induces the release of IL-12 and pro-inflammatory cytokines, and polarizes macrophages into a pro-inflammatory, antimicrobial phenotype without interfering with IL-10-induced macrophage polarization. Pam2Cys also serves as the lipid moiety in synthetic lipopeptide vaccines and possesses self-adjuvant properties. Pam2Cys enhances the immunogenicity of conjugated peptide segments and induces cellular and humoral immune responses. However, it does not activate CD4 T cells in mouse splenocyte cultures when used alone. Pam2Cys activates pulmonary TLR2 signaling pathways, triggers innate immune responses, recruits neutrophils and macrophages, induces the secretion of various cytokines, alleviates symptoms and damages associated with influenza A virus infection in mice without impairing adaptive immunity. Pam2Cys can be used in studies related to tuberculosis and influenza A virus infection .

HY-P11308

Cys-GE11	EGFR	Cancer
Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine (Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity .

HY-D2186

BTD probe-1 1 Publications Verification	Biochemical Assay Reagents	Others
BTD probe-1 is a benzothiazine-based chemoproteomic probe and selective protein S-sulfenic acid (Cys-SOH) labeling agent. BTD probe-1 labels protein S-sulfenic acids in vitro in cell and tissue samples, and in situ in intact cells, enabling detection or enrichment of modified proteins/peptides. BTD probe-1 exhibits no cytotoxicity in cells at concentrations ≤1 mM. BTD probe-1 enables global, site-specific mapping and quantification of cysteine S-sulfenylation in complex proteomes with lower input material .

HY-W010724

Fmoc-D-Cys(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-D-Cys(Trt)-OH is a cysteine derivative .

HY-139093A

Paracetamol-cysteine TFA 1 Publications Verification APAP-Cys TFA	Drug Derivative	Others
Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .

HY-114788

Lysylcysteine L-Lysyl-L-cysteine; Lys-Cys; H-Lys-Cys-OH	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.

HY-W101367

Ac-Cys(Bzl)-OH N-Acetyl-S-benzyl-L-cysteine; Benzylmercapturic acid	Drug Metabolite	Others
Ac-Cys(Bzl)-OH (N-Acetyl-S-benzyl-L-cysteine) is a toluene metabolite. Ac-Cys(Bzl)-OH in urine samples is a good marker of occupational toluene exposure.

HY-W012075

H-Cys(pMeOBzl)-OH	Amino Acid Derivatives	Others
H-Cys(pMeOBzl)-OH is a cysteine derivative .

HY-134852

Fmoc-Cys(STmp)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(STmp)-OH is a cysteine derivative .

HY-W069127F

Biotin-benzoboroxole Bio-ben	Biochemical Assay Reagents	Others
Biotin-benzoboroxole (Bio-ben) is a functional probe for the detection of cysteine sulfenic acid (Cys-SOH) .

HY-D2315

Probe-Cys	Fluorescent Dye	Cancer
Probe-Cys is a water-soluble and selective near-infrared fluorescent probe for Cysteine (Cys) (λex= 680 nm, λem=710 nm) that is not interfered by Hcy, GSH, and HS-. Probe-Cys can react with the stimulant DTT (HY-15917) and the NEM (HY-D0843) in HepG2 cells and zebrafish for the detection of endogenous Cys. Probe-Cys can also be used for imaging Cys in Arabidopsis thaliana. Probe-Cys provides a method for cancer diagnosis and exploration of plant sulfur metabolism .

HY-P1801A

Cys-TAT(47-57) TFA Cys-[HIV-Tat (47-57)] TFA	HIV Drug Derivative	Others
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) TFA, TAT (HY-P0281) derivative, is a Cysteine (HY-Y0337)-tagged cell-penetrating peptide (CPP) derived from the HIV TAT protein. Cys-TAT(47-57) TFA can be used for the research for the research of drug delivery .

HY-P4087

Cys(Npys)-(Arg)9	HIV	Infection Cancer
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-W736950A

H-L-Cys(MDNPE)-OH hydrochloride	Amino Acid Derivatives	Others
H-L-Cys(MDNPE)-OH hydrochloride is a cysteine derivative with a short peptide sequence attached to the thiol group of cysteine.

HY-W041857

Boc-Cys(tBu)-OH	Amino Acid Derivatives	Others
Boc-Cys(tBu)-OH is a cysteine derivative .

HY-W053550

H-D-Cys(Trt)-OH	Amino Acid Derivatives	Others
H-D-Cys(Trt)-OH is a cysteine derivative .

HY-P5969

Cys-V5 Peptide	Biochemical Assay Reagents	Others
Cys-V5 Peptide, a tag peptide, is the V5 Peptide with an N-terminal cysteine. Cys-V5 Peptide can be used to label proteins

HY-114788A

Lysylcysteine TFA L-Lysyl-L-cysteine TFA; Lys-Cys TFA; H-Lys-Cys-OH TFA	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) TFA is a dipeptide composed of lysine and cysteine .

HY-162675

COB-187	GSK-3	Infection Neurological Disease Metabolic Disease Cancer
COB-187 is a potent, ATP-competitive and selective inhibitor of GSK-3β. COB-187 inhibits GSK-3 through a reversible and Cysteine (Cys)-199-dependent mechanism. COB-187 inhibits LPS induced cytokine production and SARS-CoV-2 spike protein-induced CXCL10 production .

HY-160902

2G-HaloAUTAC	Autophagy AUTACs	Others
2G-HaloAUTAC (Compound tt44) is a Autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine (L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an Autophagic mechanism .

HY-139093

Paracetamol-cysteine APAP-Cys	Drug Derivative	Others
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

HY-W141779

Boc-Cys(Npys)-OH	Amino Acid Derivatives	Others
Boc-Cys(Npys)-OH is a cysteine derivative .

HY-159703

Glu-Cys Glutamyl-cysteine; PSSGlu-Cys	Endogenous Metabolite	Others
Glu-Cys (Glutamyl-cysteine; PSSGlu-Cys) is a dipeptide composed of L-glutamic acid (HY-14608) and L-cysteine (HY-Y0337) joined by a peptide linkage .

HY-W007798S

Fmoc-Cys(Trt)-OH-1,2,3-13C3,15N	Isotope-Labeled Compounds	Others
Fmoc-Cys(Trt)-OH-1,2,3- ¹³C₃, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Cys(Trt)-OH-1,2,3 (HY-W007798). Fmoc-Cys(Trt)-OH is a cysteine derivative .

HY-P1801

Cys-TAT(47-57) Cys-[HIV-Tat (47-57)]	HIV Drug Derivative	Others
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]), TAT (HY-P0281) derivative, is a Cysteine (HY-Y0337)-tagged cell-penetrating peptide (CPP) derived from the HIV TAT protein. Cys-TAT(47-57) can be used for the research for the research of drug delivery .

HY-P4101

Cys(Npys)-TAT (47-57)	HIV	Infection
Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .

HY-P4087B

Cys(Npys)-(Arg)9 acetate	HIV	Others
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-115754

S-(N-PhenethylthiocarbaMoyl)-L-cysteine PEITC-Cys	DNA/RNA Synthesis Cytochrome P450	Cancer
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells . S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .

HY-113110A

Cysteinylglycine TFA L-Cysteinylglycine TFA; Cys-Gly TFA; H-Cys-Gly-OH TFA	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cardiovascular Disease Cancer
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) TFA is a dipeptide formed by the peptide bond connection of cysteine and glycine. Cysteinylglycine TFA is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine TFA can reduce trivalent iron to divalent iron, driving the redox cycle of iron, generating reactive oxygen species (ROS), stimulating oxidative reactions, inducing lipid peroxidation in human plasma LDL lipoproteins, and causing oxidative damage to DNA base. Cysteinylglycine TFA can be used as a biomarker to assess ischemic heart disease and breast cancer, etc ^[1][2][3][4].

HY-W010835

Boc-D-Cys(Trt)-OH Boc-S-trityl-D-cysteine	Amino Acid Derivatives	Others
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .

HY-W013651

H-DL-Cys.HCl	Amino Acid Derivatives	Others
H-DL-Cys.HCl is a cysteine derivative .

HY-148667

H-Cys(Acm)-OH	Biochemical Assay Reagents	Others
H-Cys(Acm)-OH is a cysteine .

HY-W011773

H-Cys(Bzl)-OMe.HCl	Amino Acid Derivatives	Others
H-Cys(Bzl)-OMe.HCl is a cysteine derivative .

HY-W013118

Fmoc-Cys(pMeOBzl)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(pMeOBzl)-OH is a cysteine derivative .

HY-W014329

H-Cys(Bzl)-OH	Amino Acid Derivatives	Others
H-Cys(Bzl)-OH is a cysteine derivative .

HY-W671129

Frenolicin B	Antibiotic Fungal	Infection
Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC₅₀ of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits Peroxiredoxin 1 via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria .

HY-W007798S1

Fmoc-Cys(Trt)-OH-d2	Isotope-Labeled Compounds	Others
Fmoc-Cys(Trt)-OH-d₂ is the deuterium labeled Fmoc-Cys(Trt)-OH. Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative .

HY-W010775

(Z-Cys-OH)2	Amino Acid Derivatives	Others
(Z-Cys-OH)2 is a cysteine derivative .

HY-P11541

CTP-Cys	Amino Acid Derivatives	Others
CTP-Cys is a cysteine attached to CTP (HY-P4094) for peptide conjugation .

HY-P11421

Cys-His Tag	Biochemical Assay Reagents	Others
Cys-His Tag is a dual-purpose protein tag combining a cysteine residue and a Histidine tag. Cys-His Tag can be used to improve marker specificity or introduce covalent binding sites .

HY-P4022

Mca-Glu-Asp-Ala-Ser-Thr-Pro-Cys-OH	Drug Derivative	Others
Mca-Glu-Asp-Ala-Ser-Thr-Pro-Cys-OH is a L-Cysteine (HY-Y0337) derivative .

HY-111945

Cys modifier 1	Fluorescent Dye	Others
Cys modifier 1 (compound 7) is a cysteine-selective protein modifier for protein bioconjugation. A fluorescent carbonylacrylic derivative bearing nitrobenzofurazan (λ_ex=465nm and λ_em539 nm)_[1].

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-160255A

N-Cbz-D-Cysteine Cbz-D-Cys	Beta-lactamase	Infection
N-Cbz-D-Cysteine (Cbz-D-Cys) (compound 5) is a potent β-lactamase II inhibitor with a K_i value of 20.1 µM .

Cat. No.	Product Name

HY-L945

Sulfonyl Fluoride Fragment Library

1162 compounds

Sulfonyl fluoride (-SO₂F) overcomes the bottleneck of target selectivity in traditional covalent warheads through its unique chemical and biological properties, which rely heavily on cysteine (Cys) residues. Featuring high stability and tunable electrophilicity under physiological conditions, it can target a wide range of nucleophilic residues including lysine (Lys), tyrosine (Tyr), serine (Ser), and histidine (His). It offers the advantages of a broader druggable space, lower off-target risks, and long-lasting efficacy, with numerous reported cases in the research of covalent inhibitors, Molecular glue, PROTACs, and chemical biology probe development.

MCE constructs a highly diverse sulfonyl fluoride fragment library based on the reactivity, stability and physiological compatibility of sulfonyl fluoride. The library contains 1000 efficiently synthesized and stable sulfonyl fluoride fragments, which ensure precise reactivity of the warhead and retain sufficient derivatization space for subsequent optimization. Combined with the modular strategy of SuFEx click chemistry, it enables versatile modification of compounds and functionalization of complex molecules, improves the efficiency of structural optimization and rapidly expands druggability, making it suitable for high-throughput probe and custom covalent library construction. It provides an efficient research tool for the development of broad-spectrum covalent inhibitors targeting Lys/Tyr/Ser/His, covalent PROTACs for E3 ligases and chemical biology probe development, meeting the requirements of modern drug research for high throughput, high success rate and high derivatization potential.

This library contains 1,162 sulfonyl fluoride fragments with high structural diversity, favorable drug-like properties and tunable electrophilicity. It is well suited for precise targeting of non-Cys residues and meets the criteria of simple structure and high derivatization potential. It effectively improves

HY-LD004

DEL Covalent Library

14 million compounds

DEL technology enables the simultaneous screening of millions or billions of compounds in a single tube by covalently linking each small molecule with a unique DNA sequence. Traditional DEL screening primarily focuses on identifying non-covalent binding molecules, where interactions with the target are reversible. In contrast, DNA‑encoded covalent library is an ultra‑high‑throughput screening library developed on the basis of conventional DNA‑encoded library technology. It incorporates controllable electrophilic covalent warheads capable of forming irreversible covalent bonds with amino acid residues at the active sites of target proteins, including Cys, Lys, Ser, Tyr, and others. This covalent binding enhances binding affinity, prolongs residence time at the target site, and has the potential to overcome challenges associated with traditional non-covalent inhibitors, such as drug resistance or off-target effects.

Each compound in the library contains both a binding domain and an electrophilic warhead. It first recognizes and binds to the target through non covalent interactions, and then forms a stable covalent bond with key amino acid residues to achieve irreversible inhibition. This library is specifically designed for the discovery of potent, long lasting, and highly selective covalent inhibitors, particularly for undruggable targets such as kinases, GPCRs, proteases, and mutant oncoproteins. Each molecule is uniquely labeled with a DNA barcode for molecular identification and sequencing decoding.

This library is an advanced and highly diverse collection, consists of 35 independent sub-libraries with a total scaleof 14 million compounds, It incorporates over 14 experimentally validated covalent warheads capable of targeting cysteine, lysine, arginine, aspartic acid and glutamic acid. This library is constructed with diverse drug like core scaffolds and integrated controllable covalent warheads, it features structural diversity, reaction spec

Cat. No.	Product Name	Type

HY-D2186

BTD probe-1

1 Publications Verification

Fluorescent Dyes

BTD probe-1 is a benzothiazine-based chemoproteomic probe and selective protein S-sulfenic acid (Cys-SOH) labeling agent. BTD probe-1 labels protein S-sulfenic acids in vitro in cell and tissue samples, and in situ in intact cells, enabling detection or enrichment of modified proteins/peptides. BTD probe-1 exhibits no cytotoxicity in cells at concentrations ≤1 mM. BTD probe-1 enables global, site-specific mapping and quantification of cysteine S-sulfenylation in complex proteomes with lower input material .

HY-D2315

Probe-Cys

Fluorescent Dyes

Probe-Cys is a water-soluble and selective near-infrared fluorescent probe for Cysteine (Cys) (λex= 680 nm, λem=710 nm) that is not interfered by Hcy, GSH, and HS-. Probe-Cys can react with the stimulant DTT (HY-15917) and the NEM (HY-D0843) in HepG2 cells and zebrafish for the detection of endogenous Cys. Probe-Cys can also be used for imaging Cys in Arabidopsis thaliana. Probe-Cys provides a method for cancer diagnosis and exploration of plant sulfur metabolism .

Cat. No.	Product Name	Target	Research Area

HY-W007798

Fmoc-Cys(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(Trt)-OH is a cysteine derivative .

HY-P1351

Angiopep-2-Cys	Biochemical Assay Reagents	Cancer
Angiopep-2-cys is a conjugate of Angiopep-2 hydrochloride (HY-P2341) and cysteine. Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer .

HY-113110

Cysteinylglycine L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cardiovascular Disease Cancer
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions .

HY-W013143

Fmoc-Cys(Acm)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(Acm)-OH is a cysteine derivative .

HY-P4093

Cys-Penetratin	Biochemical Assay Reagents	Others
Cys-Penetratin is a cysteine-containing cell-penetrating peptide with sequence CRQIKIWFQNRRMKWKK. Cys-Penetratin can Cys-Penetratin can be used for the research for the research of drug delivery .

HY-P11308

Cys-GE11	EGFR	Cancer
Cys-GE11 is an N-terminal modified GE11 (HY-P10128) with cysteine (Cys) added. Cys-GE11 can be coupled through the thiol group of Cys. Cys-GE11 can be linked to PEG-P (TMC-DTC) through the N-terminus of cysteine to form a targeted polymer. Cys-GE11 can target cells with high EGFR expression (such as SMMC-7721 cells). Cys-GE11 can significantly enhance drug enrichment at the tumor site and exhibit low toxicity .

HY-W010724

Fmoc-D-Cys(Trt)-OH	Amino Acid Derivatives	Others
Fmoc-D-Cys(Trt)-OH is a cysteine derivative .

HY-114788

Lysylcysteine L-Lysyl-L-cysteine; Lys-Cys; H-Lys-Cys-OH	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.

HY-W012075

H-Cys(pMeOBzl)-OH	Amino Acid Derivatives	Others
H-Cys(pMeOBzl)-OH is a cysteine derivative .

HY-134852

Fmoc-Cys(STmp)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(STmp)-OH is a cysteine derivative .

HY-P1801A

Cys-TAT(47-57) TFA Cys-[HIV-Tat (47-57)] TFA	HIV Drug Derivative	Others
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) TFA, TAT (HY-P0281) derivative, is a Cysteine (HY-Y0337)-tagged cell-penetrating peptide (CPP) derived from the HIV TAT protein. Cys-TAT(47-57) TFA can be used for the research for the research of drug delivery .

HY-P4087

Cys(Npys)-(Arg)9	HIV	Infection Cancer
Cys(Npys)-(Arg)9 is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-W041857

Boc-Cys(tBu)-OH	Amino Acid Derivatives	Others
Boc-Cys(tBu)-OH is a cysteine derivative .

HY-W053550

H-D-Cys(Trt)-OH	Amino Acid Derivatives	Others
H-D-Cys(Trt)-OH is a cysteine derivative .

HY-P5969

Cys-V5 Peptide	Biochemical Assay Reagents	Others
Cys-V5 Peptide, a tag peptide, is the V5 Peptide with an N-terminal cysteine. Cys-V5 Peptide can be used to label proteins

HY-114788A

Lysylcysteine TFA L-Lysyl-L-cysteine TFA; Lys-Cys TFA; H-Lys-Cys-OH TFA	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) TFA is a dipeptide composed of lysine and cysteine .

HY-139093

Paracetamol-cysteine APAP-Cys	Drug Derivative	Others
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

HY-W141779

Boc-Cys(Npys)-OH	Amino Acid Derivatives	Others
Boc-Cys(Npys)-OH is a cysteine derivative .

HY-159703

Glu-Cys Glutamyl-cysteine; PSSGlu-Cys	Endogenous Metabolite	Others
Glu-Cys (Glutamyl-cysteine; PSSGlu-Cys) is a dipeptide composed of L-glutamic acid (HY-14608) and L-cysteine (HY-Y0337) joined by a peptide linkage .

HY-P1801

Cys-TAT(47-57) Cys-[HIV-Tat (47-57)]	HIV Drug Derivative	Others
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]), TAT (HY-P0281) derivative, is a Cysteine (HY-Y0337)-tagged cell-penetrating peptide (CPP) derived from the HIV TAT protein. Cys-TAT(47-57) can be used for the research for the research of drug delivery .

HY-P4101

Cys(Npys)-TAT (47-57)	HIV	Infection
Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .

HY-P4087B

Cys(Npys)-(Arg)9 acetate	HIV	Others
Cys(Npys)-(Arg)9 acetate is a synthetic cationic cell-penetrating peptide with a reversible thiol-reactive nitropyridyl (Npys) group. Cys(Npys)-(Arg)9 acetate efficiently mediates the internalization and delivery of various "cargo" such as proteins and antibodies by forming reversible disulfide bonds with surface-exposed cysteine residues. Cys(Npys)-(Arg)9 acetate endows TALEN proteins with cell-penetrating activity, enabling gene knockout in mammalian cells and protein transduction in wheat microspores. Cys(Npys)-(Arg)9 acetate can be conjugated with antibodies to form cationized IgG for enhancing endosomal escape of oligonucleotides, or form siRNA delivery complexes. When the molar ratio of Cys(Npys)-(Arg)9 acetate to loaded molecules is higher than 1:1, it exerts certain cytotoxic effects on cells. Cys(Npys)-(Arg)9 acetate can be used in studies related to oral squamous cell carcinoma and HIV infection .

HY-113110A

Cysteinylglycine TFA L-Cysteinylglycine TFA; Cys-Gly TFA; H-Cys-Gly-OH TFA	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cardiovascular Disease Cancer
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) TFA is a dipeptide formed by the peptide bond connection of cysteine and glycine. Cysteinylglycine TFA is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine TFA can reduce trivalent iron to divalent iron, driving the redox cycle of iron, generating reactive oxygen species (ROS), stimulating oxidative reactions, inducing lipid peroxidation in human plasma LDL lipoproteins, and causing oxidative damage to DNA base. Cysteinylglycine TFA can be used as a biomarker to assess ischemic heart disease and breast cancer, etc ^[1][2][3][4].

HY-W010835

Boc-D-Cys(Trt)-OH Boc-S-trityl-D-cysteine	Amino Acid Derivatives	Others
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .

HY-W013651

H-DL-Cys.HCl	Amino Acid Derivatives	Others
H-DL-Cys.HCl is a cysteine derivative .

HY-W011773

H-Cys(Bzl)-OMe.HCl	Amino Acid Derivatives	Others
H-Cys(Bzl)-OMe.HCl is a cysteine derivative .

HY-W013118

Fmoc-Cys(pMeOBzl)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(pMeOBzl)-OH is a cysteine derivative .

HY-W014329

H-Cys(Bzl)-OH	Amino Acid Derivatives	Others
H-Cys(Bzl)-OH is a cysteine derivative .

HY-W010775

(Z-Cys-OH)2	Amino Acid Derivatives	Others
(Z-Cys-OH)2 is a cysteine derivative .

HY-P11414

Cys-flag peptide	Peptides	Neurological Disease
Cys-flag peptide (CDYKDDDDK) is a FLAG tag peptide containing cysteine. Cys-flag peptide has a targeted interaction for protein purification and detection. Cys-flag peptide can be used for the research of neurological disease, such as Alzheimer’s disease .

HY-P11541

CTP-Cys	Amino Acid Derivatives	Others
CTP-Cys is a cysteine attached to CTP (HY-P4094) for peptide conjugation .

HY-P5300A

YNPCVMYL (Thioester: Cys4-Leu8) TFA	Peptides	Others
YNPCVMYL (Thioester: Cys4-Leu8) TFA is a polypeptide chain of the YNPCVMYL sequence. The link between the fourth and eighth amino acids in the sequence has the properties of a thioester, which is formed between cysteine (Cys4) and leucine (Leu8).

HY-P11421

Cys-His Tag	Biochemical Assay Reagents	Others
Cys-His Tag is a dual-purpose protein tag combining a cysteine residue and a Histidine tag. Cys-His Tag can be used to improve marker specificity or introduce covalent binding sites .

HY-P4022

Mca-Glu-Asp-Ala-Ser-Thr-Pro-Cys-OH	Drug Derivative	Others
Mca-Glu-Asp-Ala-Ser-Thr-Pro-Cys-OH is a L-Cysteine (HY-Y0337) derivative .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-W041997

H-Cys(Z)-OH	Amino Acid Derivatives	Others
H-Cys(Z)-OH is a cysteine derivative .

HY-W050803

H-D-Cys(Bzl)-OH	Amino Acid Derivatives	Others
H-D-Cys(Bzl)-OH is a cysteine derivative .

HY-W010871

Fmoc-Cys(4-MeBzl)-OH	Amino Acid Derivatives	Others
Fmoc-Cys(4-MeBzl)-OH is a cysteine derivative .

HY-P3920

Cys-Kemptide	PKA	Cancer
Cys-Kemptide is a cysteine-terminated substrate peptide that can used to measure protein kinase A (PKA) activity .

HY-P6009

Cys-αvβ6-BP	Integrin	Cancer
Cys-αvβ6-BP is a cysteine-terminated αvβ6 binding peptide .

HY-P6009A

Cys-αvβ6-BP TFA	Integrin	Cancer
Cys-αvβ6-BP TFA is a cysteine-terminated αvβ6 binding peptide .

HY-P4316

Cys(NPys)-D{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg}-NH2	Peptides	Others
Cys(NPys)-D{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg}-NH2 is a cell-penetrating polypeptide composed of nine arginines and cysteines, used to carry therapeutic agent into the cell .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-13443C

Exendin-4-Cys	Drug Derivative	Metabolic Disease
Exendin-4-Cys is a Cysteine-modified Exendin-4 (HY-13443). Exendin-4-Cys is coupled with LMWC-PDP. Exendin-4-Cys can be used in the research of type 2 diabetes .

HY-P1876D

Cys-NLS	Peptides	Others
Cys-NLS is a cysteine-containing nuclear localization signal peptide derived from the simian virus 40 large T antigen, which enhances nuclear import. Cys-NLS can undergo a coupling reaction through the common backbone of Cys .

HY-P5300

YNPCVMYL (Thioester: Cys4-Leu8)	Peptides	Others
YNPCVMYL (Thioester: Cys4-Leu8) is a polypeptide chain of the YNPCVMYL sequence. The link between the fourth and eighth amino acids in the sequence has the properties of a thioester, which is formed between cysteine (Cys4) and leucine (Leu8).

HY-P0307B

Penetratin-Cys	Biochemical Assay Reagents	Neurological Disease
Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders .

HY-P1654A

A20FMDV2-Cys	Integrin	Cancer
A20FMDV2-Cys is a cysteine-containing 20-mer peptide that targets integrin αvβ6 with high affinity. A20FMDV2-Cys can be used for targeted liposome modification to enhance liver and bile duct targeting. A20FMDV2-Cys is applicable for research in drug delivery .

HY-P11781A

Cys-HW12	Drug Derivative	Cancer
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .

HY-P3436B

Cys-PCM	Connective Peptide	Cardiovascular Disease
Cys-PCM is a cardiomyocyte-targeting peptide (PCM) derived from WLSEAGPVVTVRALRGTGSW (HY-P3436) with a cysteine at the N-terminus for conjugation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113110

Cysteinylglycine L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH	Natural Products Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions .

HY-113110A

Cysteinylglycine TFA L-Cysteinylglycine TFA; Cys-Gly TFA; H-Cys-Gly-OH TFA	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) TFA is a dipeptide formed by the peptide bond connection of cysteine and glycine. Cysteinylglycine TFA is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine TFA can reduce trivalent iron to divalent iron, driving the redox cycle of iron, generating reactive oxygen species (ROS), stimulating oxidative reactions, inducing lipid peroxidation in human plasma LDL lipoproteins, and causing oxidative damage to DNA base. Cysteinylglycine TFA can be used as a biomarker to assess ischemic heart disease and breast cancer, etc ^[1][2][3][4].

HY-W671129

Frenolicin B	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC₅₀ of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits Peroxiredoxin 1 via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria .

Cat. No.	Product Name	Chemical Structure

HY-W007798S

Fmoc-Cys(Trt)-OH-1,2,3-13C3,15N
Fmoc-Cys(Trt)-OH-1,2,3- ¹³C₃, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Cys(Trt)-OH-1,2,3 (HY-W007798). Fmoc-Cys(Trt)-OH is a cysteine derivative .

HY-W007798S1

Fmoc-Cys(Trt)-OH-d2
Fmoc-Cys(Trt)-OH-d₂ is the deuterium labeled Fmoc-Cys(Trt)-OH. Fmoc-Cys(Trt)-OH is an N-terminal protected cysteine derivative .

HY-146659S

S-Phenyl-DL-cysteine-d2
S-Phenyl-DL-cysteine-3,3-d₂ is the deuterium labeled S-Phenyl-DL-cysteine-3,3 .

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